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Gepubliceerd in: Neuropraxis 2/2003

01-04-2003 | Artikelen

Cognitieve functies van kinderen behandeld voor kanker

Auteurs: dr. Annet Kingma, drs. Nathalie Jansen

Gepubliceerd in: Neuropraxis | Uitgave 2/2003

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semenvatting

Van kinderen in de leeftijd tot 16 jaar die kanker hebben, overleeft tegenwoordig 70% de ziekte. Volgens schattingen heeft in de westerse wereld in het jaar 2010 één op de 250 volwassenen als kind kanker gehad. De vraag is nu of de biologische genezing ook gepaard gaat met een ongestoorde mentale ontwikkeling en goede kwaliteit van leven. Als de ziekte gelokaliseerd is in, of wanneer de behandeling aangrijpt op het centraal zenuwstelsel bestaat de kans op een verslechterd cognitief functioneren.
In dit artikel worden met name de potentiële, blijvende neuropsychologische gevolgen van een behandeling voor leukemie of een hersentumor besproken. Ruim de helft van de kinderen met kanker lijdt aan leukemie of heeft een hersentumor. Aan de orde komen zowel de literatuur als eigen onderzoek. Daarnaast bespreken we de mogelijke gevolgen van de verkregen cognitieve schade voor de schoolloopbaan en geven we richtlijnen voor de praktijk als de vraag wordt gesteld of leerproblemen in verband staan met de doorgemaakte behandeling.
Literatuur
go back to reference Aarnoudse C.C. & Kingma A. (2002). Neuropsychological impairment in children with brain tumors: a prospective longitidinal study with pre-operative evaluation. Journal of Medical Pediatric Oncology 4, 347. Aarnoudse C.C. & Kingma A. (2002). Neuropsychological impairment in children with brain tumors: a prospective longitidinal study with pre-operative evaluation. Journal of Medical Pediatric Oncology 4, 347.
go back to reference Bakke S.J., Fossen A., Storm-Mathiesen J. e.a. (1993). Long-term cerebral effects of cns chemotherapy in children with acute lymphoblastic leukemia. American Journal of Pediatric Hematology/Oncology 267-270. Bakke S.J., Fossen A., Storm-Mathiesen J. e.a. (1993). Long-term cerebral effects of cns chemotherapy in children with acute lymphoblastic leukemia. American Journal of Pediatric Hematology/Oncology 267-270.
go back to reference Bleyer W.A. (1998). Chemo- radiotherapy Interaction in the Central Nervous System. Medical and Pediatric Oncology Suppl. 1, 10-16. Bleyer W.A. (1998). Chemo- radiotherapy Interaction in the Central Nervous System. Medical and Pediatric Oncology Suppl. 1, 10-16.
go back to reference Brown R.T., Madan-Swain A., Walco G.A. e.a. (1998). Cognitive and academic late effects among children previously treated for acute lymphocytic leukemia receiving chemotherapy as cns prophylaxis. Journal Pediatric Psycholology 5, 333-340. Brown R.T., Madan-Swain A., Walco G.A. e.a. (1998). Cognitive and academic late effects among children previously treated for acute lymphocytic leukemia receiving chemotherapy as cns prophylaxis. Journal Pediatric Psycholology 5, 333-340.
go back to reference Butler R.W. & Copeland D.R. (1993). Neuropsychological effects of central nervous system prophylactic treatment in childhood leukemia: methodological considerations. Journal Pediatric Psycholology 3, 319-338. Butler R.W. & Copeland D.R. (1993). Neuropsychological effects of central nervous system prophylactic treatment in childhood leukemia: methodological considerations. Journal Pediatric Psycholology 3, 319-338.
go back to reference Carroll P.V., Christ E.R., Bengtsson B.A. e.a. (1998). Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. Journal of Clinical Endocrinology and Metabolism 2, 382-395. Carroll P.V., Christ E.R., Bengtsson B.A. e.a. (1998). Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. Journal of Clinical Endocrinology and Metabolism 2, 382-395.
