Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2020

06-03-2020 | Original Paper

Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder

Auteurs: Yan Li, Shuang Qiu, Weijing Zhong, Yong Li, Yunkai Liu, Yi Cheng, Yawen Liu

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case–control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T–A haplotype (rs2229082–rs2270954), T–A–T–C haplotype (rs2229082–rs2270954–rs2292043–rs2292044), C–G–T–C–T haplotype (rs934345–rs17753970–rs2229082–rs2270954–rs2292043), C–G–T–C–T–G haplotype (rs934345–rs17753970–rs2229082–rs2270954–rs2292043–rs2292044), and G–G–T–C–C–C–C haplotype (rs934345–rs17753970–rs2229082–rs2270954–rs2292043–rs2292044–rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD.

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijf je als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen jouw vak. Met het online abonnement heb je toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kun je op je gemak en wanneer het jou het beste uitkomt verdiepen in jouw vakgebied.

Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Bamias, A. T., Bai, M. C., Agnantis, N. J., Michael, M. C., Alamanos, Y. P., Stefanaki, S. V., et al. (2003). Prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma. Cancer Investigation, 21(3), 333–340. CrossRef Bamias, A. T., Bai, M. C., Agnantis, N. J., Michael, M. C., Alamanos, Y. P., Stefanaki, S. V., et al. (2003). Prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma. Cancer Investigation, 21(3), 333–340. CrossRef
go back to reference Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2012. MMWR Surveillance Summaries, 65(3), 1–23. https://​doi.​org/​10.​15585/​mmwr.​ss6503a1. CrossRef Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2012. MMWR Surveillance Summaries, 65(3), 1–23. https://​doi.​org/​10.​15585/​mmwr.​ss6503a1. CrossRef
go back to reference Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15(9), 409–416. CrossRef Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15(9), 409–416. CrossRef
go back to reference Ho, K. Y., Kalle, W. H., Lo, T. H., Lam, W. Y., & Tang, C. M. (1999). Reduced expression of APC and DCC gene protein in breast cancer. Histopathology, 35(3), 249–256. CrossRef Ho, K. Y., Kalle, W. H., Lo, T. H., Lam, W. Y., & Tang, C. M. (1999). Reduced expression of APC and DCC gene protein in breast cancer. Histopathology, 35(3), 249–256. CrossRef
go back to reference Huang, Y., Boynton, R. F., Blount, P. L., Silverstein, R. J., Yin, J., Tong, Y., et al. (1992). Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers. Cancer Research, 52(23), 6525–6530. PubMed Huang, Y., Boynton, R. F., Blount, P. L., Silverstein, R. J., Yin, J., Tong, Y., et al. (1992). Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers. Cancer Research, 52(23), 6525–6530. PubMed
go back to reference Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E. D., Chan, S. S., Culotti, J. G., et al. (1996). Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell, 87(2), 175–185. CrossRef Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E. D., Chan, S. S., Culotti, J. G., et al. (1996). Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell, 87(2), 175–185. CrossRef
go back to reference Kohno, T., Sato, T., Takakura, S., Takei, K., Inoue, K., Nishioka, M., et al. (2000). Mutation and expression of the DCC gene in human lung cancer. Neoplasia, 2(4), 300–305. CrossRef Kohno, T., Sato, T., Takakura, S., Takei, K., Inoue, K., Nishioka, M., et al. (2000). Mutation and expression of the DCC gene in human lung cancer. Neoplasia, 2(4), 300–305. CrossRef
go back to reference Rothman, K. J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1(1), 43–46. CrossRef Rothman, K. J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1(1), 43–46. CrossRef
go back to reference Saville, D. J. (1990). Multiple comparison procedures: The practical solution. American Statistician, 44(2), 174–180. Saville, D. J. (1990). Multiple comparison procedures: The practical solution. American Statistician, 44(2), 174–180.
go back to reference Templeton, A. R. (1995). A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus. Genetics, 140(1), 403. PubMedPubMedCentral Templeton, A. R. (1995). A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus. Genetics, 140(1), 403. PubMedPubMedCentral
Metagegevens
Titel
Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder
Auteurs
Yan Li
Shuang Qiu
Weijing Zhong
Yong Li
Yunkai Liu
Yi Cheng
Yawen Liu
Publicatiedatum
06-03-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04417-3