Skip to main content
Top
Gepubliceerd in: Neuropraxis 6/2010

01-12-2010

De rol van testosteron en oxytocine in menselijke sociale interactie

Auteurs: Drs. Peter Bos, dr. Jack van Honk

Gepubliceerd in: Neuropraxis | Uitgave 6/2010

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

Dat hormonen invloed hebben op menselijk sociaal gedrag lijdt voor de meeste mensen geen twijfel. Een zwangere vrouw die haar emoties niet meer onder controle heeft, krijgt te horen dat het haar ‘hormonen’ zijn. Jongens die agressief zijn of risico nemen om indruk te maken op anderen krijgen het label ‘te veel testosteron’ opgeplakt. Binnen de wetenschap wordt de hormonale regulatie van sociaal gedrag bij mensen echter niet als vanzelfsprekend aangenomen. Terwijl het gedrag van knaagdieren gezien wordt als zijnde sterk onder de invloed van hormonen, heerst er onder wetenschappers veelal de opinie dat het gedrag van mensen ‘geëmancipeerd’ is van hormonale controle (Keverne, Martel, & Nevison, 1996). De evolutionair recente expansie van de neocortex bij primaten zou hiertoe geleid hebben. Top-down controle van de neocortex over de dieper gelegen, primitievere hersengebieden die sterk onder hormonale controle staan, zou de effecten van hormonen uitvlakken. Binnen deze visie spelen hormonen geen rol van betekenis bij menselijk sociaal gedrag. In het afgelopen decennium zijn er echter tientallen studies verschenen die deze stellingname in twijfel trekken. Er is met name veel bekend geworden over de effecten van het seksespecifieke hormoon testosteron, en van een neuropeptide dat een belangrijke rol speelt bij de bevalling en borstvoeding: oxytocine. In dit artikel beschrijven we kort wat er bekend is over de rol van deze hormonen in het sociaal gedrag bij dieren. Vervolgens gaan we in op de rol van testosteron en oxytocine bij interpersoonlijk vertrouwen, als voorbeeld van een lijn van onderzoek naar de endocrinologie van menselijk sociaal gedrag. Als laatste bespreken we kort de mogelijke klinische relevantie van dit onderzoeksgebied.
Literatuur
go back to reference Acher, R. (1980). Molecular evolution of biologically active polypeptides. Proceedings of the Royal Society B: Biological Sciences, 210, 1178, 21–43.CrossRef Acher, R. (1980). Molecular evolution of biologically active polypeptides. Proceedings of the Royal Society B: Biological Sciences, 210, 1178, 21–43.CrossRef
go back to reference Adolphs, R., Tranel, D. & Damasio, A. R. (1998). The human amygdala in social judgment. Nature, 393, 6684, 470–474.PubMedCrossRef Adolphs, R., Tranel, D. & Damasio, A. R. (1998). The human amygdala in social judgment. Nature, 393, 6684, 470–474.PubMedCrossRef
go back to reference Andari, E., Duhamel, J.R., Zalla, T., Herbrecht, E., Leboyer, M. & Sirigu, A. (2010). Promoting social behavior with oxytocin in highfunctioning autism spectrum disorders. Proceedings of the National Acadamy of Sciences of the U.S.A., 107,9, 4389–4394.CrossRef Andari, E., Duhamel, J.R., Zalla, T., Herbrecht, E., Leboyer, M. & Sirigu, A. (2010). Promoting social behavior with oxytocin in highfunctioning autism spectrum disorders. Proceedings of the National Acadamy of Sciences of the U.S.A., 107,9, 4389–4394.CrossRef
go back to reference Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U. & Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron, 58,4, 639–650.PubMedCrossRef Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U. & Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron, 58,4, 639–650.PubMedCrossRef
go back to reference Born, J., Lange, T., Kern, W., McGregor, G.P., Bickel, U. & Fehm, H.L. (2002). Sniffing neuropeptides: a transnasal approach to the human brain. Nature Neuroscience, 5,6, 514–516.PubMedCrossRef Born, J., Lange, T., Kern, W., McGregor, G.P., Bickel, U. & Fehm, H.L. (2002). Sniffing neuropeptides: a transnasal approach to the human brain. Nature Neuroscience, 5,6, 514–516.PubMedCrossRef
go back to reference Bos, P.A., Terburg, D. & van Honk, J. (2010). Testosterone decreases trust in socially naive humans. Proceedings of the National Acadamy of Sciences of the U.S.A., 107,22, 9991–9995.CrossRef Bos, P.A., Terburg, D. & van Honk, J. (2010). Testosterone decreases trust in socially naive humans. Proceedings of the National Acadamy of Sciences of the U.S.A., 107,22, 9991–9995.CrossRef
go back to reference Campbell, A. (2008). Attachment, aggression and affiliation: The role of oxytocin in female social behavior. Biological Psychology, 77,1, 1–10.PubMedCrossRef Campbell, A. (2008). Attachment, aggression and affiliation: The role of oxytocin in female social behavior. Biological Psychology, 77,1, 1–10.PubMedCrossRef
go back to reference Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23,8, 779–818.PubMedCrossRef Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23,8, 779–818.PubMedCrossRef
go back to reference Davis, M. & Whalen, P. J. (2001). The amygdala: vigilance and emotion. Molecular Psychiatry, 6,1, 13–34.PubMedCrossRef Davis, M. & Whalen, P. J. (2001). The amygdala: vigilance and emotion. Molecular Psychiatry, 6,1, 13–34.PubMedCrossRef
go back to reference Goodson, J.L., & Bass, A. H. (2001). Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates. Brain Research Reviews, 35,3, 246–265.PubMedCrossRef Goodson, J.L., & Bass, A. H. (2001). Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates. Brain Research Reviews, 35,3, 246–265.PubMedCrossRef
