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13-01-2023 | Original Article

Goal-Directed Learning Deficits in Patients with OCD: A Bayesian Analysis

Auteurs: Nur Hani Zainal, Joan A. Camprodon, Jennifer L. Greenberg, Aura M. Hurtado, Joshua E. Curtiss, Rebecca Matilde Berger-Gutierrez, Claire M. Gillan, Sabine Wilhelm

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 2/2023

Abstract

Introduction

Dual system learning theories posit an overreliance characterizes obsessive–compulsive disorder on habitual decision-making at the expense of goal-directed learning. However, most studies on this topic used frequentist statistics and did not evaluate the discriminant validity of goal-directed learning indices.

Methods

We recruited 55 OCD patients, used Bayesian statistics to examine goal-directed learning in OCD, and tested whether goal-directed learning indices showed discriminant validity. Patients completed self-reports, a two-stage reinforcement learning task, executive functioning (EF), and related tests (Rey Complex Figure, Wisconsin Card Sorting, Stroop tests).

Results

Analyses showed that goal-directed learning deficits were related to compulsions and self-reported OCD severity, but not obsessions, OCD-related beliefs, trait anxiety, anxiety sensitivity, or depression. Moreover, increased compulsivity and self-reported OCD (vs. all other dimensions examined) were linked to faster responses. Evidence for discriminant validity was found. Goal-directed learning coefficients were unrelated to set-shifting, inhibitory control, and visuospatial memory. Compulsivity was unrelated to memory and set-shifting but associated with poorer inhibition.

Conclusions

Findings highlight the importance of conceptualizing psychopathology dimensionally, such as the relevance of imbalanced habitual vs. goal-directed behavior in OCD. Results also underscore the importance of examining unique associations of goal-directed behaviors in OCD with clinical/syndromal measures (compulsions vs. obsessions).

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Due to space constraints, we offer details of the psychometric properties of the tests herein in Appendix A of the online supplementary materials (OSM).

Appendix E offers details on the interpretation of Bayes Factor (BF₁₀) values. Appendix F provides information on the impact of multiple testing of non-independent inter-related tests from a Bayesian perspective.

Abramovitch, A., Short, T., & Schweiger, A. (2021). The C Factor: Cognitive dysfunction as a transdiagnostic dimension in psychopathology. Clinical Psychology Review. https://doi.org/10.1016/j.cpr.2021.102007 CrossRefPubMed

Adams, T. G., Jr., Riemann, B. C., Wetterneck, C. T., & Cisler, J. M. (2012). Obsessive beliefs predict cognitive behavior therapy outcome for obsessive compulsive disorder. Cognitive Behaviour Therapy, 41(3), 203–211. https://doi.org/10.1080/16506073.2011.621969 CrossRefPubMed

Alvares, G. A., Balleine, B. W., & Guastella, A. J. (2014). Impairments in goal-directed actions predict treatment response to cognitive-behavioral therapy in social anxiety disorder. PLoS ONE, 9(4), e94778. https://doi.org/10.1371/journal.pone.0094778 CrossRefPubMedPubMedCentral

American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). APA Press. https://doi.org/10.1176/appi.books.9780890425596 CrossRef

Baldwin, S. A., & Larson, M. J. (2017). An introduction to using Bayesian linear regression with clinical data. Behaviour Research and Therapy, 98, 58–75. https://doi.org/10.1016/j.brat.2016.12.016 CrossRefPubMed

Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Manual for the Beck Depression Inventory–II. (2nd ed.). The Psychological Corporation.

Bennett, D., Sutcliffe, K., Tan, N. P., Smillie, L. D., & Bode, S. (2021). Anxious and obsessive-compulsive traits are independently associated with valuation of noninstrumental information. Journal of Experimental Psychology: General, 150(4), 739–755. https://doi.org/10.1037/xge0000966 CrossRefPubMed

Blakey, S. M., Abramowitz, J. S., Reuman, L., Leonard, R. C., & Riemann, B. C. (2017). Anxiety sensitivity as a predictor of outcome in the treatment of obsessive-compulsive disorder. Journal of Behavior Therapy and Experimental Psychiatry, 57, 113–117. https://doi.org/10.1016/j.jbtep.2017.05.003 CrossRefPubMed

Bürkner, P.-C. (2017). brms: An R package for Bayesian multilevel models using Stan. Journal of Statistical Software, 80(1), 1–28. CrossRef

