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Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2010

01-09-2010 | Brief Report

Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder

Auteurs: Kenneth D. Gadow, Jasmin Roohi, Carla J. DeVincent, Sarah Kirsch, Eli Hatchwell

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2010

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Abstract

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
Literatuur
go back to reference Arnold, P. D., Sicard, T., Burroughs, E., Richter, M. A., & Kennedy, J. L. (2006). Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Archives of General Psychiatry, 63, 769–776. CrossRefPubMed Arnold, P. D., Sicard, T., Burroughs, E., Richter, M. A., & Kennedy, J. L. (2006). Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Archives of General Psychiatry, 63, 769–776. CrossRefPubMed
go back to reference Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes. Molecular Genetics, 14, 746–754. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes. Molecular Genetics, 14, 746–754.
go back to reference Billstedt, E., Gillberg, I. C., & Gillberg, C. (2007). Autism in adult: Symptom patterns and early childhood predictors. Journal of Child Psychology and Psychiatry, 48, 1102–1110. CrossRefPubMed Billstedt, E., Gillberg, I. C., & Gillberg, C. (2007). Autism in adult: Symptom patterns and early childhood predictors. Journal of Child Psychology and Psychiatry, 48, 1102–1110. CrossRefPubMed
go back to reference Bishop, S. L., Richler, J., Cain, A. C., & Lord, C. (2007). Predictors of perceived negative impact in moterhs of children with autism spectrum disorder. American Journal on Mental Retardation, 112, 450–461. CrossRefPubMed Bishop, S. L., Richler, J., Cain, A. C., & Lord, C. (2007). Predictors of perceived negative impact in moterhs of children with autism spectrum disorder. American Journal on Mental Retardation, 112, 450–461. CrossRefPubMed
go back to reference Bolton, P. F., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: Patterns of familial aggregation. Psychological Medicine, 28, 385–395. CrossRefPubMed Bolton, P. F., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: Patterns of familial aggregation. Psychological Medicine, 28, 385–395. CrossRefPubMed
go back to reference Brune, C. W., Kim, S.-J., Hanna, G. L., Courchesne, E., Lord, C., Leventhal, B. L., et al. (2008). Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample. Autism Research, 1, 108–113. CrossRefPubMed Brune, C. W., Kim, S.-J., Hanna, G. L., Courchesne, E., Lord, C., Leventhal, B. L., et al. (2008). Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample. Autism Research, 1, 108–113. CrossRefPubMed
go back to reference Brune, C. W., Kim, S. J., Salt, J., Leventhal, B. L., Lord, C., & Cook, E. H. Jr. (2006). 5-HTTLPR genotype-specific phenotype in children and adolescents with autism. American Journal of Psychiatry, 163, 2148–2156. CrossRefPubMed Brune, C. W., Kim, S. J., Salt, J., Leventhal, B. L., Lord, C., & Cook, E. H. Jr. (2006). 5-HTTLPR genotype-specific phenotype in children and adolescents with autism. American Journal of Psychiatry, 163, 2148–2156. CrossRefPubMed
go back to reference Carcani-Rathwell, I., Rabe-Hasketh, S., & Santosh, P. J. (2006). Repetitive and stereotyped behaviours in pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 47, 573–581. CrossRefPubMed Carcani-Rathwell, I., Rabe-Hasketh, S., & Santosh, P. J. (2006). Repetitive and stereotyped behaviours in pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 47, 573–581. CrossRefPubMed
go back to reference Cath, D. C., Ran, N., Smit, J. H., van Balkom, A. J. L. M., & Comijs, H. C. (2008). Symptom overlap between autism spectrum disorder, generalized anxiety disorder and obsessive-compulsive disorder in adults: A preliminary case-controlled study. Psychopahtology, 41, 101–110. CrossRef Cath, D. C., Ran, N., Smit, J. H., van Balkom, A. J. L. M., & Comijs, H. C. (2008). Symptom overlap between autism spectrum disorder, generalized anxiety disorder and obsessive-compulsive disorder in adults: A preliminary case-controlled study. Psychopahtology, 41, 101–110. CrossRef
go back to reference Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Mahwah, NJ: Lawrence Erlbaum. Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Mahwah, NJ: Lawrence Erlbaum.
