Skip to main content
Top
Gepubliceerd in:

30-03-2020 | ORIGINAL PAPER

Comprehensive Metabolomic and Lipidomic Analysis Reveals Metabolic Changes After Mindfulness Training

Auteurs: Wei Chen, Jing Zeng, Wen Wang, Bin Yang, Lijun Zhong, Juntuo Zhou

Gepubliceerd in: Mindfulness | Uitgave 6/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Objectives

Mindfulness is a subtype of meditation. Increasing evidence suggests that trainers benefit mental and physical health improvement, but the mechanism and molecular changes of mindfulness have not been elucidated. We aim to find the metabolomic and lipidomic changes in serum after mindfulness trainings and to study how mindfulness affect body metabolism.

Methods

We performed liquid chromatography-mass spectrometry-based metabolomics and lipidomics to systematically analyze the changed metabolites after mindfulness trainings. Participants (n = 27) who joined a 5-day intensive mindfulness training retreat and participants (n = 14) who joined a 5-day mindfulness training retreat in dark ambiance were recruited in the study. Serum samples of each trainer before and after mindfulness training were collected and analyzed. Statistical analysis and bioinformatics were carried out by MetaboAnalyst web service.

Results

Statistical analysis revealed that 22 metabolites were dysregulated in serum after mindfulness trainings. Pathway enrichment analysis showed that several metabolic pathways were significantly perturbed, such as arginine and proline metabolism, nitrogen metabolism, and histidine metabolism. Lipidomic analysis revealed 378 dysregulated lipids totally in two mindfulness trainings. Among these lipids, most of the lipid species showed trends of upregulation, such as Cer, PC, PE, LPC, LPE, and TAG, while a few lipid species showed trends of downregulation, such as SM, OxFA, and OxPC.

