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Quality of Life Research
Gepubliceerd in: Quality of Life Research 1/2018

22-08-2017

Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus: a structural equation modeling approach

Auteurs: Jeong-Won Lee, Ji-Hyoun Kang, Kyung-Eun Lee, Dong-Jin Park, Seong Wook Kang, Seung-Ki Kwok, Seong-Kyu Kim, Jung-Yoon Choe, Hyoun-Ah Kim, Yoon-Kyoung Sung, Kichul Shin, Sang-Il Lee, Chang Hoon Lee, Sung Jae Choi, Shin-Seok Lee

Gepubliceerd in: Quality of Life Research | Uitgave 1/2018

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Abstract

Purpose

This study assessed the relationships among the risk factors for and components of metabolic syndrome (MetS) and health-related quality of life (HRQOL) in a hypothesized causal model using structural equation modeling (SEM) in patients with systemic lupus erythematosus (SLE).

Methods

Of the 505 SLE patients enrolled in the Korean Lupus Network (KORNET registry), 244 had sufficient data to assess the components of MetS at enrollment. Education level, monthly income, corticosteroid dose, Systemic Lupus Erythematosus Disease Activity Index, Physicians’ Global Assessment, Beck Depression Inventory, MetS components, and the Short Form-36 at the time of cohort entry were determined. SEM was used to test the causal relationship based on the Analysis of Moment Structure.

Results

The average age of the 244 patients was 40.7 ± 11.8 years. The SEM results supported the good fit of the model (χ 2 = 71.629, p = 0.078, RMSEA 0.034, CFI 0.972). The final model showed a direct negative effect of higher socioeconomic status and a positive indirect effect of higher disease activity on MetS, the latter through corticosteroid dose. MetS did not directly impact HRQOL but had an indirect negative impact on it, through depression.

Conclusions

In our causal model, MetS risk factors were related to MetS components. The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients.
vorige artikel Prevalence of patient-reported gastrointestinal symptoms and agreement with clinician toxicity assessments in radiation therapy for anal cancer
volgende artikel Health-related quality of life and its determinants in patients with metastatic renal cell carcinoma
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Metagegevens
Titel
Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus: a structural equation modeling approach
Auteurs
Jeong-Won Lee
Ji-Hyoun Kang
Kyung-Eun Lee
Dong-Jin Park
Seong Wook Kang
Seung-Ki Kwok
Seong-Kyu Kim
Jung-Yoon Choe
Hyoun-Ah Kim
Yoon-Kyoung Sung
Kichul Shin
Sang-Il Lee
Chang Hoon Lee
Sung Jae Choi
Shin-Seok Lee
Publicatiedatum
22-08-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2018
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1689-z

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