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01-09-2015 | Uitgave 9/2015

Quality of Life Research 9/2015

Health-related quality of life in young survivors of childhood cancer

Quality of Life Research > Uitgave 9/2015
L. Wengenroth, M. E. Gianinazzi, C. S. Rueegg, S. Lüer, E. Bergstraesser, C. E. Kuehni, G. Michel
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The online version of this article (doi:10.​1007/​s11136-015-0961-3) contains supplementary material, which is available to authorized users.



Childhood cancer and its treatment may affect health-related quality of life (HRQoL) in childhood cancer survivors, but population-based studies in young survivors are scarce. We aimed to: (1) compare HRQoL between young survivors and population norms and (2) find factors that influence parent-reported HRQoL in survivors.


As part of the Swiss Childhood Cancer Survivor Study, a questionnaire was mailed to parents of survivors aged 8–16 years, registered in the Swiss Childhood Cancer Registry, ≥5 years after diagnosis. We used the KIDSCREEN-27 instrument to compare self- and parent-reported HRQoL between survivors (N = 425) and standardized norms in the five dimensions of physical well-being, psychological well-being, autonomy, peers and school environment (mean = 50, SD = 10). We then used multivariable linear regressions to test the influence of socio-demographic and cancer-related factors on HRQoL.


Self-reported physical well-being was comparable to norms. Other HRQoL dimensions were higher than norms, with the highest mean = 52.2 (p < 0.001) for school environment. Parent-reported HRQoL in survivors was comparable to population norms; only physical well-being was lower (mean = 47.1, p < 0.001), and school environment was higher (mean = 51.1, p = 0.035). Parent-reported HRQoL was lower for survivors of CNS tumors (physical well-being: β = −5.27, p = 0.007; psychological well-being: β = −4.39, p = 0.044; peers β = −5.17, p = 0.028), survivors of neuroblastoma (psychological well-being β = −5.20, p = 0.047), and survivors who had had a relapse (physical well-being β = −5.41, p = 0.005).


Assessing HRQoL during follow-up care, with a focus on physical well-being, specific diagnoses (e.g., CNS tumor) and late complications (e.g., relapse) might help to early identify problems and offer support to survivors with reduced HRQoL.

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