Bürkner, P.-C. (2018). Advanced Bayesian multilevel modeling with the R package brms. The R Journal, 10(1), 395–411. CrossRef

Carpenter, B., Gelman, A., Hoffman, M. D., Lee, D., Goodrich, B., Betancourt, M., Brubaker, M., Guo, J., Li, P., & Riddell, A. (2017). Stan: A probabilistic programming language. Journal of Statistical Software, 76(1), 1–32. https://doi.org/10.18637/jss.v076.i01 CrossRefPubMedPubMedCentral

Cohen, J. (1988). Statistical power for the social sciences. Hillsdale, NJ: Laurence Erlbaum and Associates.

Cuttler, C., & Taylor, S. (2012). Did I forget to lock the door? The link between prospective memory failures and doubt in the compulsion to check. Journal of Experimental Psychopathology, 3(3), 437–454. https://doi.org/10.5127/jep.021811 CrossRef

Daw, N. D., Gershman, S. J., Seymour, B., Dayan, P., & Dolan, R. J. (2011). Model-based influences on humans’ choices and striatal prediction errors. Neuron, 69(6), 1204–1215. https://doi.org/10.1016/j.neuron.2011.02.027 CrossRefPubMedPubMedCentral

de Wit, S., & Dickinson, A. (2009). Associative theories of goal-directed behaviour: A case for animal-human translational models. Psychological Research Psychologische Forschung, 73(4), 463–476. https://doi.org/10.1007/s00426-009-0230-6 CrossRefPubMed

Decker, J. H., Otto, A. R., Daw, N. D., & Hartley, C. A. (2016). From creatures of habit to goal-directed learners: Tracking the developmental emergence of model-based reinforcement learning. Psychological Science, 27(6), 848–858. https://doi.org/10.1177/0956797616639301 CrossRefPubMedPubMedCentral

Denman, S. B. (1984). Denman Neuropsychology Memory Scale. S.B. Denman.

Deserno, L., Huys, Q. J., Boehme, R., Buchert, R., Heinze, H. J., Grace, A. A., & Schlagenhauf, F. (2015). Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making. Proceedings of the National Academy of Sciences, 112(5), 1595–1600. https://doi.org/10.1073/pnas.1417219112 CrossRef

Dickinson, A., & Balleine, B. (1994). Motivational control of goal-directed action. Animal Learning & Behavior, 22(1), 1–18. https://doi.org/10.3758/BF03199951 CrossRef

Diedrich, A., Sckopke, P., Schwartz, C., Schlegl, S., Osen, B., Stierle, C., & Voderholzer, U. (2016). Change in obsessive beliefs as predictor and mediator of symptom change during treatment of obsessive-compulsive disorder - a process-outcome study. BMC Psychiatry, 16, 220. https://doi.org/10.1186/s12888-016-0914-6 CrossRefPubMedPubMedCentral

Dunlap, W. P., Cortina, J. M., Vaslow, J. B., & Burke, M. J. (1996). Meta-analysis of experiments with matched groups or repeated measures designs. Psychological Methods, 1(2), 170–177. https://doi.org/10.1037/1082-989x.1.2.170 CrossRef

Exner, C., Kohl, A., Zaudig, M., Langs, G., Lincoln, T. M., & Rief, W. (2009). Metacognition and episodic memory in obsessive-compulsive disorder. Journal of Anxiety Disorders, 23(5), 624–631. https://doi.org/10.1016/j.janxdis.2009.01.010 CrossRefPubMed

First, M. B., Williams, J. B. W., Karg, R. S., & Spitzer, R. L. (2015). Structured Clinical Interview for DSM-5 Disorders. American Psychiatric Publishing, American Psychiatric Association.

Foa, E. B., Huppert, J. D., Leiberg, S., Langner, R., Kichic, R., Hajcak, G., & Salkovskis, P. M. (2002). The obsessive-compulsive inventory: development and validation of a short version. Psychological Assessment, 14(4), 485–496. https://doi.org/10.1037/1040-3590.14.4.485 CrossRefPubMed

Gelman, A., & Hill, J. (2007). Data analysis using regression and multilevel/hierarchical models. Cambridge University Press.