go back to reference Cohen, J. (1994). The earth is round ( p < .05). American Psychologist, 49, 997–1003. CrossRef Cohen, J. (1994). The earth is round ( p < .05). American Psychologist, 49, 997–1003. CrossRef
go back to reference Cohen, I. L., Liu, X., Schultz, C., White, B. N., Jenkins, E. C., Brown, W. T., et al. (2003). Association of autism severity with a monoamine oxidase a functional polymorphism. Clinical Genetics, 64, 90–197. CrossRef Cohen, I. L., Liu, X., Schultz, C., White, B. N., Jenkins, E. C., Brown, W. T., et al. (2003). Association of autism severity with a monoamine oxidase a functional polymorphism. Clinical Genetics, 64, 90–197. CrossRef
go back to reference Comings, D. E. (1990). Tourette syndrome and human behavior. Duarte, CA: Hope Press. Comings, D. E. (1990). Tourette syndrome and human behavior. Duarte, CA: Hope Press.
go back to reference Comings, D. E., Wu, S., Chiu, C., Ring, R. H., Gade, R., Ahn, C., et al. (1996). Polygenetic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 67B, 264–288. Comings, D. E., Wu, S., Chiu, C., Ring, R. H., Gade, R., Ahn, C., et al. (1996). Polygenetic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 67B, 264–288.
go back to reference Coon, H., Dunn, D., Lainhart, J., Miller, J., Hamil, C., Battaglia, A., et al. (2005). Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene ( TPH2). American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 135B, 42–46. CrossRef Coon, H., Dunn, D., Lainhart, J., Miller, J., Hamil, C., Battaglia, A., et al. (2005). Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene ( TPH2). American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 135B, 42–46. CrossRef
go back to reference Cullen, B., Samuels, J., Grados, M., Landa, R., Bienvenu, O. J., Liang, K.-Y., et al. (2008). Social and communication difficulties and obsessive-compulsive disorder. Psychopathology, 41, 194–200. CrossRefPubMed Cullen, B., Samuels, J., Grados, M., Landa, R., Bienvenu, O. J., Liang, K.-Y., et al. (2008). Social and communication difficulties and obsessive-compulsive disorder. Psychopathology, 41, 194–200. CrossRefPubMed
go back to reference Dickel, D. E., Veenstra-Vander Weele, J., Cox, N. J., Wu, X., Fischer, D. J., Van Etten-Lee, M., et al. (2006). Association testing of the positional and functional candidate gen SLOC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Archives of General Psychiatry, 63, 778–785. CrossRefPubMed Dickel, D. E., Veenstra-Vander Weele, J., Cox, N. J., Wu, X., Fischer, D. J., Van Etten-Lee, M., et al. (2006). Association testing of the positional and functional candidate gen SLOC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Archives of General Psychiatry, 63, 778–785. CrossRefPubMed
go back to reference Feise, R. J. (2002). Do multiple outcome measures require p-value adjustment? BMC Medical Research Methodology, 2. Feise, R. J. (2002). Do multiple outcome measures require p-value adjustment? BMC Medical Research Methodology, 2.
go back to reference Flint, J., & Mackay, T. F. C. (2009). Genetic architecture of quantitative traits in mice, flies, and humans. Genome Research, 19, 723–733. CrossRefPubMed Flint, J., & Mackay, T. F. C. (2009). Genetic architecture of quantitative traits in mice, flies, and humans. Genome Research, 19, 723–733. CrossRefPubMed
go back to reference Fong, L., Wilgosh, L., & Sobsey, D. (1993). The experience of parenting an adolescent with autism. International Journal of Disability, Development, and Education, 40, 105–113. CrossRef Fong, L., Wilgosh, L., & Sobsey, D. (1993). The experience of parenting an adolescent with autism. International Journal of Disability, Development, and Education, 40, 105–113. CrossRef
go back to reference Gadow, K.D., DeVincent, C.J., Olvet, D.M., & Hatchwell, E. (2009a). Association of DRD4 polymorphism with severity oppositional defiant, separation anxiety, and repetitive behaviors in children with autism spectrum disorder. Manuscript submitted for publication. Gadow, K.D., DeVincent, C.J., Olvet, D.M., & Hatchwell, E. (2009a). Association of DRD4 polymorphism with severity oppositional defiant, separation anxiety, and repetitive behaviors in children with autism spectrum disorder. Manuscript submitted for publication.
