In 2021, we issued a call for papers on reducing (health-related) quality of life ((HR)QL) research waste and optimizing patient-reported outcome (PRO)/(HR)QL data. As identified by Chalmers and Glasziou [
1], research waste refers to avoidable inappropriate conduct and dissemination of research. It has multiple contributing factors and is likely a spectrum of impact rather than a dichotomous categorization (e.g., a question of how much of a given study could be considered research waste). In particular, Chalmers and Glasziou highlighted "the choice of research questions; the quality of research design and methods; the adequacy of publication practices; and the quality of reports of research" [
2] as focal areas where decisions and actions of stakeholders in the research process could have negative impact. …
