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Gepubliceerd in:

08-09-2017

Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease

Auteurs: James W. Varni, Robert J. Shulman, Mariella M. Self, Shehzad A. Saeed, George M. Zacur, Ashish S. Patel, Samuel Nurko, Deborah A. Neigut, James P. Franciosi, Miguel Saps, Jolanda M. Denham, Chelsea Vaughan Dark, Cristiane B. Bendo, John F. Pohl, On Behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium

Gepubliceerd in: Quality of Life Research | Uitgave 1/2018

Abstract

Objectives

The primary objective was to investigate the mediating effects of patient-perceived medication adherence barriers in the relationship between gastrointestinal symptoms and generic health-related quality of life (HRQOL) in adolescents with inflammatory bowel disease (IBD). The secondary objective explored patient health communication and gastrointestinal worry as additional mediators with medication adherence barriers in a serial multiple mediator model.

Methods

The Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms, Medicines, Communication, Gastrointestinal Worry, and Generic Core Scales were completed in a 9-site study by 172 adolescents with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, constipation, or diarrhea and perceived medication adherence barriers were tested for bivariate and multivariate linear associations with HRQOL. Mediational analyses were conducted to test the hypothesized mediating effects of perceived medication adherence barriers as an intervening variable between gastrointestinal symptoms and HRQOL.

Results

The predictive effects of gastrointestinal symptoms on HRQOL were mediated in part by perceived medication adherence barriers. Patient health communication was a significant additional mediator. In predictive analytics models utilizing multiple regression analyses, demographic variables, gastrointestinal symptoms (stomach pain, constipation, or diarrhea), and perceived medication adherence barriers significantly accounted for 45, 38, and 29 percent of the variance in HRQOL (all Ps < 0.001), respectively, demonstrating large effect sizes.

Conclusions

Perceived medication adherence barriers explain in part the effects of gastrointestinal symptoms on HRQOL in adolescents with IBD. Patient health communication to healthcare providers and significant others further explain the mechanism in the relationship between gastrointestinal symptoms, perceived medication adherence barriers, and HRQOL.

vorige artikel The roles of physical activity and sedentary behavior on Hispanic children’s mental health: a motor skill perspective

volgende artikel Physical activity and health-related quality of life among schoolchildren from disadvantaged neighbourhoods in Port Elizabeth, South Africa

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Titel: Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease
Auteurs: James W. Varni
Robert J. Shulman
Mariella M. Self
Shehzad A. Saeed
George M. Zacur
Ashish S. Patel
Samuel Nurko
Deborah A. Neigut
James P. Franciosi
Miguel Saps
Jolanda M. Denham
Chelsea Vaughan Dark
Cristiane B. Bendo
John F. Pohl
On Behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium
Publicatiedatum: 08-09-2017
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 1/2018
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-017-1702-6

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Abstract

Objectives

Methods

Results

Conclusions

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