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01-08-2016

Health-related quality-of-life improvements during 98 weeks of infliximab therapy in patients with plaque-type psoriasis in real-world practice

Auteurs: N. H. Shear, M. Hartmann, M. E. Toledo-Bahena, M. Gilbert, A. Katsambas, R. Yao, Z. Popmihajlov

Gepubliceerd in: Quality of Life Research | Uitgave 8/2016

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Abstract

Purpose

We evaluated the effect of plaque-type psoriasis on health-related quality of life (HRQoL) of patients who received infliximab (IFX) in real-world clinical settings.

Methods

REALITY was a prospective, observational, open-label study of the efficacy and safety of up to 98 weeks of IFX (5 mg/kg infused at weeks 0, 2, 6, and every 8 weeks thereafter) in patients with moderate-to-severe plaque-type psoriasis. Patients with ≥25 % Psoriasis Area Severity Index (PASI) improvement (PASI 25) at week 50 were eligible for the Extended Treatment Phase (treatment to week 98). Inclusion criteria were diagnosis of plaque-type psoriasis, age ≥18 years, decision to start IFX, and patient consent. Key secondary efficacy outcomes included the Dermatologic Life Quality Index (DLQI; mean DLQI scores, attainment of DLQI 0/1), which was analyzed over 98 weeks. Post hoc analyses examined improvement in DLQI and the relationship between PASI and DLQI.

Results

In the Treatment Phase, patients (n = 516, 66.0 % men, mean age 46.4 years) had a mean baseline PASI of 18.1. Mean DLQI improved from 12.7 at baseline to 4.7 [mean change (95 % CI); −8.0 (−8.9, −7.1)] at week 50; 64.0 % (229/358) of patients improved by ≥5 DLQI points. At week 50 (n = 362), 37.6 % (95 % CI; 32.7, 42.7) achieved a DLQI of 0. In the Extended Treatment Phase, patients (n = 167, 68.3 % men, mean age 46.6 years) had a mean baseline PASI of 20.4. Mean DLQI improved from 12.3 at baseline to 2.8 at week 98 [mean change (95 % CI); −9.4 (−10.8, −8.0)]; 68.6 % (96/140) of patients improved by ≥5 DLQI points. At week 98 (n = 141), 47.5 % (95 % CI; 39.4, 55.7) achieved a DLQI of 0.