go back to reference Copeland D.R., Moore B.D., Francis D.J. e.a. (1996). Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. Journal of Clinical Oncology 10, 2826-2835. Copeland D.R., Moore B.D., Francis D.J. e.a. (1996). Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. Journal of Clinical Oncology 10, 2826-2835.
go back to reference Cousens P. (1997). Specific learning problems among children treated for acute lymphoblastic leukemia. International Journal of Pediatric Hematology/Oncology 353-362. Cousens P. (1997). Specific learning problems among children treated for acute lymphoblastic leukemia. International Journal of Pediatric Hematology/Oncology 353-362.
go back to reference Dennis M., Hetherington C.R., Spiegler B.J. (1998). Memory and attention after childhood brain tumors. Journal of Medical Pediatric Oncology Suppl.1, 25-33. Dennis M., Hetherington C.R., Spiegler B.J. (1998). Memory and attention after childhood brain tumors. Journal of Medical Pediatric Oncology Suppl.1, 25-33.
go back to reference DiMario F.J. & Packer R.J. (1990). Acute mental status changes in children with systemic cancer. Pediatrics 353-360. DiMario F.J. & Packer R.J. (1990). Acute mental status changes in children with systemic cancer. Pediatrics 353-360.
go back to reference Drigan R., Spirito A., Gelber R.D. (1992). Behavioral effects of corticosteroids in children with all. Journal of Medical Pediatric Oncology 13-21. Drigan R., Spirito A., Gelber R.D. (1992). Behavioral effects of corticosteroids in children with all. Journal of Medical Pediatric Oncology 13-21.
go back to reference Espy K.A., Kaufmann P.M., Glisky M.L. (2001). New procedures to assess executive functions in preschool children. Clininal Neuropsychology 1, 46-58. Espy K.A., Kaufmann P.M., Glisky M.L. (2001). New procedures to assess executive functions in preschool children. Clininal Neuropsychology 1, 46-58.
go back to reference Flynn J.R. (1984). Massive iq gains in 14 nations: what iq tests really measure. Psychological Bulletin 171-191. Flynn J.R. (1984). Massive iq gains in 14 nations: what iq tests really measure. Psychological Bulletin 171-191.
go back to reference Harila-Saari A.H., Paäkko E.L., Vainionpaa L.K. e.a. (1998). A longitudinal magnetic resonance imaging study of the brain in survivors in childhood acute lymphoblastic leukemia. Cancer 12, 2608-2617. Harila-Saari A.H., Paäkko E.L., Vainionpaa L.K. e.a. (1998). A longitudinal magnetic resonance imaging study of the brain in survivors in childhood acute lymphoblastic leukemia. Cancer 12, 2608-2617.
go back to reference Hertzberg H., Huk W.J., Ueberall M.A. e.a. (1997). cns late effects after all therapy in childhood. Part I: Neuroradiological findings in long-term survivors of childhood all ’ an evaluation of the interferences between morphology and neuropsychological performance. The German Late Effects Working Group. Journal of Medical Pediatric Oncology 6, 387-400. Hertzberg H., Huk W.J., Ueberall M.A. e.a. (1997). cns late effects after all therapy in childhood. Part I: Neuroradiological findings in long-term survivors of childhood all ’ an evaluation of the interferences between morphology and neuropsychological performance. The German Late Effects Working Group. Journal of Medical Pediatric Oncology 6, 387-400.
go back to reference Hill D.E., Ciesielski K.T., Sethre-Hofstad L. e.a. (1997). Visual and verbal short-term memory deficits in childhood leukemia survivors after intrathecal chemotherapy. Journal Pediatric Psychology 6, 861-870. Hill D.E., Ciesielski K.T., Sethre-Hofstad L. e.a. (1997). Visual and verbal short-term memory deficits in childhood leukemia survivors after intrathecal chemotherapy. Journal Pediatric Psychology 6, 861-870.
go back to reference Hopewell J.W. (1998). Radiation injury to the central nervous system. Medical and Pediatric Oncology Suppl. 1, 1-9. Hopewell J.W. (1998). Radiation injury to the central nervous system. Medical and Pediatric Oncology Suppl. 1, 1-9.
