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Gepubliceerd in: Neuropraxis 5/2008

01-10-2008 | Artikelen

Kunnen neurale stamcellen de overleving van neuronen in post mortem hersenweefselkweken stimuleren?

Auteur: Ronald Verwer

Gepubliceerd in: Neuropraxis | Uitgave 5/2008

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Samenvatting

Stamcellen worden beschouwd als de meest veelbelovende bron om cellen te vervangen bij uiteenlopende ziekten waarbij cellen degenereren of doodgaan. Bij de ziekte van Alzheimer vindt door het hele brein degeneratie van cellen plaats. In zo'n geval is celvervanging minder voor de hand liggend. Maar als stamcellen factoren uitscheiden die de degenererende cellen helpen te overleven, zouden op basis daarvan therapeutische strategieën ontwikkeld kunnen worden.
Literatuur
go back to reference Boekhoorn, K., Joels, M. & Lucassen, P.J. (2006). Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease, 24, 1—14. Boekhoorn, K., Joels, M. & Lucassen, P.J. (2006). Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease, 24, 1—14.
go back to reference Curtis, M.A., Penney, E.B., Pearson, A.G., van Roon-Mom, W.M.C., Butterworth, N.J., Dragunow, M., Connor, B, & Faull, R.L.M. (2003). Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain. Proceedings of the National Academy of Sciences of the USA, 100, 9023–9027. Curtis, M.A., Penney, E.B., Pearson, A.G., van Roon-Mom, W.M.C., Butterworth, N.J., Dragunow, M., Connor, B, & Faull, R.L.M. (2003). Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain. Proceedings of the National Academy of Sciences of the USA, 100, 9023–9027.
go back to reference Englund, U., Björlund, A., Wictorin, K., Lindvall, O. & Kokaia, M. (2002). Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proceedings of the National Academy of Sciences of the USA, 99, 17089–17094. Englund, U., Björlund, A., Wictorin, K., Lindvall, O. & Kokaia, M. (2002). Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proceedings of the National Academy of Sciences of the USA, 99, 17089–17094.
go back to reference Eriksson, P.S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A., Nordborg, C., Peterson, D.A. & Gage F.H. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 1—5. Eriksson, P.S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A., Nordborg, C., Peterson, D.A. & Gage F.H. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 1—5.
go back to reference Falini, A., Bozzali, M., Magnani, G., Pero, G., Gambini, A., Benedetti, B., Mossini, R., Franceschi, M., Comi, G., Scotti, G. & Filippi, M. (2005). A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. Neuroimage, 26, 1159–1163. Falini, A., Bozzali, M., Magnani, G., Pero, G., Gambini, A., Benedetti, B., Mossini, R., Franceschi, M., Comi, G., Scotti, G. & Filippi, M. (2005). A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. Neuroimage, 26, 1159–1163.
go back to reference Jin, K., Peel, A.L., Mao, X.O., Xie, L., Cottrel, B.A., Henshall, D.C. & Greenberg, D.A. (2004). Increased hippocampal neurogenesis in Alzheimer's disease. Proceedings of the National Academy of Sciences of the USA, 101, 343–347. Jin, K., Peel, A.L., Mao, X.O., Xie, L., Cottrel, B.A., Henshall, D.C. & Greenberg, D.A. (2004). Increased hippocampal neurogenesis in Alzheimer's disease. Proceedings of the National Academy of Sciences of the USA, 101, 343–347.
go back to reference Lindvall, O., Kokaia Z. & Martinez-Serrano, A. (2004). Stem cell therapy for human neurodegenerative disorders — how to make it work. Nature Medicine, 10, S42–50. Lindvall, O., Kokaia Z. & Martinez-Serrano, A. (2004). Stem cell therapy for human neurodegenerative disorders — how to make it work. Nature Medicine, 10, S42–50.
go back to reference Lindvall, O. & Kokaia, Z. (2006). Stem cells for the treatment of neurological disorders. Nature, 441, 1094–1096. Lindvall, O. & Kokaia, Z. (2006). Stem cells for the treatment of neurological disorders. Nature, 441, 1094–1096.
go back to reference Ostenfeld, T., Joly, E., Tai, Y-T., Peters, A., Caldwell, M., Jauniaux, E. & Svendsen, C.N. (2002). Regional specification of rodent and human neurospheres. Developmental Brain Research, 34, 43–55. Ostenfeld, T., Joly, E., Tai, Y-T., Peters, A., Caldwell, M., Jauniaux, E. & Svendsen, C.N. (2002). Regional specification of rodent and human neurospheres. Developmental Brain Research, 34, 43–55.
