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Gepubliceerd in: Journal of Behavioral Medicine 6/2018

17-05-2018

Methamphetamine-associated dysregulation of the hypothalamic–pituitary–thyroid axis

Auteurs: Deborah L. Jones, Adam W. Carrico, Suat Babayigit, Violeta J. Rodriguez, Carlos Aguila, Mahendra Kumar

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2018

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Abstract

Methamphetamine and HIV impair thyroid function, but few studies have investigated their combined effects on thyroid dysregulation. This study examined the associations of methamphetamine use alone and in combination with HIV on thyroid function among men in South Florida. Measures of thyroid function in methamphetamine-using, HIV-infected (METH+HIV+; n = 127) and HIV-negative (METH+HIV−; n = 46) men who have sex with men (MSM) were compared to non-methamphetamine-using, HIV-negative men (METH−HIV−; n = 136). Thyroid function was dysregulated in methamphetamine-using MSM, irrespective of HIV status. Both meth-using groups had greater odds of abnormal thyroid stimulating hormone levels and significantly higher mean free triiodothyronine (T3) levels. Elevated free T3 was associated with greater depressive symptoms. Overall, outcomes have important implications for assessment of thyroid function in methamphetamine users, particularly among those presenting with depression.
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Metagegevens
Titel
Methamphetamine-associated dysregulation of the hypothalamic–pituitary–thyroid axis
Auteurs
Deborah L. Jones
Adam W. Carrico
Suat Babayigit
Violeta J. Rodriguez
Carlos Aguila
Mahendra Kumar
Publicatiedatum
17-05-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 6/2018
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-018-9935-6

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