go back to reference Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-aged children with PDD versus clinic and community samples. Autism, 9, 392–415. CrossRefPubMed Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-aged children with PDD versus clinic and community samples. Autism, 9, 392–415. CrossRefPubMed
go back to reference Gadow, K. D., Nolan, E. E., Sprafkin, J., & Schwartz, J. (2002). Tics and psychiatric comorbidity in children and adolescents. Developmental Medicine and Child Neurology, 44, 330–338. CrossRefPubMed Gadow, K. D., Nolan, E. E., Sprafkin, J., & Schwartz, J. (2002). Tics and psychiatric comorbidity in children and adolescents. Developmental Medicine and Child Neurology, 44, 330–338. CrossRefPubMed
go back to reference Gadow, K. D., Roohi, J., DeVincent, C. J., & Hatchwell, E. (2008a). Association of ADHD, tics, and anxiety with dopamine transporter ( DAT1) genotype in autism spectrum disorder. Journal of Child Psychology and Psychiatry, 49, 1331–1338. CrossRefPubMed Gadow, K. D., Roohi, J., DeVincent, C. J., & Hatchwell, E. (2008a). Association of ADHD, tics, and anxiety with dopamine transporter ( DAT1) genotype in autism spectrum disorder. Journal of Child Psychology and Psychiatry, 49, 1331–1338. CrossRefPubMed
go back to reference Gadow, K.D., Roohi, J., DeVincent, C.J., Kirsch, S., & Hatchwell, E. (2009b). Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74. Gadow, K.D., Roohi, J., DeVincent, C.J., Kirsch, S., & Hatchwell, E. (2009b). Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74.
go back to reference Gadow, K. D., Schwartz, J., DeVincent, C., Strong, G., & Cuva, S. (2008b). Clinical utility of autism spectrum disorder scoring algorithms for the child symptom inventory. Journal of Autism and Developmental Disorders, 38, 419–427. CrossRefPubMed Gadow, K. D., Schwartz, J., DeVincent, C., Strong, G., & Cuva, S. (2008b). Clinical utility of autism spectrum disorder scoring algorithms for the child symptom inventory. Journal of Autism and Developmental Disorders, 38, 419–427. CrossRefPubMed
go back to reference Gadow, K. D., & Sprafkin, J. (1986). Stony Brook Child Psychiatric Checklist-3. Stony Brook: Department of Psychiatry, State University of New York. Gadow, K. D., & Sprafkin, J. (1986). Stony Brook Child Psychiatric Checklist-3. Stony Brook: Department of Psychiatry, State University of New York.
go back to reference Gadow, K. D., & Sprafkin, J. (2002). Child Symptom Inventory-4 Screening and Norms Manual. Checkmate Plus: Stony Brook, NY. Gadow, K. D., & Sprafkin, J. (2002). Child Symptom Inventory-4 Screening and Norms Manual. Checkmate Plus: Stony Brook, NY.
go back to reference Grados, M. A., Mathews, C. A., & Tourette Syndrome Association International Consortium for Genetics. (2008). Latent class analysis of Gilles de la Tourette syndrome using comorbidities: Clinical and genetic implications. Biological Psychiatry, 64, 219–225. CrossRefPubMed Grados, M. A., Mathews, C. A., & Tourette Syndrome Association International Consortium for Genetics. (2008). Latent class analysis of Gilles de la Tourette syndrome using comorbidities: Clinical and genetic implications. Biological Psychiatry, 64, 219–225. CrossRefPubMed
go back to reference Hollingshead, A. B. (1975). Four Factor Index of Social Status. Department of Sociology, Yale University: New Haven, CT. Hollingshead, A. B. (1975). Four Factor Index of Social Status. Department of Sociology, Yale University: New Haven, CT.
