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Gepubliceerd in:

15-01-2022

Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity

Auteurs: Alena Kuhlemeier, Thomas Jaki, Elizabeth Y. Jimenez, Alberta S. Kong, Hope Gill, Chi Chang, Ken Resnicow, Dawn K. Wilson, M. Lee Van Horn

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2022

Abstract

There is an increased interest in the use of personalized medicine approaches in the prevention or treatment of obesity, however, few studies have used these approaches to identify individual differences in treatment effects. The current study demonstrates the use of the predicted individual treatment effects framework to test for individual differences in the effects of the ACTION-PAC intervention, which targeted the treatment and prevention of obesity in a high school setting. We show how methods for personalized medicine can be used to test for significant individual differences in responses to an intervention and we discuss the potential and limitations of these methods. In our example, 25% of students in the preventive intervention, were predicted to have their BMI z-score reduced by 0.39 or greater, while at other end of the spectrum, 25% were predicted to have their BMI z-score increased by 0.09 or more. In this paper, we demonstrate and discuss the process of using methods for personalized medicine with interventions targeting adiposity and discuss the lessons learned from this application. Ultimately, these methods have the potential to be useful for clinicians and clients in choosing between treatment options, however they are limited in their ability to help researchers understand the mechanisms underlying these predictions.

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Titel: Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity
Auteurs: Alena Kuhlemeier
Thomas Jaki
Elizabeth Y. Jimenez
Alberta S. Kong
Hope Gill
Chi Chang
Ken Resnicow
Dawn K. Wilson
M. Lee Van Horn
Publicatiedatum: 15-01-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 2/2022
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-021-00274-2

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