Skip to main content


Swipe om te navigeren naar een ander artikel

02-03-2016 | Review Article | Uitgave 4/2016 Open Access

Netherlands Heart Journal 4/2016

Animal models of heart failure with preserved ejection fraction

Netherlands Heart Journal > Uitgave 4/2016
G. Conceição, I. Heinonen, A. P. Lourenço, D. J. Duncker, I. Falcão-Pires
Belangrijke opmerkingen
G. Conceição and I. Heinonen both authors contributed equally.


Heart failure with preserved ejection fraction (HFpEF) constitutes a clinical syndrome in which the diagnostic criteria of heart failure are not accompanied by gross disturbances of systolic function, as assessed by ejection fraction. In turn, under most circumstances, diastolic function is impaired. Although it now represents over 50 % of all patients with heart failure, the mechanisms of HFpEF remain understood, precluding effective therapy. Understanding the pathophysiology of HFpEF has been restricted by both limited access to human myocardial biopsies and by the lack of animal models that fully mimic human pathology. Animal models are valuable research tools to clarify subcellular and molecular mechanisms under conditions where the comorbidities and other confounding factors can be precisely controlled. Although most of the heart failure animal models currently available represent heart failure with reduced ejection fraction, several HFpEF animal models have been proposed. However, few of these fulfil all the features present in human disease. In this review we will provide an overview of the currently available models to study HFpEF from rodents to large animals as well as present advantages and disadvantages of these models.

Onze productaanbevelingen

Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

Over dit artikel

Andere artikelen Uitgave 4/2016

Netherlands Heart Journal 4/2016 Naar de uitgave