Skip to main content
Top
Gepubliceerd in: Mindfulness 6/2020

02-03-2020 | REVIEW

The Relationship Between Doses of Mindfulness-Based Programs and Depression, Anxiety, Stress, and Mindfulness: a Dose-Response Meta-Regression of Randomized Controlled Trials

Auteur: Sarah Strohmaier

Gepubliceerd in: Mindfulness | Uitgave 6/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Objectives

Research with mindfulness-based programs (MBPs) has found participating in an MBP to predict beneficial outcomes; however, there is currently mixed research regarding the most helpful dose. This review aimed to determine whether different doses related to MBPs significantly predict outcomes.

Methods

Systematic literature searches of electronic databases and trial registration sites for all randomized controlled trials of MBPs identified 203 studies (N = 15,971). Depression was the primary outcome at post-program and follow-up, with secondary outcomes being mindfulness, anxiety and stress. Doses examined related to session numbers, duration and length, facilitator contact and practice. Dose-response relationships were analyzed using meta-regression in R with separate analyses for inactive and active controls.

Results

Initial meta-analyses found significant between-group differences favoring MBPs for all outcomes. Meta-regression results suggested significant dose-response relationships for the mindfulness outcome for doses relating to face-to-face contact (d = 0.211; C.I.[0.064,0.358]), program intensity (d = 0.895; C.I.[0.315,1.474]) and actual program use (d = 0.013; C.I.[0.001,0.024]). The majority of results for psychological outcomes, including depression, were not significant.