go back to reference Jankovic M., Brouwers P., Valsecchi M.G. e.a. (1994). Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. Lancet 224-227. Jankovic M., Brouwers P., Valsecchi M.G. e.a. (1994). Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. Lancet 224-227.
go back to reference Jansen N.C.A.J., Kingma A., Tellegen P.J. e.a. (2002). Neuropsychologic assessment of newly diagnosed children with acute lymphoblastic leukemia (ALL) and their siblings during early hospitalisation. Journal of Medical Pediatric Oncology 4, 346. Jansen N.C.A.J., Kingma A., Tellegen P.J. e.a. (2002). Neuropsychologic assessment of newly diagnosed children with acute lymphoblastic leukemia (ALL) and their siblings during early hospitalisation. Journal of Medical Pediatric Oncology 4, 346.
go back to reference Kaleita T.A., Reaman G.H., MacLean W.E. e.a. (1999). Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: a Children's Cancer Group report. Cancer 8, 1859-1865. Kaleita T.A., Reaman G.H., MacLean W.E. e.a. (1999). Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: a Children's Cancer Group report. Cancer 8, 1859-1865.
go back to reference Keime-Guibert F., Napolitano M., Delattre J.Y. (1998). Neurological complications of radiotherapy and chemotherapy. Journal of Neurology 11, 695-708. Keime-Guibert F., Napolitano M., Delattre J.Y. (1998). Neurological complications of radiotherapy and chemotherapy. Journal of Neurology 11, 695-708.
go back to reference Kingma A., Assman-Hulsmans C.F.C.H., Mos K. e.a. (1999). Neuropsychologische restverschijnselen na behandeling van een hersentumor op de kinderleeftijd. Tijdschrift voor Kindergeneeskunde 80-86. Kingma A., Assman-Hulsmans C.F.C.H., Mos K. e.a. (1999). Neuropsychologische restverschijnselen na behandeling van een hersentumor op de kinderleeftijd. Tijdschrift voor Kindergeneeskunde 80-86.
go back to reference Kingma A., Mooyaart E.L., Kamps W.A. e.a. (1993). Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age. American Journal of Pediatric Hematology/Oncology 2, 231-238. Kingma A., Mooyaart E.L., Kamps W.A. e.a. (1993). Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age. American Journal of Pediatric Hematology/Oncology 2, 231-238.
go back to reference Kingma A., Rammeloo J.A., Van der Does-van den Berg A. e.a. (2000). Academic career after treatment for acute lymphoblastic leukemia. Archives of Disease in Childhood 5, 353-357. Kingma A., Rammeloo J.A., Van der Does-van den Berg A. e.a. (2000). Academic career after treatment for acute lymphoblastic leukemia. Archives of Disease in Childhood 5, 353-357.
go back to reference Kingma A., Van Dommelen R.I., Mooyaart E.L. e.a. (2001). Slight cognitive impairment and mri abnormalities but normal academic career in children treated for acute lymphoblastic leukemia with chemotherapy only. Journal of Pediatrics 3, 413-420. Kingma A., Van Dommelen R.I., Mooyaart E.L. e.a. (2001). Slight cognitive impairment and mri abnormalities but normal academic career in children treated for acute lymphoblastic leukemia with chemotherapy only. Journal of Pediatrics 3, 413-420.
go back to reference Kingma A., Van Dommelen R.I., Mooyaart E.L. e.a. (2002). No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study. Journal of Pediatric Hematology and Oncology 106-114. Kingma A., Van Dommelen R.I., Mooyaart E.L. e.a. (2002). No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study. Journal of Pediatric Hematology and Oncology 106-114.
go back to reference Lannering B., Marky I., Lundberg A. e.a. (1990). Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life. Journal of Medical Pediatric Oncology 304-310. Lannering B., Marky I., Lundberg A. e.a. (1990). Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life. Journal of Medical Pediatric Oncology 304-310.
