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24-11-2022 | Original Paper

Efficacy of Sulforaphane in Treatment of Children with Autism Spectrum Disorder: A Randomized Double-Blind Placebo-Controlled Multi-center Trial

Auteurs: Jianjun Ou, Robert C. Smith, Russell H. Tobe, Jingjing Lin, Jen Arriaza, Jed W. Fahey, Ruiting Liu, Ying Zeng, Yanan Liu, Lian Huang, Yidong Shen, Yamin Li, Daomeng Cheng, Brian Cornblatt, John M. Davis, Jingping Zhao, Renrong Wu, Hua Jin

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2024

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Abstract

Sulforaphane has been reported to possibly improve core symptoms associated with autism spectrum disorders from mostly small size studies. Here we present results of a larger randomized clinical trial (N = 108) in China. There were no significant changes in caregiver rated scales between sulforaphane and placebo groups. However, clinician rated scales showed a significant improvement in the sulforaphane group, and one third of participants showed at least a 30% decrease in score by 12 weeks treatment. The effects of sulforaphane were seen across the full range of intelligence and greater in participants over 10 years. Sulforaphane was safe and well-tolerated even for young children. The inconsistent results between caregiver and clinician rated scales suggest more clinical trials are needed to confirm our findings.
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Metagegevens
Titel
Efficacy of Sulforaphane in Treatment of Children with Autism Spectrum Disorder: A Randomized Double-Blind Placebo-Controlled Multi-center Trial
Auteurs
Jianjun Ou
Robert C. Smith
Russell H. Tobe
Jingjing Lin
Jen Arriaza
Jed W. Fahey
Ruiting Liu
Ying Zeng
Yanan Liu
Lian Huang
Yidong Shen
Yamin Li
Daomeng Cheng
Brian Cornblatt
John M. Davis
Jingping Zhao
Renrong Wu
Hua Jin
Publicatiedatum
24-11-2022
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2024
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-022-05784-9