Gillan, C. M. (2021). Recent developments in the habit hypothesis of OCD and compulsive disorders. Current Topics in Behavioral Neurosciences, 49, 147–167. https://doi.org/10.1007/7854_2020_199 CrossRefPubMed

Gillan, C. M., Kalanthroff, E., Evans, M., Weingarden, H. M., Jacoby, R. J., Gershkovich, M., & Simpson, H. B. (2020). Comparison of the association between goal-directed planning and self-reported compulsivity vs obsessive-compulsive disorder diagnosis. JAMA Psychiatry, 77(1), 77–85. https://doi.org/10.1001/jamapsychiatry.2019.2998 CrossRefPubMed

Gillan, C. M., Kosinski, M., Whelan, R., Phelps, E. A., & Daw, N. D. (2016a). Characterizing a psychiatric symptom dimension related to deficits in goal-directed control. eLife. https://doi.org/10.7554/eLife.11305 CrossRefPubMedPubMedCentral

Gillan, C. M., Otto, A. R., Phelps, E. A., & Daw, N. D. (2015). Model-based learning protects against forming habits. Cognitive, Affective, & Behavioral Neuroscience, 15(3), 523–536. https://doi.org/10.3758/s13415-015-0347-6 CrossRef

Gillan, C. M., Papmeyer, M., Morein-Zamir, S., Sahakian, B. J., Fineberg, N. A., Robbins, T. W., & de Wit, S. (2011). Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder. American Journal of Psychiatry, 168(7), 718–726. https://doi.org/10.1176/appi.ajp.2011.10071062 CrossRefPubMed

Gillan, C. M., & Robbins, T. W. (2014). Goal-directed learning and obsessive-compulsive disorder. Philosophical Transactions of the Royal Society B. https://doi.org/10.1098/rstb.2013.0475 CrossRef

Gillan, C. M., Robbins, T. W., Sahakian, B. J., van den Heuvel, O. A., & van Wingen, G. (2016b). The role of habit in compulsivity. European Neuropsychopharmacology, 26(5), 828–840. https://doi.org/10.1016/j.euroneuro.2015.12.033 CrossRefPubMedPubMedCentral

Gillan, C. M., Vaghi, M. M., Hezemans, F. H., van Ghesel Grothe, S., Dafflon, J., Bruhl, A. B., & Robbins, T. W. (2021). Experimentally induced and real-world anxiety have no demonstrable effect on goal-directed behaviour. Psychological Medicine, 51(9), 1467–1478. https://doi.org/10.1017/S0033291720000203 CrossRefPubMed

Goodman, W. K., Price, L. H., Rasmussen, S. A., Mazure, C., Fleischmann, R. L., Hill, C. L., Heninger, G. R., & Charney, D. S. (1989). The yale-brown obsessive compulsive scale. I. Development, use, and reliability. Archives of General Psychiatry, 46(11), 1006–1011. https://doi.org/10.1001/archpsyc.1989.01810110048007 CrossRefPubMed

Graham, J. W. (2009). Missing data analysis: Making it work in the real world. Annual Review of Psychology, 60(1), 549–576. https://doi.org/10.1146/annurev.psych.58.110405.085530 CrossRefPubMed

Grant, D. A., & Berg, E. A. (1948). A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. Journal of Experimental Psychology: General, 38(4), 404–411. https://doi.org/10.1037/h0059831 CrossRef

Griffiths, K. R., Morris, R. W., & Balleine, B. W. (2014). Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders. Frontiers in Systems Neuroscience, 8, 101. https://doi.org/10.3389/fnsys.2014.00101 CrossRefPubMedPubMedCentral

Gruner, P., Anticevic, A., Lee, D., & Pittenger, C. (2016). Arbitration between action strategies in obsessive-compulsive disorder. The Neuroscientist, 22(2), 188–198. https://doi.org/10.1177/1073858414568317 CrossRefPubMed

Isobe, M., Vaghi, M., Fineberg, N. A., Apergis-Schoute, A. M., Bullmore, E. T., Sahakian, B. J., Robbins, T. W., & Chamberlain, S. R. (2021). Set-shifting-related basal ganglia deformation as a novel familial marker of obsessive-compulsive disorder. British Journal of Psychiatry. https://doi.org/10.1192/bjp.2021.45 CrossRef

Jeffreys, H. (1998). The theory of probability (3rd ed.).