Conclusions

This meta-regression examines dose-response relationships for different types and doses relating to MBPs. Considered together, MBPs appeared helpful compared with controls, supporting previous research. Based on meta-regression results, there was no evidence that larger doses are more helpful than smaller doses for predicting psychological outcomes; a finding consistent with some previous research particularly with non-clinical populations. Additionally, greater contact, intensity and actual use of MBPs predicting increased mindfulness correspond with previous research and theory. Potential limitations and recommendations for future research are explored.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Abdi, H. (2010). Holm's sequential Bonferroni procedure. In N. Salkind (Ed.), Encyclopedia of research design. Sage. Abdi, H. (2010). Holm's sequential Bonferroni procedure. In N. Salkind (Ed.), Encyclopedia of research design. Sage.
go back to reference Beblo, T., & Schulte, J. (2017). Mindfulness: more practice – better results? Neurology and Rehabilitation, 23(1), 19–26. Beblo, T., & Schulte, J. (2017). Mindfulness: more practice – better results? Neurology and Rehabilitation, 23(1), 19–26.
go back to reference Berlin, J. A., Santanna, J., Schmid, C. H., Szczech, L. A., & Feldman, H. I. (2002). Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head. Statistics in Medicine, 21(3), 371–387. https://doi.org/10.1002/sim.1023.CrossRefPubMed Berlin, J. A., Santanna, J., Schmid, C. H., Szczech, L. A., & Feldman, H. I. (2002). Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head. Statistics in Medicine, 21(3), 371–387. https://​doi.​org/​10.​1002/​sim.​1023.CrossRefPubMed
go back to reference Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to meta-analysis. John Wiley & Sons. Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to meta-analysis. John Wiley & Sons.
go back to reference Chang, V. Y., Palesh, O., Caldwell, R., Glasgow, N., Abramson, M., Luskin, F., Gill, M., Burke, A., & Koopman, C. (2004). The effects of a mindfulness-based stress reduction program on stress, mindfulness self-efficacy, and positive states of mind. Stress and Health: Journal of the International Society for the Investigation of Stress, 20, 141–147. https://doi.org/10.1002/smi.1011.CrossRef Chang, V. Y., Palesh, O., Caldwell, R., Glasgow, N., Abramson, M., Luskin, F., Gill, M., Burke, A., & Koopman, C. (2004). The effects of a mindfulness-based stress reduction program on stress, mindfulness self-efficacy, and positive states of mind. Stress and Health: Journal of the International Society for the Investigation of Stress, 20, 141–147. https://​doi.​org/​10.​1002/​smi.​1011.CrossRef
go back to reference Clark-Carter, D. (1997). Doing quantitative psychological research: from design to report. Taylor & Francis. Clark-Carter, D. (1997). Doing quantitative psychological research: from design to report. Taylor & Francis.
go back to reference Dimidjian, S., Goodman, S. H., Felder, J. N., Gallop, R., Brown, A. P., & Beck, A. (2016). Staying well during pregnancy and the postpartum: a pilot randomized trial of mindfulness-based cognitive therapy for the prevention of depressive relapse/recurrence. Journal of Consulting and Clinical Psychology, 84(2), 134–145. https://doi.org/10.1037/ccp0000068.CrossRefPubMed Dimidjian, S., Goodman, S. H., Felder, J. N., Gallop, R., Brown, A. P., & Beck, A. (2016). Staying well during pregnancy and the postpartum: a pilot randomized trial of mindfulness-based cognitive therapy for the prevention of depressive relapse/recurrence. Journal of Consulting and Clinical Psychology, 84(2), 134–145. https://​doi.​org/​10.​1037/​ccp0000068.CrossRefPubMed
go back to reference Fu, R., Gartlehner, G., Grant, M., Shamliyan, T., Sedrakyan, A., Wilt, T. J., Griffith, L., Oremus, M., Raina, P., Ismaila, P., Santaguida, P., Lau, J., & Trikalinos, T. A. (2010, October 25). Conducting quantitative synthesis when comparing medical interventions: AHRQ and the effective health care program. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality. https://www.ncbi.nlm.nih.gov/pubmed/21433407 Fu, R., Gartlehner, G., Grant, M., Shamliyan, T., Sedrakyan, A., Wilt, T. J., Griffith, L., Oremus, M., Raina, P., Ismaila, P., Santaguida, P., Lau, J., & Trikalinos, T. A. (2010, October 25). Conducting quantitative synthesis when comparing medical interventions: AHRQ and the effective health care program. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality. https://​www.​ncbi.​nlm.​nih.​gov/​pubmed/​21433407
