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Journal of Autism and Developmental Disorders

23-04-2024 | Original Article

Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health

Auteurs: Amrita Minhas, Kerri Whitlock, Cory Rosenfelt, Julie Shatto, Brittany Finlay, Jennifer Zwicker, Sarah Lippe, Sebastien Jacquemont, Randi Hagerman, Kara Murias, Francois V. Bolduc

Gepubliceerd in: Journal of Autism and Developmental Disorders

Abstract

The purpose of this paper was to examine the physical, emotional, social and school functioning domains of quality of life of individuals with Fragile X Syndrome, in relation to mental health and sleep patterns to gain a better understanding of how these aspects are affected by the disorder. This study included 119 individuals with Fragile X Syndrome who were given different cognitive examinations by a neuropsychologist or by parent-proxy questionnaires. This study focused on the Pediatric Quality of Life Inventory (PedsQoL), the Anxiety, Depression and Mood Scale (ADAMS), the Children’s Sleep Habits Questionnaire (CSHQ), but did include other cognitive tests (Vineland Adaptive Behaviour Scales, Nonverbal IQ, Autism Diagnostic Observation Schedule). We identified significant associations between decreases in emotional, social and school domains of PedsQoL and the ADAMS subtests of Generalized Anxiety, Manic/Hyperactivity and Obsessive/Compulsivity, with the subtest of Depressed Mood having associations with lower physical and emotional domains. We also identified a significant impact between CSHQ subtests of Sleep Anxiety, Night Wakings, Daytime Sleepiness, and Parasomnia with the emotional and school domains of PedsQoL. There were associations connecting school functioning with Bedtime Resistance, and additional associations connecting emotional functioning with Sleep Duration and Sleep Onset Delay. Physical functioning was also associated with Sleep Anxiety. Our study shows how mental health and sleep defects impact improper sleep patterns and mental health which leads to decreases in the quality of life for individuals with FXS, and how it is important to screen for these symptoms in order to alleviate issues.

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Titel: Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health
Auteurs: Amrita Minhas
Kerri Whitlock
Cory Rosenfelt
Julie Shatto
Brittany Finlay
Jennifer Zwicker
Sarah Lippe
Sebastien Jacquemont
Randi Hagerman
Kara Murias
Francois V. Bolduc
Publicatiedatum: 23-04-2024
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-024-06317-2

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