Johnson, L. N., & Baldwin, S. A. (2020). An introduction and illustration of Bayesian modeling in couple and family therapy research. Journal of Marital and Family Therapy, 46(4), 620–637. https://doi.org/10.1111/jmft.12461 CrossRefPubMed

Kass, R. E., & Raftery, A. E. (1995). Bayes factors. Journal of the American Statistical Association, 90(430), 773–795. https://doi.org/10.2307/2291091 CrossRef

Keshavan, M. S., Vinogradov, S., Rumsey, J., Sherrill, J., & Wagner, A. (2014). Cognitive training in mental disorders: Update and future directions. American Journal of Psychiatry, 171(5), 510–522. https://doi.org/10.1176/appi.ajp.2013.13081075 CrossRefPubMed

Kruschke, J. K., & Liddell, T. M. (2018). The Bayesian new statistics: Hypothesis testing, estimation, meta-analysis, and power analysis from a Bayesian perspective. Psychonomic Bulletin & Review, 25(1), 178–206. https://doi.org/10.3758/s13423-016-1221-4 CrossRef

Lavine, M., & Schervish, M. J. (1999). Bayes factors: What they are and what they are not. The American Statistician, 53(2), 119–122. https://doi.org/10.2307/2685729 CrossRef

Nalborczyk, L., Batailler, C., Lœvenbruck, H., Vilain, A., & Bürkner, P.-C. (2019). An introduction to Bayesian multilevel models using brms: A case study of gender effects on vowel variability in standard Indonesian. Journal of Speech, Language, and Hearing Research, 62(5), 1225–1242. https://doi.org/10.1044/2018_JSLHR-S-18-0006 CrossRefPubMed

OCCWG. (2003). Psychometric validation of the obsessive beliefs questionnaire and the interpretation of intrusions inventory: Part I. Behaviour Research and Therapy, 41(8), 863–878. https://doi.org/10.1016/S0005-7967(02)00099-2 CrossRef

Olley, A., Malhi, G., & Sachdev, P. (2007). Memory and executive functioning in obsessive-compulsive disorder: A selective review. Journal of Affective Disorders, 104(1–3), 15–23. https://doi.org/10.1016/j.jad.2007.02.023 CrossRefPubMed

Osterrieth, P. A. (1944). Le test de copie d’une figure complexe; contribution à l’étude de la perception et de la mémoire. [Test of copying a complex figure; contribution to the study of perception and memory.]. Archives De Psychologie, 30, 206–356.

Price, R. B., Gillan, C. M., Hanlon, C., Ferrarelli, F., Kim, T., Karim, H. T., & Ahmari, S. E. (2021). Effect of experimental manipulation of the orbitofrontal cortex on short-term markers of compulsive behavior: A theta burst stimulation study. American Journal of Psychiatry, 178(5), 459–468. https://doi.org/10.1176/appi.ajp.2020.20060821 CrossRefPubMed

R Core Team. (2021). R: A language and environment for statistical computing. R Foundation for Statistical Computing. URL: https://www.R-project.org/.

Rey, A. (1941). L’examen psychologique dans les cas d’encéphalopathie traumatique. (Les problems.). [The psychological examination in cases of traumatic encepholopathy. Problems.]. Archives De Psychologie, 28, 215–285.

Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012). Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry. Trends in Cognitive Sciences, 16(1), 81–91. https://doi.org/10.1016/j.tics.2011.11.009 CrossRefPubMed

Rouder, J. N., Speckman, P. L., Sun, D., Morey, R. D., & Iverson, G. (2009). Bayesian t tests for accepting and rejecting the null hypothesis. Psychonomic Bulletin & Review, 16(2), 225–237. https://doi.org/10.3758/PBR.16.2.225 CrossRef

Ruscio, A. M., Stein, D. J., Chiu, W. T., & Kessler, R. C. (2010). The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Molecular Psychiatry, 15(1), 53–63. https://doi.org/10.1038/mp.2008.94 CrossRefPubMed

Savage, C. R., Baer, L., Keuthen, N. J., Brown, H. D., Rauch, S. L., & Jenike, M. A. (1999). Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder. Biological Psychiatry, 45(7), 905–916. https://doi.org/10.1016/S0006-3223(98)00278-9 CrossRefPubMed

Seow, T. X. F., Benoit, E., Dempsey, C., Jennings, M., Maxwell, A., McDonough, M., & Gillan, C. M. (2020). A dimensional investigation of error-related negativity (ERN) and self-reported psychiatric symptoms. International Journal of Psychophysiology, 158, 340–348. https://doi.org/10.1016/j.ijpsycho.2020.09.019 CrossRefPubMedPubMedCentral