go back to reference Glenn, D., Gilinelli, D., Rose, R. D., Roy-Byrne, P., Stein, M. B., Sullivan, G., Bystritksy, A., Sherbourne, C., & Craske, M. G. (2013). Who gets the most out of cognitive-behavioral therapy for anxiety disorders? The role of treatment dose and patient engagement. Journal of Consulting and Clinical Psychology, 81(4), 639–649. https://doi.org/10.1037/a0033403.CrossRefPubMedPubMedCentral Glenn, D., Gilinelli, D., Rose, R. D., Roy-Byrne, P., Stein, M. B., Sullivan, G., Bystritksy, A., Sherbourne, C., & Craske, M. G. (2013). Who gets the most out of cognitive-behavioral therapy for anxiety disorders? The role of treatment dose and patient engagement. Journal of Consulting and Clinical Psychology, 81(4), 639–649. https://​doi.​org/​10.​1037/​a0033403.CrossRefPubMedPubMedCentral
go back to reference Hedges, L. V., & Olkin, I. (1985). Statistical methods for meta-analysis. Academic Press. Hedges, L. V., & Olkin, I. (1985). Statistical methods for meta-analysis. Academic Press.
go back to reference Higgins, J. P. T., & Green, S. (2008). Cochrane handbook for systematic reviews of interventions. John Wiley & Sons. Higgins, J. P. T., & Green, S. (2008). Cochrane handbook for systematic reviews of interventions. John Wiley & Sons.
go back to reference Holm, S. (1979). A simple sequential rejective multiple test procedure. Scandinavian Journal of Statistics, 6, 65–70. Holm, S. (1979). A simple sequential rejective multiple test procedure. Scandinavian Journal of Statistics, 6, 65–70.
go back to reference Kabat-Zinn, J. (1990). Full catastrophe living. Dell Publishing. Kabat-Zinn, J. (1990). Full catastrophe living. Dell Publishing.
go back to reference Kabat-Zinn, J. (2005). Coming to our senses: healing ourselves and the world through mindfulness. Hyperion. Kabat-Zinn, J. (2005). Coming to our senses: healing ourselves and the world through mindfulness. Hyperion.
go back to reference Kabat-Zinn, J. (2013). Full catastrophe living, revised edition: how to cope with stress, pain and illness using mindfulness meditation. Hachette. Kabat-Zinn, J. (2013). Full catastrophe living, revised edition: how to cope with stress, pain and illness using mindfulness meditation. Hachette.
go back to reference Kubo, A., Kurtovich, E., McGinnis, M., Aghee, A., Altschuler, A., Quesenberry, C., Kolevska, T., & Avins, A. L. (2019). A randomized controlled trial of mhealth mindfulness intervention for cancer patients and informal cancer caregivers: a feasibility study within an integrated health care delivery system. Integrative Cancer Therapies, 18, 1–13. https://doi.org/10.1177/1534735419850634.CrossRef Kubo, A., Kurtovich, E., McGinnis, M., Aghee, A., Altschuler, A., Quesenberry, C., Kolevska, T., & Avins, A. L. (2019). A randomized controlled trial of mhealth mindfulness intervention for cancer patients and informal cancer caregivers: a feasibility study within an integrated health care delivery system. Integrative Cancer Therapies, 18, 1–13. https://​doi.​org/​10.​1177/​1534735419850634​.CrossRef
go back to reference Kuyken, W., Byford, S., Taylor, R. S., Watkins, E., Holden, E., White, K., Barrett, B., Byng, R., Evans, A., Mullan, E., & Teasdale, J. D. (2008). Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. Journal of Consulting and Clinical Psychology, 76(6), 966–978. https://doi.org/10.1037/a0013786.CrossRefPubMed Kuyken, W., Byford, S., Taylor, R. S., Watkins, E., Holden, E., White, K., Barrett, B., Byng, R., Evans, A., Mullan, E., & Teasdale, J. D. (2008). Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. Journal of Consulting and Clinical Psychology, 76(6), 966–978. https://​doi.​org/​10.​1037/​a0013786.CrossRefPubMed
go back to reference Kuyken, W., Warren, F. C., Taylor, R. S., Whalley, B., Crane, C., Bondolfi, G., Hayes, R., Huijbers, M., Ma, H., Schweizer, S., Segal, Z., Speckens, A., Teasdale, J. D., van Heeringen, K., Williams, M., Byford, S., Byng, R., & Dalgleish, T. (2016). Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse: an individual patient data meta-analysis from randomized trials. JAMA Psychiatry, 73(6), 565–574. https://doi.org/10.1001/jamapsychiatry.2016.0076.CrossRefPubMed Kuyken, W., Warren, F. C., Taylor, R. S., Whalley, B., Crane, C., Bondolfi, G., Hayes, R., Huijbers, M., Ma, H., Schweizer, S., Segal, Z., Speckens, A., Teasdale, J. D., van Heeringen, K., Williams, M., Byford, S., Byng, R., & Dalgleish, T. (2016). Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse: an individual patient data meta-analysis from randomized trials. JAMA Psychiatry, 73(6), 565–574. https://​doi.​org/​10.​1001/​jamapsychiatry.​2016.​0076.CrossRefPubMed
go back to reference Lacaille, J., Sadikaj, G., Nishioka, M., Carriere, K., Flanders, J., & Knaeuper, B. (2018). Daily mindful responding mediates the effect of meditation practice on stress and mood: the role of practice duration and adherence. Journal of Clinical Psychology, 74(1), 109–122. https://doi.org/10.1002/jclp.22489.CrossRefPubMed Lacaille, J., Sadikaj, G., Nishioka, M., Carriere, K., Flanders, J., & Knaeuper, B. (2018). Daily mindful responding mediates the effect of meditation practice on stress and mood: the role of practice duration and adherence. Journal of Clinical Psychology, 74(1), 109–122. https://​doi.​org/​10.​1002/​jclp.​22489.CrossRefPubMed