Conclusions

Patients with plaque-type psoriasis who received treatment with IFX for 50 weeks or up to 98 weeks reported substantial HRQoL improvement.
Literatuur
1.
go back to reference Ahn, C. S., Gustafson, C. J., Sandoval, L. F., Davis, S. A., & Feldman, S. R. (2013). Cost effectiveness of biologic therapies for plaque psoriasis. American Journal of Clinical Dermatology, 14, 315–326.CrossRefPubMed Ahn, C. S., Gustafson, C. J., Sandoval, L. F., Davis, S. A., & Feldman, S. R. (2013). Cost effectiveness of biologic therapies for plaque psoriasis. American Journal of Clinical Dermatology, 14, 315–326.CrossRefPubMed
2.
go back to reference Baker, E. L., Coleman, C. I., Reinhart, K. M., et al. (2012). Effect of biologic agents on non-PASI outcomes in moderate-to-severe plaque psoriasis: Systematic review and meta-analyses. Dermatology and Therapy, 2, 9.CrossRefPubMedPubMedCentral Baker, E. L., Coleman, C. I., Reinhart, K. M., et al. (2012). Effect of biologic agents on non-PASI outcomes in moderate-to-severe plaque psoriasis: Systematic review and meta-analyses. Dermatology and Therapy, 2, 9.CrossRefPubMedPubMedCentral
3.
go back to reference Basra, M. K. A., Fenech, R., Gatt, R. M., et al. (2008). The Dermatology Life Quality Index 1994–2007: A comprehensive review of validation data and clinical results. British Journal of Dermatology, 159, 997–1035. Basra, M. K. A., Fenech, R., Gatt, R. M., et al. (2008). The Dermatology Life Quality Index 1994–2007: A comprehensive review of validation data and clinical results. British Journal of Dermatology, 159, 997–1035.
4.
go back to reference Feldman, S. R., Gottlieb, A. B., Bala, M., et al. (2008). Infliximab improves health-related quality of life in the presence of comorbidities among patients with moderate-to-severe psoriasis. British Journal of Dermatology, 159, 704–710.CrossRefPubMed Feldman, S. R., Gottlieb, A. B., Bala, M., et al. (2008). Infliximab improves health-related quality of life in the presence of comorbidities among patients with moderate-to-severe psoriasis. British Journal of Dermatology, 159, 704–710.CrossRefPubMed
5.
go back to reference Finlay, A. Y., & Khan, G. K. (1994). Dermatology life quality index (DLQI)—A simple practical measure for routine clinical use. Clinical and Experimental Dermatology, 19, 210–216.CrossRefPubMed Finlay, A. Y., & Khan, G. K. (1994). Dermatology life quality index (DLQI)—A simple practical measure for routine clinical use. Clinical and Experimental Dermatology, 19, 210–216.CrossRefPubMed
6.
go back to reference Finlay, A. Y., & Ryan, T. J. (1996). Disability and handicap in dermatology. International Journal of Dermatology, 35, 305–311.CrossRefPubMed Finlay, A. Y., & Ryan, T. J. (1996). Disability and handicap in dermatology. International Journal of Dermatology, 35, 305–311.CrossRefPubMed
7.
go back to reference Fredriksson, T., & Pettersson, U. (1978). Severe psoriasis—oral therapy with a new retinoid. Dermatology, 157, 238–244.CrossRef Fredriksson, T., & Pettersson, U. (1978). Severe psoriasis—oral therapy with a new retinoid. Dermatology, 157, 238–244.CrossRef
8.
go back to reference Gottlieb, A. B., Evans, R., Li, S., et al. (2004). Infliximab induction therapy for patients with severe plaque-type psoriasis: A randomized, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology, 51, 534–542.CrossRefPubMed Gottlieb, A. B., Evans, R., Li, S., et al. (2004). Infliximab induction therapy for patients with severe plaque-type psoriasis: A randomized, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology, 51, 534–542.CrossRefPubMed
9.
go back to reference Hongbo, Y., Thomas, C. L., Harrison, M. A., Salek, M. S., & Finlay, A. Y. (2005). Translating the science of quality of life into practice: What do dermatology life quality index scores mean? Journal of Investigative Dermatology, 125, 659–664.CrossRefPubMed Hongbo, Y., Thomas, C. L., Harrison, M. A., Salek, M. S., & Finlay, A. Y. (2005). Translating the science of quality of life into practice: What do dermatology life quality index scores mean? Journal of Investigative Dermatology, 125, 659–664.CrossRefPubMed
10.
go back to reference Khilji, F. A., Gonzalez, M., Finlay, A. Y. (2002). Clinical meaning of change in Dermatology Life Quality Index scores. British Journal of Dermatology, 147(suppl 2), 50. Khilji, F. A., Gonzalez, M., Finlay, A. Y. (2002). Clinical meaning of change in Dermatology Life Quality Index scores. British Journal of Dermatology, 147(suppl 2), 50.
11.
go back to reference Krueger, G., Koo, J., Lebwohl, M., Menter, A., Stern, R. S., & Rolstad, T. (2001). The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Archives of Dermatology, 137, 280–284.PubMed Krueger, G., Koo, J., Lebwohl, M., Menter, A., Stern, R. S., & Rolstad, T. (2001). The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Archives of Dermatology, 137, 280–284.PubMed