go back to reference Lesnik P.G., Ciesielski K.T., Hart B.L. e.a. (1998). Evidence for cerebellar-frontal subsystem changes in children treated with intrathecal chemotherapy for leukemia: enhanced data analysis using an effect size model. Archives of Neurology 12, 1561-1568. Lesnik P.G., Ciesielski K.T., Hart B.L. e.a. (1998). Evidence for cerebellar-frontal subsystem changes in children treated with intrathecal chemotherapy for leukemia: enhanced data analysis using an effect size model. Archives of Neurology 12, 1561-1568.
go back to reference Levisohn L., Cronin-Golomb A., Schmahmann J.D. (2000). Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. Brain (Oxford) 1041-1050. Levisohn L., Cronin-Golomb A., Schmahmann J.D. (2000). Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. Brain (Oxford) 1041-1050.
go back to reference Madan-Swain A. & Brown R.T. (1991). Cognitive and psychosocial sequelae for children with acute lymphoblastic leukemia and their families. Clinical Psychological Review 267-294. Madan-Swain A. & Brown R.T. (1991). Cognitive and psychosocial sequelae for children with acute lymphoblastic leukemia and their families. Clinical Psychological Review 267-294.
go back to reference Moore B.D., Copeland D.R., Ried H. e.a. (1992). Neurophysiological basis of cognitive deficits in long-tyerm survivors of childhood cancer. Archives of Neurology 809-817. Moore B.D., Copeland D.R., Ried H. e.a. (1992). Neurophysiological basis of cognitive deficits in long-tyerm survivors of childhood cancer. Archives of Neurology 809-817.
go back to reference Mulhern R.K., Armstrong F.D., Thompson S.J. (1998). Function-specific neuropsychological assessment. Medical and Pediatric Oncology 34. Mulhern R.K., Armstrong F.D., Thompson S.J. (1998). Function-specific neuropsychological assessment. Medical and Pediatric Oncology 34.
go back to reference Newcomer J.W., Craft S., Hershey T. e.a. (1994). Glucocorticoid-induced Impairment in Declarative Memory Performance in Adult Humans. Journal of Neuroscience 4, 2047-2053. Newcomer J.W., Craft S., Hershey T. e.a. (1994). Glucocorticoid-induced Impairment in Declarative Memory Performance in Adult Humans. Journal of Neuroscience 4, 2047-2053.
go back to reference Paäkko E.L., Harila-Saari A., Vanionpaa L. e.a. (2000). White matter changes on mri during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings (In Process Citation). Journal of Medical Pediatric Oncology 5, 456-461. Paäkko E.L., Harila-Saari A., Vanionpaa L. e.a. (2000). White matter changes on mri during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings (In Process Citation). Journal of Medical Pediatric Oncology 5, 456-461.
go back to reference Palm L., Persson E., Bjerre I. e.a. (1992). Sleep and wakefulness in preadolescent children with deficits in attention, motor control and perception. Acta Paediatrica 8, 618-624. Palm L., Persson E., Bjerre I. e.a. (1992). Sleep and wakefulness in preadolescent children with deficits in attention, motor control and perception. Acta Paediatrica 8, 618-624.
go back to reference Palmer S.L., Foloubeva O., Reddick W.E. e.a. (2001). Patterns of Intellectuel Development Among Survivors of Pediatric Medulloblastoma: A Longitudinal Analysis. Journal of Clinical Oncology 8, 2302-2308. Palmer S.L., Foloubeva O., Reddick W.E. e.a. (2001). Patterns of Intellectuel Development Among Survivors of Pediatric Medulloblastoma: A Longitudinal Analysis. Journal of Clinical Oncology 8, 2302-2308.
go back to reference Pfefferbaum A., Mathalon A., Sullivan E.V. (1994). A quantative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Archives of Neurology 874-887. Pfefferbaum A., Mathalon A., Sullivan E.V. (1994). A quantative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Archives of Neurology 874-887.
go back to reference Postma A., Behrendt H., Groot-Loonen J.J. e.a. (1999). Iatrogene gevolgen van kanker op de kinderleeftijd. Tijdschrift voor Kindergeneeskunde 5, 219-223. Postma A., Behrendt H., Groot-Loonen J.J. e.a. (1999). Iatrogene gevolgen van kanker op de kinderleeftijd. Tijdschrift voor Kindergeneeskunde 5, 219-223.
