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01-04-2007 | Artikelen

Microvasculaire schade en cognitieve achteruitgang bij type-1-diabetes

Auteurs: Alette Wessels, Frank Snoek, Frederik Barkhof, Robert Heine

Gepubliceerd in: Neuropraxis | Uitgave 2/2007

Abstract

Type-1-diabetes is een stofwisselingsziekte die wordt gekenmerkt door een chronisch verhoogde bloedglucosespiegel (hyperglykemie) als gevolg van een insulinesecretiedefect. De behandeling bestaat uit het meermalen daags toedienen van insuline. Ondanks de beschikbaarheid van diverse soorten insuline en moderne toedieningsystemen en technieken om thuis de bloedglucosewaarden te controleren, ervaren patiënten fluctuaties in hun bloedglucosespiegel, variërend van hypoglykemie (lage bloedglucosewaarden) tot hyperglykemie. Langdurige hyperglykemie is verantwoordelijk voor het ontstaan van microvasculaire complicaties, zoals retinopathie, nefropathie en perifere neuropathie. Onbekend is of microvasculaire schade zich ook in het brein manifesteert.

vorige artikel Axonale schade bij multiple sclerose: oorzaken en biologische markerstoffen

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Titel: Microvasculaire schade en cognitieve achteruitgang bij type-1-diabetes
Auteurs: Alette Wessels
Frank Snoek
Frederik Barkhof
Robert Heine
Publicatiedatum: 01-04-2007
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Neuropraxis / Uitgave 2/2007
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI: https://doi.org/10.1007/BF03079121

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