go back to reference Guastella, A.J., Einfeld, S.L., Gray, K.M., Rinehart, N.J., Tonge, B.J., Lambert, T.J. et al. (2009). Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders. Biological Psychiatry, 76,7, 692–694. Guastella, A.J., Einfeld, S.L., Gray, K.M., Rinehart, N.J., Tonge, B.J., Lambert, T.J. et al. (2009). Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders. Biological Psychiatry, 76,7, 692–694.
go back to reference Guastella, A.J., Howard, A L., Dadds, M R., Mitchell, P, & Carson, D.S. (2009). A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology, 34,6, 917–923.PubMedCrossRef Guastella, A.J., Howard, A L., Dadds, M R., Mitchell, P, & Carson, D.S. (2009). A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology, 34,6, 917–923.PubMedCrossRef
go back to reference Hermans, E.J., Ramsey, N. F. & van Honk, J. (2008). Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans. Biological Psychiatry, 63,3, 263–270.PubMedCrossRef Hermans, E.J., Ramsey, N. F. & van Honk, J. (2008). Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans. Biological Psychiatry, 63,3, 263–270.PubMedCrossRef
go back to reference Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C.M., Aronowitz, B.R., et al. (2003). Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger’s disorders. Neuropsychopharmacology, 28,1, 193–198.PubMedCrossRef Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C.M., Aronowitz, B.R., et al. (2003). Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger’s disorders. Neuropsychopharmacology, 28,1, 193–198.PubMedCrossRef
go back to reference Johnson, R.T, & Breedlove, S. M. (2010). Human trust: Testosterone raises suspicion. Proceedings of the National Acadamy of Sciences of the U.S.A., 107,25, 11149–11150.CrossRef Johnson, R.T, & Breedlove, S. M. (2010). Human trust: Testosterone raises suspicion. Proceedings of the National Acadamy of Sciences of the U.S.A., 107,25, 11149–11150.CrossRef
go back to reference Keverne, E.B., Martel, F.L. & Nevison, C.M. (1996). Primate brain evolution: genetic and functional considerations. Proceedings of the Royal Society B: Biological Sciences, 263,1371, 689–696.PubMedCrossRef Keverne, E.B., Martel, F.L. & Nevison, C.M. (1996). Primate brain evolution: genetic and functional considerations. Proceedings of the Royal Society B: Biological Sciences, 263,1371, 689–696.PubMedCrossRef
go back to reference Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25,49, 11489–11493.PubMedCrossRef Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25,49, 11489–11493.PubMedCrossRef
go back to reference Kosfeld, M., Heinrichs, M., Zak, P.J., Fischbacher, U. & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435,7042, 673–676.PubMedCrossRef Kosfeld, M., Heinrichs, M., Zak, P.J., Fischbacher, U. & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435,7042, 673–676.PubMedCrossRef
go back to reference Landgraf, R. & Neumann, I.D. (2004). Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Frontiers in Neuroendocrinology, 25,3–4, 150–176.PubMedCrossRef Landgraf, R. & Neumann, I.D. (2004). Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Frontiers in Neuroendocrinology, 25,3–4, 150–176.PubMedCrossRef
go back to reference Nelson, R.J. & Trainor, B.C. (2007). Neural mechanisms of aggression. Nature Reviews Neuroscience, 8,7, 536–546.PubMedCrossRef Nelson, R.J. & Trainor, B.C. (2007). Neural mechanisms of aggression. Nature Reviews Neuroscience, 8,7, 536–546.PubMedCrossRef
go back to reference Tuiten, A., Van Honk, J., Koppeschaar, H., Bernaards, C., Thijssen, J. & Verbaten, R. (2000). Time course of effects of testosterone administration on sexual arousal in women. Archives of General Psychiatry, 57,2, 149–153; discussion 155-146.PubMedCrossRef Tuiten, A., Van Honk, J., Koppeschaar, H., Bernaards, C., Thijssen, J. & Verbaten, R. (2000). Time course of effects of testosterone administration on sexual arousal in women. Archives of General Psychiatry, 57,2, 149–153; discussion 155-146.PubMedCrossRef
go back to reference Wingfield, J.C., Hegner, R.E., Dufty, J., Alfred M. & Ball, G.F. (1990). The ‘Challenge Hypothesis’: Theoretical Implications for Patterns of Testosterone Secretion, Mating Systems, and Breeding Strategies. The American Naturalist, 136,6, 829.CrossRef Wingfield, J.C., Hegner, R.E., Dufty, J., Alfred M. & Ball, G.F. (1990). The ‘Challenge Hypothesis’: Theoretical Implications for Patterns of Testosterone Secretion, Mating Systems, and Breeding Strategies. The American Naturalist, 136,6, 829.CrossRef
go back to reference Winston, J.S., Strange, B.A., O’Doherty, J. & Dolan, R.J. (2002). Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nature Neuroscience, 5,3, 277–283.PubMedCrossRef Winston, J.S., Strange, B.A., O’Doherty, J. & Dolan, R.J. (2002). Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nature Neuroscience, 5,3, 277–283.PubMedCrossRef
Metagegevens
Titel
De rol van testosteron en oxytocine in menselijke sociale interactie
Auteurs
Drs. Peter Bos
dr. Jack van Honk
Publicatiedatum
01-12-2010
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 6/2010
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-010-0815-2

Andere artikelen Uitgave 6/2010

Neuropraxis 6/2010 Naar de uitgave

EditorialNotes

Woorden Vooraf

OriginalPaper

Signalement