Seow, T. X. F., Benoit, E., Dempsey, C., Jennings, M., Maxwell, A., O’Connell, R., & Gillan, C. M. (2021). Model-based planning deficits in compulsivity are linked to faulty neural representations of task structure. Journal of Neuroscience, 41(30), 6539–6550. https://doi.org/10.1523/jneurosci.0031-21.2021 CrossRefPubMed

Shahar, N., Hauser, T. U., Moutoussis, M., Moran, R., Keramati, M., NSPN consortium, & Dolan, R. J. (2019). Improving the reliability of model-based decision-making estimates in the two-stage decision task with reaction-times and drift-diffusion modeling. PLOS Computational Biology, 15(2), e1006803. https://doi.org/10.1371/journal.pcbi.1006803

Sharp, P. B., Dolan, R. J., & Eldar, E. (2021). Disrupted state transition learning as a computational marker of compulsivity. Psychological Medicine. https://doi.org/10.1017/s0033291721003846 CrossRefPubMedPubMedCentral

Spielberger, C. D. (1983). Manual for the State-Trait Anxiety Inventory STAI (Form Y). Mind Garden.

Stroop, J. R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18(6), 643–662. https://doi.org/10.1037/h0054651 CrossRef

Taylor, S., Zvolensky, M. J., Cox, B. J., Deacon, B., Heimberg, R. G., Ledley, D. R., & Cardenas, S. J. (2007). Robust dimensions of anxiety sensitivity: Development and initial validation of the Anxiety Sensitivity Index-3. Psychological Assessment, 19(2), 176–188. https://doi.org/10.1037/1040-3590.19.2.176 CrossRefPubMed

van Buuren, S., & Groothuis-Oudshoorn, K. (2011). mice: Multivariate imputation by chained equations in R. Journal of Statistical Software, 45(3), 1–67. CrossRef

van der Straten, A., van Leeuwen, W., Denys, D., van Marle, H., & van Wingen, G. (2020). The effect of distress on the balance between goal-directed and habit networks in obsessive-compulsive disorder. Translational Psychiatry, 10(1), 73. https://doi.org/10.1038/s41398-020-0744-7 CrossRefPubMedPubMedCentral

Wagenmakers, E. J., Love, J., Marsman, M., Jamil, T., Ly, A., Verhagen, J., Selker, R., Gronau, Q. F., Dropmann, D., Boutin, B., & Meerhoff, F. (2018). Bayesian inference for psychology. Part II: Example applications with JASP. Psychonomic Bulletin & Review, 25(1), 58–76. https://doi.org/10.3758/s13423-017-1323-7 CrossRef

Wheaton, M. G., Gillan, C. M., & Simpson, H. B. (2019). Does cognitive-behavioral therapy affect goal-directed planning in obsessive-compulsive disorder? Psychiatry Research, 273, 94–99. https://doi.org/10.1016/j.psychres.2018.12.079 CrossRefPubMed

Zainal, N. H., & Newman, M. G. (2018). Worry amplifies theory-of-mind reasoning for negatively valenced social stimuli in generalized anxiety disorder. Journal of Affective Disorders, 227, 824–833. https://doi.org/10.1016/j.jad.2017.11.084 CrossRefPubMed

Zondervan-Zwijnenburg, M., Peeters, M., Depaoli, S., & Van de Schoot, R. (2017). Where do priors come from? Applying guidelines to construct informative priors in small sample research. Research in Human Development, 14(4), 305–320. https://doi.org/10.1080/15427609.2017.1370966 CrossRef

Titel: Goal-Directed Learning Deficits in Patients with OCD: A Bayesian Analysis
Auteurs: Nur Hani Zainal
Joan A. Camprodon
Jennifer L. Greenberg
Aura M. Hurtado
Joshua E. Curtiss
Rebecca Matilde Berger-Gutierrez
Claire M. Gillan
Sabine Wilhelm
Publicatiedatum: 13-01-2023
Uitgeverij: Springer US
Gepubliceerd in: Cognitive Therapy and Research / Uitgave 2/2023
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI: https://doi.org/10.1007/s10608-022-10348-3

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Abstract

Introduction

Methods

Results

Conclusions

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