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06-03-2020 | Original Paper

Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder

Tijdschrift:: Journal of Autism and Developmental Disorders

Auteurs:: Yan Li, Shuang Qiu, Weijing Zhong, Yong Li, Yunkai Liu, Yi Cheng, Yawen Liu

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Abstract

Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case–control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T–A haplotype (rs2229082–rs2270954), T–A–T–C haplotype (rs2229082–rs2270954–rs2292043–rs2292044), C–G–T–C–T haplotype (rs934345–rs17753970–rs2229082–rs2270954–rs2292043), C–G–T–C–T–G haplotype (rs934345–rs17753970–rs2229082–rs2270954–rs2292043–rs2292044), and G–G–T–C–C–C–C haplotype (rs934345–rs17753970–rs2229082–rs2270954–rs2292043–rs2292044–rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD.

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Titel: Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder
Auteurs:: Yan Li
Shuang Qiu
Weijing Zhong
Yong Li
Yunkai Liu
Yi Cheng
Yawen Liu
Publicatiedatum: 06-03-2020
DOI: https://doi.org/10.1007/s10803-020-04417-3
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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