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Gepubliceerd in:
Biomoleculen biomoleculen hoofdstuk lezen eerste hoofdstuk lezen

2015 | OriginalPaper | Hoofdstuk

9. Aminozuurmetabolisme

Auteur : Frans C. Schuit

Gepubliceerd in: Leerboek metabolisme

Uitgeverij: Bohn Stafleu van Loghum

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Samenvatting

Hoofdstuk 9 behandelt een netwerk van metabole wegen die bewerkstelligen dat de twintig verschillende aminozuren voor eiwitsynthese voorradig zijn en dat er afgeleide moleculen kunnen worden bijgemaakt. Het hoofdstuk begint met het verschil tussen essentiële en niet-essentiële aminozuren. Alleen niet-essentiële aminozuren kunnen door de mens worden gemaakt; de essentiële aminozuren worden via de voeding in het lichaam opgenomen. Bij de afbraak van overtollige aminozuren besteden we aandacht aan stikstofeliminatie: het voor de hersenen toxische ammoniak wordt in de lever veilig in ureum verwerkt, dat in de urine wordt uitgescheiden. Inborn errors van het aminozuurmetabolisme zijn alkaptonurie, albinisme en fenylketonurie: voor de laatste worden alle pasgeboren baby’s gescreend. Een belangrijke afgeleide van glycine en succinyl-CoA is heem dat gebruikt wordt in hemoglobine en cytochromen; afbraak van deze stof levert bilirubine op die in de gal wordt uitgescheiden als diglucuronide. Andere van aminozuren afgeleide stoffen zijn polyaminen, stikstofmonoxide, catecholaminen, serotonine, melatonine, histamine en schildklierhormoon.
vorige hoofdstuk Vetzuur- en cholesterolafgeleiden
volgende hoofdstuk Nucleotidenmetabolisme
Literatuur
Albrecht, J., Sidoryk-Węgrzynowicz, M., Zielińska, M. & Aschner, M. (2010). Roles of glutamine in neurotransmission. Neuron Glia Biol. 6, 263–276.CrossRefPubMed
Akdis, C.A., Jutel, M. & Akdis, M. (2008). Regulatory effects of histamine & histamine receptor expression in human allergic immune responses. Chem. Immunol. Allergy. 94, 67–82.
Arch, J.R. (2002). Beta(3)-Adrenoceptor agonists: potential, pitfalls and progress. Eur J Pharmacol. 440, 99–107.CrossRefPubMed
Autti-Rämö, I., et al. (2005). Expanding screening for rare metabolic disease in the newborn: an analysis of costs, effect and ethical consequences for decision-making in Finland. Acta Paediatr. 94, 1126–1136.CrossRefPubMed
Baker, DH. (2005). Comparative nutrition and metabolism: explication of open questions with emphasis on protein and amino acids. Proc. Natl. Acad. Sci. U.S.A. 102, 17897–17902.CrossRefPubMedPubMedCentral
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proenca, C., Sparso, T., Holmkvist, J., Marchand, M. et al. (2009). A variant near MTNR1B is associated with increased fasting plasma glucose levels & type 2 diabetes risk. Nat. Genet. 41, 89–94.CrossRefPubMed
Braissant, O. & Henry, H. (2008). AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: a review. J Inherit Metab Dis. 31, 230–239.CrossRefPubMed
Brosnan, J.T. & Brosnan, M.E. (2007). Creatine: Endogenous metabolite, dietary, & therapeutic supplement. Ann. Rev. Nutr. 27, 241–261.
Brosnan, M.E. & Brosnan, J.T. (2009). Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am. J. Clin. Nutr. 90, 857S–861S.CrossRefPubMed
Bult, H., Boeckxstaens, G.E., Pelckmans, P.A., Jordaens, F.H., Van Maercke, Y.M. & Herman, A.G. (1990). Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 345, 346–347.CrossRefPubMed