12.
go back to reference McKenna, K. E., & Stern, R. S. (1997). The impact of psoriasis on the quality of life of patients from the 16-center PUVA follow-up cohort. Journal of the American Academy of Dermatology, 36(3 Pt 1), 388–394.CrossRefPubMed McKenna, K. E., & Stern, R. S. (1997). The impact of psoriasis on the quality of life of patients from the 16-center PUVA follow-up cohort. Journal of the American Academy of Dermatology, 36(3 Pt 1), 388–394.CrossRefPubMed
13.
go back to reference Menter, A., & Griffiths, C. E. M. (2007). Current and future management of psoriasis. Lancet, 370, 272–284.CrossRefPubMed Menter, A., & Griffiths, C. E. M. (2007). Current and future management of psoriasis. Lancet, 370, 272–284.CrossRefPubMed
14.
go back to reference Menter, A., Feldman, S. R., Weinstein, G. D., et al. (2007). A randomized comparison of continuous versus intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis. Journal of the American Academy of Dermatology, 56(31), e1–e15.PubMed Menter, A., Feldman, S. R., Weinstein, G. D., et al. (2007). A randomized comparison of continuous versus intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis. Journal of the American Academy of Dermatology, 56(31), e1–e15.PubMed
15.
go back to reference Mrowietz, U., Kragballe, K., Reich, K., et al. (2011). Definition of treatment goals for moderate to severe psoriasis: A European consensus. Archives of Dermatological Research, 303, 1–10.CrossRefPubMed Mrowietz, U., Kragballe, K., Reich, K., et al. (2011). Definition of treatment goals for moderate to severe psoriasis: A European consensus. Archives of Dermatological Research, 303, 1–10.CrossRefPubMed
16.
go back to reference Nelson, A. A., Pearce, D. J., Fleischer, A. B, Jr, Balkrishnan, R., & Feldman, S. R. (2008). Cost-effectiveness of biologic treatments for psoriasis based on subjective and objective efficacy measures assessed over a 12-week treatment period. Journal of the American Academy of Dermatology, 58, 125–135.CrossRefPubMed Nelson, A. A., Pearce, D. J., Fleischer, A. B, Jr, Balkrishnan, R., & Feldman, S. R. (2008). Cost-effectiveness of biologic treatments for psoriasis based on subjective and objective efficacy measures assessed over a 12-week treatment period. Journal of the American Academy of Dermatology, 58, 125–135.CrossRefPubMed
17.
go back to reference Raho, G., Koleva, D. M., Garattini, L., & Naldi, L. (2012). The burden of moderate to severe psoriasis: An overview. Pharmacoeconomics, 30, 1005–1013.CrossRefPubMed Raho, G., Koleva, D. M., Garattini, L., & Naldi, L. (2012). The burden of moderate to severe psoriasis: An overview. Pharmacoeconomics, 30, 1005–1013.CrossRefPubMed
18.
go back to reference Shao, J., Jordan, D. C., & Pritchett, Y. L. (2009). Baseline observation carry forward: Reasoning, properties, and practical issues. Journal of Biopharmaceutical Statistics, 19(4), 672–684.CrossRefPubMed Shao, J., Jordan, D. C., & Pritchett, Y. L. (2009). Baseline observation carry forward: Reasoning, properties, and practical issues. Journal of Biopharmaceutical Statistics, 19(4), 672–684.CrossRefPubMed
19.
go back to reference Shear, N. H., Hartmann, M., Toledo-Bahena, M., REALITY investigators, et al. (2014). Long-term efficacy and safety of infliximab maintenance therapy in patients with plaque-type psoriasis in real-world practice. British Journal of Dermatology, 171, 631–641.CrossRefPubMed Shear, N. H., Hartmann, M., Toledo-Bahena, M., REALITY investigators, et al. (2014). Long-term efficacy and safety of infliximab maintenance therapy in patients with plaque-type psoriasis in real-world practice. British Journal of Dermatology, 171, 631–641.CrossRefPubMed
20.
go back to reference Zweegers, J., van den Reek, J. M., van de Kerkhof, P. C., et al. (2014). Comparing treatment goals for psoriasis to treatment decisions in daily practice: Results from a prospective cohort of psoriasis patients treated with biologics: BioCAPTURE. British Journal of Dermatology, 171(5), 1091–1098. doi:10.1111/bjd.13137.CrossRefPubMed Zweegers, J., van den Reek, J. M., van de Kerkhof, P. C., et al. (2014). Comparing treatment goals for psoriasis to treatment decisions in daily practice: Results from a prospective cohort of psoriasis patients treated with biologics: BioCAPTURE. British Journal of Dermatology, 171(5), 1091–1098. doi:10.​1111/​bjd.​13137.CrossRefPubMed
Metagegevens
Titel
Health-related quality-of-life improvements during 98 weeks of infliximab therapy in patients with plaque-type psoriasis in real-world practice
Auteurs
N. H. Shear
M. Hartmann
M. E. Toledo-Bahena
M. Gilbert
A. Katsambas
R. Yao
Z. Popmihajlov
Publicatiedatum
01-08-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 8/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-015-1224-z