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11-02-2017

Depressive symptoms moderate the relationship between medication regimen complexity and objectively measured medication adherence in adults with heart failure

Auteurs: Carly M. Goldstein, Emily C. Gathright, John Gunstad, Mary A. Dolansky, Joseph D. Redle, Richard Josephson, Shirley M. Moore, Joel W. Hughes

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 4/2017

Abstract

Patients with heart failure (HF) take many medications to manage their HF and comorbidities, and 20–50% experience depression. Depressed individuals with more complex medication regimens may be at greater risk for poor adherence. The aim of this study was to assess depressive symptoms as a moderator of the relationship between medication regimen complexity and medication adherence in an observational study of patients with HF. In hierarchical linear regression with the final sample of 299, the interaction of medication regimen complexity and depressive symptoms predicted medication adherence, p < .05. For individuals with higher levels of depressive symptoms [1 standard deviation (SD) above the mean], more regimen complexity was associated with lower adherence. For individuals with low (1 SD below the mean) or average levels of depressive symptoms, regimen complexity was unrelated to medication adherence. Care management strategies, including pillboxes and caregiver involvement, may be valuable in HF patients with depression.

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Titel: Depressive symptoms moderate the relationship between medication regimen complexity and objectively measured medication adherence in adults with heart failure
Auteurs: Carly M. Goldstein
Emily C. Gathright
John Gunstad
Mary A. Dolansky
Joseph D. Redle
Richard Josephson
Shirley M. Moore
Joel W. Hughes
Publicatiedatum: 11-02-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 4/2017
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-017-9829-z

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