Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2020

31-01-2020 | Original Paper

Autism Spectrum Disorder Symptoms are Associated with Connectivity Between Large-Scale Neural Networks and Brain Regions Involved in Social Processing

Auteurs: Korey P. Wylie, Jason R. Tregellas, Joshua J. Bear, Kristina T. Legget

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The neurobiology of autism spectrum disorder remains poorly understood. The present study addresses this knowledge gap by examining the relationship between functional brain connectivity and Autism Diagnostic Observation Schedule (ADOS) scores using publicly available data from the Autism Brain Imaging Data Exchange (ABIDE) database (N = 107). This relationship was tested across all brain voxels, without a priori assumptions, using a novel statistical approach. ADOS scores were primarily associated with decreased connectivity to right temporoparietal junction, right anterior insula, and left fusiform gyrus (p < 0.05, corrected). Seven large-scale brain networks influenced these associations. Findings largely encompassed brain regions involved in processing socially relevant information, highlighting the importance of these processes in autism spectrum disorder.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Pub. CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Pub. CrossRef
go back to reference Baron-Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). Another advanced test of theory of mind: Evidence from very high functioning adults with autism or asperger syndrome. Journal of Child Psychology and Psychiatry, 38(7), 813–822. CrossRef Baron-Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). Another advanced test of theory of mind: Evidence from very high functioning adults with autism or asperger syndrome. Journal of Child Psychology and Psychiatry, 38(7), 813–822. CrossRef
go back to reference Bell, A. J., & Sejnowski, T. J. (1995). An information-maximization approach to blind separation and blind deconvolution. Neural Computation, 7(6), 1129–1159. CrossRef Bell, A. J., & Sejnowski, T. J. (1995). An information-maximization approach to blind separation and blind deconvolution. Neural Computation, 7(6), 1129–1159. CrossRef
go back to reference Björnsdotter, M., Wang, N., Pelphrey, K., & Kaiser, M. D. (2016). Evaluation of quantified social perception circuit activity as a neurobiological marker of autism spectrum disorder. JAMA Psychiatry, 73(6), 614–621. CrossRef Björnsdotter, M., Wang, N., Pelphrey, K., & Kaiser, M. D. (2016). Evaluation of quantified social perception circuit activity as a neurobiological marker of autism spectrum disorder. JAMA Psychiatry, 73(6), 614–621. CrossRef
go back to reference Chen, H., Duan, X., Liu, F., Lu, F., Ma, X., Zhang, Y., et al. (2016). Multivariate classification of autism spectrum disorder using frequency-specific resting-state functional connectivity—A multi-center study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 64, 1–9. CrossRef Chen, H., Duan, X., Liu, F., Lu, F., Ma, X., Zhang, Y., et al. (2016). Multivariate classification of autism spectrum disorder using frequency-specific resting-state functional connectivity—A multi-center study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 64, 1–9. CrossRef
go back to reference Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433. CrossRef Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433. CrossRef
go back to reference Keehn, B., Shih, P., Brenner, L. A., Townsend, J., & Müller, R. A. (2013). Functional connectivity for an “island of sparing” in autism spectrum disorder: An fMRI study of visual search. Human brain mapping, 34(10), 2524–2537. CrossRef Keehn, B., Shih, P., Brenner, L. A., Townsend, J., & Müller, R. A. (2013). Functional connectivity for an “island of sparing” in autism spectrum disorder: An fMRI study of visual search. Human brain mapping, 34(10), 2524–2537. CrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. CrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. CrossRef
go back to reference Nair, A., Treiber, J. M., Shukla, D. K., Shih, P., & Müller, R.-A. (2013). Impaired thalamocortical connectivity in autism spectrum disorder: A study of functional and anatomical connectivity. Brain, 136(6), 1942–1955. CrossRef Nair, A., Treiber, J. M., Shukla, D. K., Shih, P., & Müller, R.-A. (2013). Impaired thalamocortical connectivity in autism spectrum disorder: A study of functional and anatomical connectivity. Brain, 136(6), 1942–1955. CrossRef
go back to reference Newman, M. (2010). Networks: An introduction. New York: Oxford University Press. CrossRef Newman, M. (2010). Networks: An introduction. New York: Oxford University Press. CrossRef
go back to reference Nichols, T. E., & Holmes, A. P. (2002). Nonparametric permutation tests for functional neuroimaging: A primer with examples. Human Brain Mapping, 15(1), 1–25. CrossRef Nichols, T. E., & Holmes, A. P. (2002). Nonparametric permutation tests for functional neuroimaging: A primer with examples. Human Brain Mapping, 15(1), 1–25. CrossRef
go back to reference Poustka, L., Jennen-Steinmetz, C., Henze, R., Vomstein, K., Haffner, J., & Sieltjes, B. (2012). Fronto-temporal disconnectivity and symptom severity in children with autism spectrum disorder. The World Journal of Biological Psychiatry, 13(4), 269–280. CrossRef Poustka, L., Jennen-Steinmetz, C., Henze, R., Vomstein, K., Haffner, J., & Sieltjes, B. (2012). Fronto-temporal disconnectivity and symptom severity in children with autism spectrum disorder. The World Journal of Biological Psychiatry, 13(4), 269–280. CrossRef
go back to reference Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services. Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services.
go back to reference Simon, N., & Tibshirani, R. (2014). Comment on" Detecting novel associations in large data sets" by Reshef Et Al, Science Dec 16, 2011. arXiv preprint arXiv:1401.7645. Simon, N., & Tibshirani, R. (2014). Comment on" Detecting novel associations in large data sets" by Reshef Et Al, Science Dec 16, 2011. arXiv preprint arXiv:1401.7645.
go back to reference Székely, G. J., Rizzo, M. L., & Bakirov, N. K. (2007). Measuring and testing dependence by correlation of distances. The Annals of Statistics, 35(6), 2769–2794. CrossRef Székely, G. J., Rizzo, M. L., & Bakirov, N. K. (2007). Measuring and testing dependence by correlation of distances. The Annals of Statistics, 35(6), 2769–2794. CrossRef
go back to reference Van Essen, D. C., Drury, H. A., Dickson, J., Harwell, J., Hanlon, D., & Anderson, C. H. (2001). An integrated software suite for surface-based analyses of cerebral cortex. Journal of the American Medical Informatics Association, 8(5), 443–459. CrossRef Van Essen, D. C., Drury, H. A., Dickson, J., Harwell, J., Hanlon, D., & Anderson, C. H. (2001). An integrated software suite for surface-based analyses of cerebral cortex. Journal of the American Medical Informatics Association, 8(5), 443–459. CrossRef
go back to reference Wei, L., Zhong, S., Nie, S., & Gong, G. (2018). Aberrant development of the asymmetry between hemispheric brain white matter networks in autism spectrum disorder. European Neuropsychopharmacology, 28(1), 48–62. CrossRef Wei, L., Zhong, S., Nie, S., & Gong, G. (2018). Aberrant development of the asymmetry between hemispheric brain white matter networks in autism spectrum disorder. European Neuropsychopharmacology, 28(1), 48–62. CrossRef
Metagegevens
Titel
Autism Spectrum Disorder Symptoms are Associated with Connectivity Between Large-Scale Neural Networks and Brain Regions Involved in Social Processing
Auteurs
Korey P. Wylie
Jason R. Tregellas
Joshua J. Bear
Kristina T. Legget
Publicatiedatum
31-01-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04383-w