go back to reference Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004). Adult outcome for children with autism. Journal of Child Psychology and Psychiatry, 45, 212–229. CrossRefPubMed Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004). Adult outcome for children with autism. Journal of Child Psychology and Psychiatry, 45, 212–229. CrossRefPubMed
go back to reference Lam, K. S. L., Bodfish, J. W., & Piven, J. (2008). Evidence for three subtypes of repetitive behavior in autism that differ in familiarity and association with other symptoms. Journal of Child Psychology and Psychiatry, 49, 1193–1200. PubMed Lam, K. S. L., Bodfish, J. W., & Piven, J. (2008). Evidence for three subtypes of repetitive behavior in autism that differ in familiarity and association with other symptoms. Journal of Child Psychology and Psychiatry, 49, 1193–1200. PubMed
go back to reference Lecavalier, L., Gadow, K. D., DeVincent, C. J., & Edwards, M. C. (2009a). Validation of DSM-IV model of psychiatric syndromes in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 278–289. CrossRefPubMed Lecavalier, L., Gadow, K. D., DeVincent, C. J., & Edwards, M. C. (2009a). Validation of DSM-IV model of psychiatric syndromes in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 278–289. CrossRefPubMed
go back to reference Lecavalier, L., Gadow, K. D., DeVincent, C. J., Houts, C., & Edwards, M. C. (2009b). Deconstructing the PDD clinical phenotype: Internal validity of the DSM-IV. Journal of Child Psychology and Psychiatry, 50, 1246–1254. CrossRefPubMed Lecavalier, L., Gadow, K. D., DeVincent, C. J., Houts, C., & Edwards, M. C. (2009b). Deconstructing the PDD clinical phenotype: Internal validity of the DSM-IV. Journal of Child Psychology and Psychiatry, 50, 1246–1254. CrossRefPubMed
go back to reference Lecavalier, L., Leone, S., & Wiltz, J. (2006). The impact of behaviour problems on caregiver stress in young people with autism spectrum disorders. Journal of Intellectual Disability Research, 50, 172–183. CrossRefPubMed Lecavalier, L., Leone, S., & Wiltz, J. (2006). The impact of behaviour problems on caregiver stress in young people with autism spectrum disorders. Journal of Intellectual Disability Research, 50, 172–183. CrossRefPubMed
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. CrossRefPubMed Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. CrossRefPubMed
go back to reference Mandy, W. P. L., & Skuse, D. H. (2008). Research review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities? Child Psychology and Psychiatry, 49, 795–808. CrossRef Mandy, W. P. L., & Skuse, D. H. (2008). Research review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities? Child Psychology and Psychiatry, 49, 795–808. CrossRef
go back to reference Matson, J. L., & Dempsey, T. (2009). The nature and treatment of compulsions, obsessions, and rituals in people with developmental disabilities. Research in Developmental Disabilities, 30, 603–611. CrossRefPubMed Matson, J. L., & Dempsey, T. (2009). The nature and treatment of compulsions, obsessions, and rituals in people with developmental disabilities. Research in Developmental Disabilities, 30, 603–611. CrossRefPubMed
go back to reference Moss, J., Oliver, C., Arron, K., Burbidge, C., & Berg, K. (2009). The prevelance and phenomenology of repetitive behavior in genetic syndromes. Journal of Autism and Developmental Disorders, 39, 572–588. CrossRefPubMed Moss, J., Oliver, C., Arron, K., Burbidge, C., & Berg, K. (2009). The prevelance and phenomenology of repetitive behavior in genetic syndromes. Journal of Autism and Developmental Disorders, 39, 572–588. CrossRefPubMed
go back to reference Mulder, E. J., Anderson, G. M., Kema, I. P., Brugman, A. M., Ketelaars, C. E. J., de Bildt, A., et al. (2005). Serotonin transporter intron 2 polymorphism associated with rigid-compulsive behaviors in Dutch individuals with pervasive developmental disorder. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, B133, 93–96. CrossRef Mulder, E. J., Anderson, G. M., Kema, I. P., Brugman, A. M., Ketelaars, C. E. J., de Bildt, A., et al. (2005). Serotonin transporter intron 2 polymorphism associated with rigid-compulsive behaviors in Dutch individuals with pervasive developmental disorder. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, B133, 93–96. CrossRef
go back to reference Perneger, T. V. (1998). What’s wrong with Bonferroni adjustments. BMJ, 316, 1236–1238. PubMed Perneger, T. V. (1998). What’s wrong with Bonferroni adjustments. BMJ, 316, 1236–1238. PubMed