go back to reference Langer, E. (2014). Mindfulness (25th Anniversary ed.). Da Calp Press. Langer, E. (2014). Mindfulness (25th Anniversary ed.). Da Calp Press.
go back to reference Lu, S. (2015). Mindfulness holds promise for treating depression: new research suggests that practicing mindfulness may help prevent a relapse. American Psychological Association, 46(3), 50. Lu, S. (2015). Mindfulness holds promise for treating depression: new research suggests that practicing mindfulness may help prevent a relapse. American Psychological Association, 46(3), 50.
go back to reference Schellekens, M. P. J., van den Hurk, D. G. M., Prins, J. B., Donders, A. R. T., Molema, J., Dekhuijzen, R., van der Drift, M. A., & Speckens, A. E. M. (2017). Mindfulness-based stress reduction added to care as usual for lung cancer patients and/or their partners: a multicentre randomized controlled trial. Psycho-Oncology, 26, 2118–2126. https://doi.org/10.1002/pon.4430.CrossRefPubMed Schellekens, M. P. J., van den Hurk, D. G. M., Prins, J. B., Donders, A. R. T., Molema, J., Dekhuijzen, R., van der Drift, M. A., & Speckens, A. E. M. (2017). Mindfulness-based stress reduction added to care as usual for lung cancer patients and/or their partners: a multicentre randomized controlled trial. Psycho-Oncology, 26, 2118–2126. https://​doi.​org/​10.​1002/​pon.​4430.CrossRefPubMed
go back to reference Schwarzer, G. (2007). Meta: an R package for meta-analysis. R News, 7(3), 40–45. Schwarzer, G. (2007). Meta: an R package for meta-analysis. R News, 7(3), 40–45.
go back to reference Segal, Z. V., Williams, M. G., & Teasdale, J. D. (2002). Mindfulness-based cognitive therapy for depression: a new approach to preventing relapse. Guildford Press. Segal, Z. V., Williams, M. G., & Teasdale, J. D. (2002). Mindfulness-based cognitive therapy for depression: a new approach to preventing relapse. Guildford Press.
go back to reference The Cochrane Collaboration. (2012). Review manager (RevMan) (version 5.2) [computer program]. Copenhagen: The Nordic Cochrane Centre. The Cochrane Collaboration. (2012). Review manager (RevMan) (version 5.2) [computer program]. Copenhagen: The Nordic Cochrane Centre.
go back to reference van Dam, N. T., van Vugt, M. K., Vago, D. R., Schmalzl, L., Saron, C. D., Olendzki, A., Meissner, T., Lazar, S. W., Kerr, C. E., Gorchov, J., Fox, K. C. R., Field, B. A., Britton, W. B., Brefczynski-Lewis, J. A., & Meyer, D. E. (2018). Mind the hype: a critical evaluation and prescriptive agenda for research on mindfulness and meditation. Perspectives on Psychological Science, 13(1), 36–61. https://doi.org/10.1177/1745691617709589.CrossRefPubMed van Dam, N. T., van Vugt, M. K., Vago, D. R., Schmalzl, L., Saron, C. D., Olendzki, A., Meissner, T., Lazar, S. W., Kerr, C. E., Gorchov, J., Fox, K. C. R., Field, B. A., Britton, W. B., Brefczynski-Lewis, J. A., & Meyer, D. E. (2018). Mind the hype: a critical evaluation and prescriptive agenda for research on mindfulness and meditation. Perspectives on Psychological Science, 13(1), 36–61. https://​doi.​org/​10.​1177/​1745691617709589​.CrossRefPubMed
go back to reference Wickham, H. (2009). ggplot2: elegant graphics for data analysis. Springer-Verlag. Wickham, H. (2009). ggplot2: elegant graphics for data analysis. Springer-Verlag.
go back to reference Yalom, I. D. (1983). Inpatient group psychotherapy. Basic Books. Yalom, I. D. (1983). Inpatient group psychotherapy. Basic Books.
go back to reference Zautra, A. J., Davis, M. C., Reich, J. W., Nicassio, P., Tennen, H., Finan, P., Kratz, A., Parrish, B., & Irwin, M. R. (2008). Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. Journal of Consulting and Clinical Psychology, 76(3), 408–421. https://doi.org/10.1037/0022-006X.76.3.408.CrossRefPubMed Zautra, A. J., Davis, M. C., Reich, J. W., Nicassio, P., Tennen, H., Finan, P., Kratz, A., Parrish, B., & Irwin, M. R. (2008). Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. Journal of Consulting and Clinical Psychology, 76(3), 408–421. https://​doi.​org/​10.​1037/​0022-006X.​76.​3.​408.CrossRefPubMed
Metagegevens
Titel
The Relationship Between Doses of Mindfulness-Based Programs and Depression, Anxiety, Stress, and Mindfulness: a Dose-Response Meta-Regression of Randomized Controlled Trials
Auteur
Sarah Strohmaier
Publicatiedatum
02-03-2020
Uitgeverij
Springer US
Gepubliceerd in
Mindfulness / Uitgave 6/2020
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI
https://doi.org/10.1007/s12671-020-01319-4

Andere artikelen Uitgave 6/2020

Mindfulness 6/2020 Naar de uitgave

ORTHOGONAL ROTATION IN CONSCIOUSNESS

“I Read the News Today, Oh Boy”