Camp, K.M., Lloyd-Puryear, M.A. & Huntington, K.L. (2012). Nutritional treatment for inborn errors of metabolism: indications, regulations, and availability of medical foods and dietary supplements using phenylketonuria as an example. Mol Genet Metab. 107, 3–9.CrossRefPubMedPubMedCentral
Caruso, J., Charles. J., Unruh, K., Giebel, R., Learmonth, L. & Potter, W. (2012). Ergogenic effects of β-alanine and carnosine: proposed future research to quantify their efficacy. Nutrients. 4, 585–601.CrossRefPubMedPubMedCentral
Childs, A.C., Mehta, D.J. & Gerner, E.W. (2003). Polyamine-dependent gene expression. Cell Mol. Life Sci. 60, 1394–1406.CrossRefPubMed
Cote, F., Fligny, C., Bayard, E., Launay, J.M., Gershon, M.D., Mallet, J. et al. (2007). Maternal serotonin is crucial for murine embryonic development. Proc. Natl. Acad. Sci. U. S. A. 104, 329–334.CrossRefPubMed
Derave, W., Ozdemir, M.S., Harris, R.C., Pottier, A., Reyngoudt, H., Koppo, K., Wise, J.A. & Achten, E. (2007). Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol. 103, 1736–1743.CrossRefPubMed
Endo, F., Matsuura, T., Yanagita, K. & Matsuda, I. (2004). Clinical manifestations of inborn errors of the urea cycle & related metabolic disorders during childhood. J. Nutr. 134, 1605S–1609S.CrossRefPubMed
Flora, G., Gupta, D. & Tiwari A. (2012). Toxicity of lead: A review with recent updates. Interdiscip Toxicol. 5, 47–58.
Foulkes, N.S., Borjigin, J., Snyder, S.H. & Sassone-Corsi, P. (1997). Rhythmic transcription: the molecular basis of circadian melatonin synthesis. Trends Neurosci. 20, 487–492.CrossRefPubMed
Furchgott, R.F. & Zawadzki, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288, 373–376.CrossRefPubMed
Furchgott, R.F., Cherry, P.D., Zawadzki, J.V. & Jothianandan, D. (1984). Endothelial cells as mediators of vasodilation of arteries. J. Cardiovasc. Pharmacol. 6 Suppl 2, S336–S343.CrossRefPubMed
Galgano, F., Caruso, M., Condelli, N. & Favati, F. (2012). Focused review: agmatine in fermented foods. Front Microbiol. 3, 199.
Girault, J.A. & Greengard, P. (2004). The neurobiology of dopamine signaling. Arch. Neurol. 61, 641–644.CrossRefPubMed
Grady, S.L., Purdy, J.G., Rabinowitz, J.D. & Shenk, T. (2013). Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci U.S.A. 110, E5006–5015.CrossRef
Granadino, B., Beltran-Valero de, B.D., Fernandez-Canon, J.M., Penalva, M.A. & Rodriguez de, C.S. (1997). The human homogentisate 1, 2-dioxygenase (HGO) gene. Genomics. 43, 115–122.CrossRefPubMed
Gropman, A.L. (2012). Patterns of brain injury in inborn errors of metabolism. Semin. Pediatr. Neurol. 19, 203–210.CrossRef
Gross, U., Hoffmann, G.F. & Doss, M.O. (2000). Erythropoietic & hepatic porphyrias. J. Inherit. Metab Dis. 23, 641–661.
Gupta, V.K., et al. (2013). Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat. Neurosci. 16: 1453–1460.CrossRefPubMed
Hoeks, M.P., Heijer, M. den & Janssen, M.C. (2009). Adult issues in phenylketonuria. Neth J Med. 67, 2–7.PubMed
Hipkiss, A.R. (2009). Carnosine and its possible roles in nutrition and health. Adv Food Nutr Res. 57, 87–154.CrossRefPubMed
Humphrey, L.L., Fu, R., Rogers, K., Freeman, M. & Helfand, M. (2008). Homocysteine level & coronary heart disease incidence: a systematic review & meta-analysis. Mayo Clin. Proc. 83, 1203–1212.CrossRefPubMed
Ignarro, L.J. (2002). Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J. Physiol. Pharmacol. 53, 503–514.PubMed