go back to reference Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from family study of multiple-incidence autistic families. American Journal of Psychiatry, 156, 557–563. PubMed Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from family study of multiple-incidence autistic families. American Journal of Psychiatry, 156, 557–563. PubMed
go back to reference Roohi, J., DeVincent, C. J., Hatchwell, E., & Gadow, K. D. (2009). Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74. CrossRefPubMed Roohi, J., DeVincent, C. J., Hatchwell, E., & Gadow, K. D. (2009). Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. Journal of Autism and Developmental Disorders, 39, 67–74. CrossRefPubMed
go back to reference Rowe, D. C., Stever, C., Gard, J. M. C., Cleveland, H. H., Sanders, M. L., Abramowitz, A., et al. (1998). The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behavior Genetics, 28, 215–225. CrossRefPubMed Rowe, D. C., Stever, C., Gard, J. M. C., Cleveland, H. H., Sanders, M. L., Abramowitz, A., et al. (1998). The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behavior Genetics, 28, 215–225. CrossRefPubMed
go back to reference Rutter, M., LeCouteur, A., & Lord, C. (2003). Autism Diagnostic Interview-Revised. Western Psychological Services: Los Angeles, CA. Rutter, M., LeCouteur, A., & Lord, C. (2003). Autism Diagnostic Interview-Revised. Western Psychological Services: Los Angeles, CA.
go back to reference Sacco, R., Papaleo, V., Hager, J., Rousseau, F., Moessner, R., Militerni, R., et al. (2007). Case-control and family-based association studies of candidate gene in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC Medical Genetics, 8, 11. CrossRefPubMed Sacco, R., Papaleo, V., Hager, J., Rousseau, F., Moessner, R., Militerni, R., et al. (2007). Case-control and family-based association studies of candidate gene in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC Medical Genetics, 8, 11. CrossRefPubMed
go back to reference Sakurai, T., Reichert, J., Hoffman, E. J., Cai, G., Jones, H. B., Faham, M., et al. (2008). A large-scale screen for coding variants in SERT/ SLC6A4 in autism spectrum disorders. Autism Research, 1, 251–257. CrossRefPubMed Sakurai, T., Reichert, J., Hoffman, E. J., Cai, G., Jones, H. B., Faham, M., et al. (2008). A large-scale screen for coding variants in SERT/ SLC6A4 in autism spectrum disorders. Autism Research, 1, 251–257. CrossRefPubMed
go back to reference Stewart, S. E., Fagerness, J. A., Platko, J., Smoller, J. W., Scharf, J. M., Illmann, C., et al. (2007). Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. American Journal of Medical Genetics Part B Neurospychiatric Genetics, 144B, 1027–1033. CrossRef Stewart, S. E., Fagerness, J. A., Platko, J., Smoller, J. W., Scharf, J. M., Illmann, C., et al. (2007). Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. American Journal of Medical Genetics Part B Neurospychiatric Genetics, 144B, 1027–1033. CrossRef
go back to reference Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., McCauley, J. L., Han, Q., Jiang, L., et al. (2005). Allelic heterogeneity at the serotonin transporter locus ( SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American Journal of Human Genetics, 77, 265–279. CrossRefPubMed Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., McCauley, J. L., Han, Q., Jiang, L., et al. (2005). Allelic heterogeneity at the serotonin transporter locus ( SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American Journal of Human Genetics, 77, 265–279. CrossRefPubMed
go back to reference Tordjman, S., Gutknecht, L., Carlier, M., Spitz, E., Antoine, C., Slama, F., et al. (2001). Role of the serotonin transporter gene in the behavioral expression of autism. Molecular Psychiatry, 6, 434–439. CrossRefPubMed Tordjman, S., Gutknecht, L., Carlier, M., Spitz, E., Antoine, C., Slama, F., et al. (2001). Role of the serotonin transporter gene in the behavioral expression of autism. Molecular Psychiatry, 6, 434–439. CrossRefPubMed
go back to reference Wang, Y., Adamczyk, A., Shugart, Y.Y., Samuels, J.F., Grados, M.A., Greenberg, B.D., et al. (2009). A screen of SLC1A1 for OCD-related alleles. American Journal of Medical Genetics Part B. doi 10.​1002/​ajmg.​b.​31001. Wang, Y., Adamczyk, A., Shugart, Y.Y., Samuels, J.F., Grados, M.A., Greenberg, B.D., et al. (2009). A screen of SLC1A1 for OCD-related alleles. American Journal of Medical Genetics Part B. doi 10.​1002/​ajmg.​b.​31001.
