Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease
- 31-10-2019
Gepubliceerd in:
- Auteurs
- Cristina Esquinas
- Maria A. Ramon
- Alexa Nuñez
- Jesús Molina
- José A. Quintano
- Miguel Roman-Rodríguez
- Karlos Naberan
- Carl Llor
- Carlos Roncero
- Marc Miravitlles
- Miriam Barrecheguren
- Gepubliceerd in
- Quality of Life Research | Uitgave 3/2020
Abstract
Purpose
Impaired health-related quality of life (HRQoL) is associated with poor health outcomes in chronic obstructive pulmonary disease (COPD). The aim of this study was to determine health utilities in patients with COPD and to identify the variables with the greatest impact.
Methods
This is a pooled analysis of data from 4 observational studies performed in stable COPD patients. Evaluation of patient HRQoL utilities was performed using the Spanish version of the self-administered EuroQoL 5 Dimensions (EQ-5D) questionnaire. EQ-5D utilities were described and compared according to several markers of disease severity.
Results
6198 patients reported a mean (SD) EQ-5D index of 0.67 (0.26). A linear dose response relationship between EQ-5D utility and modified Medical Research Council (mMRC) score, forced expiratory volume in one 1 s (% predicted), COPD hospital admissions in the previous year, self-reported daily walking time, Charlson index, body mass index, obstruction, dyspnoea and exacerbation (BODEx) index, COPD assessment test (CAT), hospital anxiety and depression scale was observed (p for trend < 0.001). In multivariate analysis, patients reporting lower utility values were those with more dyspnoea, more comorbidities, using long-term oxygen therapy, with previous hospitalisations due to a COPD exacerbation and higher (worse) CAT score.
Conclusion
HRQoL measures such as EQ-5D can assist clinicians to understand the impact of respiratory disease on COPD patients.
- Titel
- Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease
- Auteurs
-
Cristina Esquinas
Maria A. Ramon
Alexa Nuñez
Jesús Molina
José A. Quintano
Miguel Roman-Rodríguez
Karlos Naberan
Carl Llor
Carlos Roncero
Marc Miravitlles
Miriam Barrecheguren
- Publicatiedatum
- 31-10-2019
- Uitgeverij
- Springer International Publishing
- Gepubliceerd in
-
Quality of Life Research / Uitgave 3/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649 - DOI
- https://doi.org/10.1007/s11136-019-02340-4
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