Jaffe, E.K. & Stith, L. (2007). ALAD porphyria is a conformational disease. Am. J. Hum. Genet. 80, 329–337.CrossRefPubMed
Joseph, J. & Loscalzo, J. (2013). Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients. 5, 3235–3256.CrossRefPubMedPubMedCentral
Kamibayashi, T. & Maze, M. (2000). Clinical uses of alpha2 -adrenergic agonists. Anesthesiol. 93, 1345–1349.
Kips, J.C. & Pauwels, R.A. (2001). Long-acting inhaled beta(2)-agonist therapy in asthma. Am. J. Respir. Crit. Care Med. 164, 923–932.CrossRefPubMed
Kirk, J.M. (2008). Neonatal jaundice: a critical review of the role & practice of bilirubin analysis. Ann. Clin. Biochem. 45, 452–462.CrossRefPubMed
Knipp, S. & Bicker, G. (2009). Regulation of enteric neuron migration by the gaseous messenger molecules CO & NO. Development. 136, 85–93.CrossRefPubMed
Lawrence, S.H., Ramirez, U.D., Selwood, T., Stith, L. & Jaffe, E.K. (2009). Allosteric inhibition of human porphobilinogen synthase. J. Biol. Chem. 18, 35807–35817.CrossRef
Lesurtel, M., Graf, R., Aleil, B., Walther, D.J., Tian, Y., Jochum, W. et al. (2006). Platelet-derived serotonin mediates liver regeneration. Science. 312, 104–107.CrossRefPubMed
Litman, T., Søgaard, R. & Zeuthen, T. (2009). Ammonia and urea permeability of mammalian aquaporins. Handb Exp Pharmacol. 2009, 327–358.CrossRef
Liu, P.T. & Modlin, R.L. (2008). Human macrophage host defense against Mycobacterium tuberculosis. Curr. Opin. Immunol. 20, 371–376.CrossRefPubMed
Matsuda, M., Imaoka, T., Vomachka, A.J., Gudelsky, G.A., Hou, Z., Mistry, M. et al. (2004). Serotonin regulates mammary gland development via an autocrine-paracrine loop. Dev. Cell. 6, 193–203.
Mayer, M. (2000). Association of serum bilirubin concentration with risk of coronary artery disease. Clin. Chem. 46, 1723–1727.PubMed
McCully, K.S. (2007). Homocysteine, vitamins, & vascular disease prevention. Am. J. Clin. Nutr. 86, 1563S–1568S.CrossRefPubMed
McMurdy, J.W., Jay, G.D., Suner, S. & Crawford, G. (2008). Noninvasive optical, electrical, & acoustic methods of total hemoglobin determination. Clin. Chem. 54, 264–272.CrossRefPubMed
Mesa, J.L.M., Ruiz, J.R., Gonzalez-Gross, M.M., Sainz, A.G. & Garzon, M.J.C. (2002). Oral creatine supplementation & skeletal muscle metabolism in physical exercise. Sports Med. 32, 903–944.CrossRefPubMed
Missale, C., Nash, S.R., Robinson, S.W., Jaber, M. & Caron, M.G. (1998). Dopamine receptors: from structure to function. Physiol. Rev. 78, 189–225.CrossRefPubMed
Moinard, C. & Cynober, L. (2007). Citrulline: a new player in the control of nitrogen homeostasis. J. Nutr. 137, 1621S–1625S.CrossRefPubMed
Moini, M., Mistry, P. & Schilsky, M.L. (2010). Liver transplantation for inherited metabolic disorders of the liver. Curr Opin Organ Transplant. 15, 269–276.CrossRefPubMed
Moncada, S., Palmer, R.M. & Higgs, E.A. (1988). The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension. 12, 365–372.CrossRefPubMed
Norenberg, M.D., Rama Rao, K.V. & Jayakumar, A.R. (2009). Signaling factors in the mechanism of ammonia neurotoxicity. Metab. Brain Dis. 24, 103–117.CrossRefPubMed
Olsen, R.R. & Zetter, B.R. (2011). Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Mol Cancer Res. 9, 1285–1293.CrossRefPubMedPubMedCentral
Osowska, S., Moinard, C., Neveux, N., Loi, C. & Cynober, L. (2004). Citrulline increases arginine pools & restores nitrogen balance after massive intestinal resection. Gut. 53, 1781–1786.CrossRefPubMedPubMedCentral