go back to reference Wendland, J. R., Moya, P. R., Timpano, K. R., Anavitarte, A. P., Kruse, M. R., Wheaton, M. G., et al. (2009). A haplotype containing quantitative trait loci for SLC 1A1 gene expression and its association with obsessive-compulsive disorder. Archives of General Psychiatry, 66, 408–416. CrossRefPubMed Wendland, J. R., Moya, P. R., Timpano, K. R., Anavitarte, A. P., Kruse, M. R., Wheaton, M. G., et al. (2009). A haplotype containing quantitative trait loci for SLC 1A1 gene expression and its association with obsessive-compulsive disorder. Archives of General Psychiatry, 66, 408–416. CrossRefPubMed
go back to reference White, S.W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29, 216–229. White, S.W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29, 216–229.
go back to reference Wood, J.J., Drahota, A., Sze, K., Har, K., Chiu, A., & Langer, D.A. (2008). Cognitive behavioural therapy for anxiety in children with autism Spectrum disorders: a randomized, controlled trial. Journal of Child Psychology and Psychiatry, 50, 224–234. Wood, J.J., Drahota, A., Sze, K., Har, K., Chiu, A., & Langer, D.A. (2008). Cognitive behavioural therapy for anxiety in children with autism Spectrum disorders: a randomized, controlled trial. Journal of Child Psychology and Psychiatry, 50, 224–234.
go back to reference Zandt, F., Prior, M., & Kyrios, M. (2007). Repetitive behaviour in children with high functioning autism and obsessive compulsive disorder. Journal of Autism and Developmental Disorders, 37, 251–259. CrossRefPubMed Zandt, F., Prior, M., & Kyrios, M. (2007). Repetitive behaviour in children with high functioning autism and obsessive compulsive disorder. Journal of Autism and Developmental Disorders, 37, 251–259. CrossRefPubMed
go back to reference Zhang, J., Quan, H., Ng, J., & Stepanavage, M. E. (1997). Some statistical methods for multiple endpoints in clinical trials. Controlled Clinical Trials, 18, 204–221. CrossRefPubMed Zhang, J., Quan, H., Ng, J., & Stepanavage, M. E. (1997). Some statistical methods for multiple endpoints in clinical trials. Controlled Clinical Trials, 18, 204–221. CrossRefPubMed
go back to reference Zhou, L., Myers, A. N., Vandersteen, J. G., Wang, L., & Wittwer, C. T. (2004). Closed-tube genotyping with unlabeled oligonucleotide probes and a saturating DNA dye. Clinical Chemistry, 50, 328–335. Epub 2004 May 27. CrossRef Zhou, L., Myers, A. N., Vandersteen, J. G., Wang, L., & Wittwer, C. T. (2004). Closed-tube genotyping with unlabeled oligonucleotide probes and a saturating DNA dye. Clinical Chemistry, 50, 328–335. Epub 2004 May 27. CrossRef
Metagegevens
Titel
Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder
Auteurs
Kenneth D. Gadow
Jasmin Roohi
Carla J. DeVincent
Sarah Kirsch
Eli Hatchwell
Publicatiedatum
01-09-2010
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-0961-7