Swipe om te navigeren naar een ander artikel
G. Conceição and I. Heinonen both authors contributed equally.
Heart failure with preserved ejection fraction (HFpEF) constitutes a clinical syndrome in which the diagnostic criteria of heart failure are not accompanied by gross disturbances of systolic function, as assessed by ejection fraction. In turn, under most circumstances, diastolic function is impaired. Although it now represents over 50 % of all patients with heart failure, the mechanisms of HFpEF remain understood, precluding effective therapy. Understanding the pathophysiology of HFpEF has been restricted by both limited access to human myocardial biopsies and by the lack of animal models that fully mimic human pathology. Animal models are valuable research tools to clarify subcellular and molecular mechanisms under conditions where the comorbidities and other confounding factors can be precisely controlled. Although most of the heart failure animal models currently available represent heart failure with reduced ejection fraction, several HFpEF animal models have been proposed. However, few of these fulfil all the features present in human disease. In this review we will provide an overview of the currently available models to study HFpEF from rodents to large animals as well as present advantages and disadvantages of these models.
Regan JA, Mauro AG, Carbone S, et al. A Mouse Model of Heart Failure with Preserved Ejection Fraction due to Chronic Infusion of a Low Subpressor Dose of Angiotensin II. Am J Physiol Heart Circ Physiol. 2015:H771–8.
Litwin SE, Katz SE, Weinberg EO, et al. Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation. 1995;91:2642–54. CrossRefPubMed
Abe T, Ohga Y, Tabayashi N, et al. Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats. Am J Physiol Heart Circ Physiol. 2002;282:H138–48. PubMed
Abrahams C, Janicki JS, Weber KT., Myocardial hypertrophy in Macaca fascicularis. Structural remodeling of the collagen matrix. Lab Invest. 1987;56:676–83. PubMed
Falcao-Pires I, Leite-Moreira AF. Animal Models of Cardiovascular Disease. In: Cokkinos DV, editor Introduction to Translational Cardiovascular Research: Springer International Publishing; 2015. p. 335–69.
Halapas A, Papalois A, Stauropoulou A, et al. In vivo models for heart failure research. In Vivo. 2008;22:767–80. PubMed
- Animal models of heart failure with preserved ejection fraction
A. P. Lourenço
D. J. Duncker
- Bohn Stafleu van Loghum