go back to reference Ris M.D. & Noll R.B. (1994). Long-term neurobehavioral outcome in pediatric braintumor patients: review and methodological critique. Journal of Clinical Experimental Neuropsychology 1, 21-42. Ris M.D. & Noll R.B. (1994). Long-term neurobehavioral outcome in pediatric braintumor patients: review and methodological critique. Journal of Clinical Experimental Neuropsychology 1, 21-42.
go back to reference Ris M.D., Packer R., Goldwein J. e.a. (2001). Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. Journal of Clinical Oncology 15, 3470-3476. Ris M.D., Packer R., Goldwein J. e.a. (2001). Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. Journal of Clinical Oncology 15, 3470-3476.
go back to reference Roman D.D. & Sperduto P.W. (1995). Neuropsychological effects of cranial radiation: current knowledge and future directions. International Journal of Radiatian Oncology Biology Psychology 4, 983-998. Roman D.D. & Sperduto P.W. (1995). Neuropsychological effects of cranial radiation: current knowledge and future directions. International Journal of Radiatian Oncology Biology Psychology 4, 983-998.
go back to reference Rourke B.P. (1987). Syndrome of nonverbal learning disabilities: the final common pathway of white matter disease/dysfunction? Clininal Neuropsychology 209-234. Rourke B.P. (1987). Syndrome of nonverbal learning disabilities: the final common pathway of white matter disease/dysfunction? Clininal Neuropsychology 209-234.
go back to reference Stebhens J.A., Kaleita T.A., Noll R.B. (1991). CNS prophylaxis of childhood leukemia: what are the long term neuropsychological, neurological and behavioral effects? Journal of Neuropsychology 147-177. Stebhens J.A., Kaleita T.A., Noll R.B. (1991). CNS prophylaxis of childhood leukemia: what are the long term neuropsychological, neurological and behavioral effects? Journal of Neuropsychology 147-177.
go back to reference Thoonen G., Roosenboom N., Van Roosmalen T. e.a. (1998). Kinderen met een hersentumor; een terugblik op het schoolverloop. 165-177. Thoonen G., Roosenboom N., Van Roosmalen T. e.a. (1998). Kinderen met een hersentumor; een terugblik op het schoolverloop. 165-177.
go back to reference Ueberall M.A., Wenzel D., Hertzberg H. e.a. (1997). cns Late Effects After all Therapy in Childhood. Part II: Conventional eeg Recordings in Asymptomatic Long-Term Survivors of Childhood all. An Evaluation of the Interferences Between Neurophysiology, Neurology, Psychology, and cns Morphology. Medical and Pediatric Oncology 121-131. Ueberall M.A., Wenzel D., Hertzberg H. e.a. (1997). cns Late Effects After all Therapy in Childhood. Part II: Conventional eeg Recordings in Asymptomatic Long-Term Survivors of Childhood all. An Evaluation of the Interferences Between Neurophysiology, Neurology, Psychology, and cns Morphology. Medical and Pediatric Oncology 121-131.
go back to reference Visser O., Coebergh J.W.W., Schouten L.J. (1994). Incidence of cancer in the Netherlands 1991. Third report of the Netherlands Cancer Registry. Visser O., Coebergh J.W.W., Schouten L.J. (1994). Incidence of cancer in the Netherlands 1991. Third report of the Netherlands Cancer Registry.
go back to reference Waber D.P., Carpentieri S.C., Klar N. e.a. (2000). Cognitive sequelae in children treated for acute lymphoblastic leukemia with dexamethasone or prednisone (see comments). Journal of Pediatric Hematology/Oncology 3, 206-213. Waber D.P., Carpentieri S.C., Klar N. e.a. (2000). Cognitive sequelae in children treated for acute lymphoblastic leukemia with dexamethasone or prednisone (see comments). Journal of Pediatric Hematology/Oncology 3, 206-213.
Metagegevens
Titel
Cognitieve functies van kinderen behandeld voor kanker
Auteurs
dr. Annet Kingma
drs. Nathalie Jansen
Publicatiedatum
01-04-2003
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 2/2003
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/BF03099808

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