Conclusions

Our study highlights a comprehensive view of metabolic and lipidomic changes related to mindfulness trainings, providing clues on influence of mindfulness meditation on body metabolism.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., & Ferris, J. L. (2016). Alterations in resting-state functional connectivity link mindfulness meditation with reduced interleukin-6: a randomized controlled trial. Biological Psychiatry, 80(1), 53–61. https://doi.org/10.1016/j.biopsych.2016.01.008.CrossRefPubMed Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., & Ferris, J. L. (2016). Alterations in resting-state functional connectivity link mindfulness meditation with reduced interleukin-6: a randomized controlled trial. Biological Psychiatry, 80(1), 53–61. https://​doi.​org/​10.​1016/​j.​biopsych.​2016.​01.​008.CrossRefPubMed
go back to reference Kabat-Zinn, J. (2009). Wherever you go, there you are: mindfulness meditation in everyday life. New York: Hachette Books. Kabat-Zinn, J. (2009). Wherever you go, there you are: mindfulness meditation in everyday life. New York: Hachette Books.
go back to reference Kang, D.-H., Jo, H. J., Jung, W. H., Kim, S. H., Jung, Y.-H., Choi, C.-H., Lee, U. S., An, S. C., Jang, J. H., & Kwon, J. S. (2013). The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Social Cognitive and Affective Neuroscience, 8(1), 27–33. https://doi.org/10.1093/scan/nss056.CrossRefPubMed Kang, D.-H., Jo, H. J., Jung, W. H., Kim, S. H., Jung, Y.-H., Choi, C.-H., Lee, U. S., An, S. C., Jang, J. H., & Kwon, J. S. (2013). The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Social Cognitive and Affective Neuroscience, 8(1), 27–33. https://​doi.​org/​10.​1093/​scan/​nss056.CrossRefPubMed
go back to reference Luo, P., Yin, P., Hua, R., Tan, Y., Li, Z., Qiu, G., Yin, Z., Xie, X., Wang, X., Chen, W., Zhou, L., Wang, X., Li, Y., Chen, H., Gao, L., Lu, X., Wu, T., Wang, H., Niu, J., & Xu, G. (2018). A large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma. Hepatology, 67(2), 662–675. https://doi.org/10.1002/hep.29561.CrossRefPubMed Luo, P., Yin, P., Hua, R., Tan, Y., Li, Z., Qiu, G., Yin, Z., Xie, X., Wang, X., Chen, W., Zhou, L., Wang, X., Li, Y., Chen, H., Gao, L., Lu, X., Wu, T., Wang, H., Niu, J., & Xu, G. (2018). A large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma. Hepatology, 67(2), 662–675. https://​doi.​org/​10.​1002/​hep.​29561.CrossRefPubMed
go back to reference Ospina, M. B., Bond, K., Karkhaneh, M., Tjosvold, L., Vandermeer, B., Liang, Y., Bialy, L., Hooton, N., Buscemi, N., Dryden, D. M., & Klassen, T. P. (2007). Meditation practices for health: state of the research. Evidence Report/Technology Assessment, 155, 1–263. Ospina, M. B., Bond, K., Karkhaneh, M., Tjosvold, L., Vandermeer, B., Liang, Y., Bialy, L., Hooton, N., Buscemi, N., Dryden, D. M., & Klassen, T. P. (2007). Meditation practices for health: state of the research. Evidence Report/Technology Assessment, 155, 1–263.
go back to reference Pete, M. J., Ross, A. H., & Exton, J. H. (1994). Purification and properties of phospholipase A1 from bovine brain. The Journal of Biological Chemistry, 269(30), 19494–19500. Pete, M. J., Ross, A. H., & Exton, J. H. (1994). Purification and properties of phospholipase A1 from bovine brain. The Journal of Biological Chemistry, 269(30), 19494–19500.
go back to reference Rosenberg, E. L., Zanesco, A. P., King, B. G., Aichele, S. R., Jacobs, T. L., Bridwell, D. A., MacLean, K. A., Shaver, P. R., Ferrer, E., Sahdra, B. K., Lavy, S., Wallace, B. A., & Saron, C. D. (2015). Intensive meditation training influences emotional responses to suffering. Emotion, 15(6), 775–790. https://doi.org/10.1037/emo0000080.CrossRefPubMed Rosenberg, E. L., Zanesco, A. P., King, B. G., Aichele, S. R., Jacobs, T. L., Bridwell, D. A., MacLean, K. A., Shaver, P. R., Ferrer, E., Sahdra, B. K., Lavy, S., Wallace, B. A., & Saron, C. D. (2015). Intensive meditation training influences emotional responses to suffering. Emotion, 15(6), 775–790. https://​doi.​org/​10.​1037/​emo0000080.CrossRefPubMed
go back to reference Segal, Z. V., Williams, J. M. G., & Teasdale, J. (2018). Mindfulness-based cognitive therapy for depression. New York: Guilford Publications. Segal, Z. V., Williams, J. M. G., & Teasdale, J. (2018). Mindfulness-based cognitive therapy for depression. New York: Guilford Publications.
go back to reference Van Vugt, M. K. (2015). Cognitive benefits of mindfulness meditation. In K. W. Brown, J. D. Creswell, & R, M. Ryan (Eds.), Handbook of mindfulness: theory, research, and practice (pp. 190–207). New York: Guilford. Van Vugt, M. K. (2015). Cognitive benefits of mindfulness meditation. In K. W. Brown, J. D. Creswell, & R, M. Ryan (Eds.),  Handbook of mindfulness: theory, research, and practice (pp. 190–207). New York: Guilford.
Metagegevens
Titel
Comprehensive Metabolomic and Lipidomic Analysis Reveals Metabolic Changes After Mindfulness Training
Auteurs
Wei Chen
Jing Zeng
Wen Wang
Bin Yang
Lijun Zhong
Juntuo Zhou
Publicatiedatum
30-03-2020
Uitgeverij
Springer US
Gepubliceerd in
Mindfulness / Uitgave 6/2020
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI
https://doi.org/10.1007/s12671-020-01359-w