Phillips, J.D., Jackson, L.K., Bunting, M., Franklin, M.R., Thomas, K.R., Levy, J.E. et al. (2001). A mouse model of familial porphyria cutanea tarda. Proc. Natl. Acad. Sci. U. S. A. 98, 259–264.CrossRefPubMed
Plaitakis, A., Zaganas, I. & Spanaki, C. (2013). Deregulation of glutamate dehydrogenase in human neurologic disorders. J Neurosci Res. 91, 1007–1017.CrossRefPubMed
Prasad, C. & Galbraith, P.A. (2005). Sir Archibald Garrod & alkaptonuria -’story of metabolic genetics’. Clin. Genet. 68, 199–203.CrossRefPubMed
Recchia, A., Debetto, P., Negro, A., Guidolin, D., Skaper, S.D. & Giusti, P. (2004). Alpha-synuclein & Parkinson’s disease. FASEB J. 18, 617–626.CrossRefPubMed
Rodrigo, R., Cauli, O., Boix, J., ElMlili, N., Agusti, A. & Felipo, V. (2009). Role of NMDA receptors in acute liver failure & ammonia toxicity: therapeutical implications. Neurochem. Int. 55, 113–118.CrossRefPubMed
Sassa, S. & Kappas, A. (2000). Molecular aspects of the inherited porphyrias. J. Intern. Med. 247, 169–178.CrossRefPubMed
Schousboe, A., Bak, L.K. & Waagepetersen, H.S. (2013). Astrocytic Control of Biosynthesis and turnover of the Neurotransmitters Glutamate and GABA. Front Endocrinol. 4, 102.
Schraenen, A., et al. (2010). Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy. Diabetologia 53, 2589–2599.CrossRefPubMedPubMedCentral
Seifert, R., Strasser, A., Schneider, E.H., Neumann, D., Dove, S. & Buschauer A. (2013). Molecular and cellular analysis of human histamine receptor subtypes. Trends Pharmacol Sci. 34, 33–58.CrossRefPubMed
Shintaku, H. (2002). Disorders of tetrahydrobiopterin metabolism & their treatment. Curr. Drug Metab. 3, 123–131.
Spanaki, C., Zaganas, I., Kleopa, K.A. & Plaitakis, A. (2010). Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells. J Biol. Chem. 285, 16748–16756.CrossRefPubMedPubMedCentral
Thurmond, R.L., Gelfand, E.W. & Dunford, P.J. (2008). The role of histamine H1 & H4 receptors in allergic inflammation: the search for new antihistamines. Nat. Rev. Drug Discov. 7, 41–53.CrossRefPubMed
Wagner, C. & Koury, M.J. (2007). S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine? Am. J. Clin. Nutr. 86, 1581–1585.CrossRefPubMed
Waldman, S.A. & Murad, F. (1988). Biochemical mechanisms underlying vascular smooth muscle relaxation: the guanylate cyclase-cyclic GMP system. J. Cardiovasc. Pharmacol. 12 Suppl 5, S115–S118.CrossRef
Walther, D.J., Peter, J.U., Bashammakh, S., Hortnagl, H., Voits, M., Fink, H. et al. (2003). Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 299, 76.CrossRefPubMed
Willert, E. & Phillips, M.A. (2012). Regulation and function of polyamines in African trypanosomes. Trends Parasitol. 28, 66–72.CrossRefPubMed
Woreta, T.A. & Alqahtani, SA. (2014). Evaluation of abnormal liver tests. Med Clin North Am. 98, 1–16.CrossRefPubMed
Yadav, V.K., Ryu, J.H., Suda, N., Tanaka, K.F., Gingrich, J.A., Schutz, G. et al. (2008). Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. 135, 825–837.CrossRefPubMedPubMedCentral
Zhou, L. & Zhu, D.Y. (2009). Neuronal nitric oxide synthase: structure, subcellular localization, regulation, & clinical implications. Nitric. Oxide. 20, 223–230.CrossRefPubMed
Metagegevens
Titel
Aminozuurmetabolisme
Auteur
Frans C. Schuit
Copyright
2015
Uitgeverij
Bohn Stafleu van Loghum
Boek
Leerboek metabolisme

Print ISBN: 978-90-368-0619-0

Elektronisch ISBN: 978-90-368-0620-6

Copyright: 2015

DOI
https://doi.org/10.1007/978-90-368-0620-6_9