go back to reference Ourednik, J., Ourednik, V., Lynch, W.P., Schachne, M. & Snyder, E.Y. (2002). Neural stem cells display an inherent mechanism for rescueing dysfunctional neurons. Nature Biotechnology, 20, 1103–1110. Ourednik, J., Ourednik, V., Lynch, W.P., Schachne, M. & Snyder, E.Y. (2002). Neural stem cells display an inherent mechanism for rescueing dysfunctional neurons. Nature Biotechnology, 20, 1103–1110.
go back to reference Passier, R. & Mummery, C. (2003). Origin and use of embryonic and adult stem cells in differentiation and tissue repair. Cardiovascular Research, 58, 324–335. Passier, R. & Mummery, C. (2003). Origin and use of embryonic and adult stem cells in differentiation and tissue repair. Cardiovascular Research, 58, 324–335.
go back to reference Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Del Caro, U., Amadio, S., Bergam, A., Furlan, R., Comi, G., Vescovi, A.L. & Martino, G. (2003). Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature, 422, 688–694. Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Del Caro, U., Amadio, S., Bergam, A., Furlan, R., Comi, G., Vescovi, A.L. & Martino, G. (2003). Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature, 422, 688–694.
go back to reference Sanai, N,. Tramontin, A.D., Quinones-Hinojosa, A., Barbaro, N.M., Gupta, N., Kunwar, S., Lawton, M.T., McDermott, M.W., Parsa, A.T., Garcia-Verdugo, J.M., Berger, M.S. & Alvarez-Buylla, A. (2004). Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature, 427, 740—744. Sanai, N,. Tramontin, A.D., Quinones-Hinojosa, A., Barbaro, N.M., Gupta, N., Kunwar, S., Lawton, M.T., McDermott, M.W., Parsa, A.T., Garcia-Verdugo, J.M., Berger, M.S. & Alvarez-Buylla, A. (2004). Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature, 427, 740—744.
go back to reference Swaab, D.F., Dubelaar, E.J.G., Hofman, M.A., Scherder, E.J.A., Someren, E.J.W. van & Verwer, R.W.H. (2002). Brain aging and Alzheimer's disease; use it or lose it. Progress in Brain Research, 138, 343–373. Swaab, D.F., Dubelaar, E.J.G., Hofman, M.A., Scherder, E.J.A., Someren, E.J.W. van & Verwer, R.W.H. (2002). Brain aging and Alzheimer's disease; use it or lose it. Progress in Brain Research, 138, 343–373.
go back to reference Verwer, R.W.H., Hermens, W.T.M.C., Dijkhuizen, P.A., Ter Brake, O., Baker, R.E., Salehi, A., Sluiter, A.A., Kok, M.J.M., Müller, L.J., Verhaagen, J. & Swaab, D.F.. (2002). Cells in human postmortem brain tissue slices remain alive for several weeks in culture. FASEB Journal, 16, 54–60. Verwer, R.W.H., Hermens, W.T.M.C., Dijkhuizen, P.A., Ter Brake, O., Baker, R.E., Salehi, A., Sluiter, A.A., Kok, M.J.M., Müller, L.J., Verhaagen, J. & Swaab, D.F.. (2002). Cells in human postmortem brain tissue slices remain alive for several weeks in culture. FASEB Journal, 16, 54–60.
go back to reference Verwer, R.W.H., Sluiter, A.A., Balesar, R.A., Baayen, J.C., Noske, D.P., Dirven, C.M.F., Wouda, J., Dam, A.M. van, Lucassen, P.J. & Swaab, D.F. (2007). Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain, 130, 3321–3335. Verwer, R.W.H., Sluiter, A.A., Balesar, R.A., Baayen, J.C., Noske, D.P., Dirven, C.M.F., Wouda, J., Dam, A.M. van, Lucassen, P.J. & Swaab, D.F. (2007). Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain, 130, 3321–3335.
go back to reference Wu, L., Sluiter, A.A., Guo, H., Balesar, R.A., Swaab, D.F., Zhou, J.N. & Verwer, R.W.H. (2008). Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients. Journal of Cellular and Molecular Medicine, (in druk: 10.1111/j.1582-4934.2007.00203.x). Wu, L., Sluiter, A.A., Guo, H., Balesar, R.A., Swaab, D.F., Zhou, J.N. & Verwer, R.W.H. (2008). Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients. Journal of Cellular and Molecular Medicine, (in druk: 10.1111/j.1582-4934.2007.00203.x).
Metagegevens
Titel
Kunnen neurale stamcellen de overleving van neuronen in post mortem hersenweefselkweken stimuleren?
Auteur
Ronald Verwer
Publicatiedatum
01-10-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 5/2008
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/BF03077140

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