Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander hoofdstuk

2022 | OriginalPaper | Hoofdstuk

10. Aandachtspunten bij farmacotherapie van de oudere patiënt

Auteur: Prof. dr. M. Petrovic

Gepubliceerd in: Geriatrie in de fysiotherapie en kinesitherapie

Uitgeverij: Bohn Stafleu van Loghum

share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

Het aantal tachtigplussers neemt toe, wat resulteert in een toenemend aantal mensen met multimorbiditeit. Multimorbiditeit creëert polyfarmacie, wat bijgevolg, de meest consistente voorspeller is van ongepast voorschrijven en geneesmiddelgerelateerde problemen (GRP’s) bij ouderen. In dit hoofdstuk worden de belangrijkste kenmerken van polyfarmacie en de risico’s op GRP’s beschreven in relatie tot fysieke inspanningen. Vervolgens worden de stappen beschreven die moeten worden overwogen bij het voorschrijven voor ouderen en worden methoden voor het opsporen van GRP’s en optimalisatie van polyfarmacie uitgewerkt.
Literatuur
1.
go back to reference Gnjidic D, Hilmer S, Blyth F, Naganathan V, Waite L, Seibel M, McLachlan A, Cumming R, Handelsman J, Le Couteur D. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65:989–95. CrossRef Gnjidic D, Hilmer S, Blyth F, Naganathan V, Waite L, Seibel M, McLachlan A, Cumming R, Handelsman J, Le Couteur D. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65:989–95. CrossRef
2.
go back to reference Kantor E, Rehm C, Haas J, Chan A, Giovannucci E. Trends in prescription drug use among older adults in United States from 1992–2012. JAMA. 2015;314:1818–31. CrossRef Kantor E, Rehm C, Haas J, Chan A, Giovannucci E. Trends in prescription drug use among older adults in United States from 1992–2012. JAMA. 2015;314:1818–31. CrossRef
3.
go back to reference Maust D, Gerlach L, Gibson A, Kales H, Blow F, Olfson M. Trends in central nervous system-active polypharmacy among older adults seen in outpatient care in the United States. JAMA Intern Med. 2017;177:583–5. CrossRef Maust D, Gerlach L, Gibson A, Kales H, Blow F, Olfson M. Trends in central nervous system-active polypharmacy among older adults seen in outpatient care in the United States. JAMA Intern Med. 2017;177:583–5. CrossRef
4.
go back to reference Gnjidic D, Hilmer S, Blyth F, Naganathan V, Cumming R, Handelsman D, McLachlan A, Abernethy D, Banks E, Le Couteur D. High risk prescribing and incidence of frailty among older community-dwelling men. Clin Pharmacol Ther. 2012;91:521–8. CrossRef Gnjidic D, Hilmer S, Blyth F, Naganathan V, Cumming R, Handelsman D, McLachlan A, Abernethy D, Banks E, Le Couteur D. High risk prescribing and incidence of frailty among older community-dwelling men. Clin Pharmacol Ther. 2012;91:521–8. CrossRef
5.
go back to reference Gallagher P, Lang P, Cherubini A, Topinková E, Cruz-Jentoft A, Montero-Errasquin B, Mádlová P, Gasperini B, Baeyens H, Baeyens J, Michel J, O’Mahony D. Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol. 2011;67:1175–88. CrossRef Gallagher P, Lang P, Cherubini A, Topinková E, Cruz-Jentoft A, Montero-Errasquin B, Mádlová P, Gasperini B, Baeyens H, Baeyens J, Michel J, O’Mahony D. Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol. 2011;67:1175–88. CrossRef
6.
go back to reference Kouladjian L, Gnjidic D, Chen T, Mangoni A, Hilmer S. Drug burden index in older adults: theoretical and practical issues. Clin Interv Aging. 2014;9:1503–15. CrossRef Kouladjian L, Gnjidic D, Chen T, Mangoni A, Hilmer S. Drug burden index in older adults: theoretical and practical issues. Clin Interv Aging. 2014;9:1503–15. CrossRef
7.
go back to reference Kashyap M, Belleville S, Mulsant B, Hilmer S, Paquette A, le Tu M, Tannenbaum C. Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. J Am Geriatr Soc. 2014;62:336–41. CrossRef Kashyap M, Belleville S, Mulsant B, Hilmer S, Paquette A, le Tu M, Tannenbaum C. Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. J Am Geriatr Soc. 2014;62:336–41. CrossRef
8.
go back to reference Fried T, O’Leary J, Towle V, Goldstein M, Trentalange M, Martin D. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014;62:2261–72. CrossRef Fried T, O’Leary J, Towle V, Goldstein M, Trentalange M, Martin D. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014;62:2261–72. CrossRef
9.
go back to reference Hilmer S, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85:86–8. CrossRef Hilmer S, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85:86–8. CrossRef
10.
go back to reference Saum K, Schöttker B, Meid A, Holleczek B, Haefeli W, Hauer K, Brenner H. Is polypharmacy associated with frailty in older people? Results from the ESTHER cohort study. J Am Geriatr Soc. 2017;65:e27-32. CrossRef Saum K, Schöttker B, Meid A, Holleczek B, Haefeli W, Hauer K, Brenner H. Is polypharmacy associated with frailty in older people? Results from the ESTHER cohort study. J Am Geriatr Soc. 2017;65:e27-32. CrossRef
11.
go back to reference Jamsen K, Bell J, Hilmer S, Kirkpatrick C, Ilomäki J, Le Couteur D, Blyth F, Handelsman D, Waite L, Naganathan V, Cumming R, Gnjidic D. Effects of changes in number of medications and drug burden index exposure on transitions between frailty states and death: the concord health and ageing in men project cohort study. J Am Geriatr Soc. 2016;64:89–95. CrossRef Jamsen K, Bell J, Hilmer S, Kirkpatrick C, Ilomäki J, Le Couteur D, Blyth F, Handelsman D, Waite L, Naganathan V, Cumming R, Gnjidic D. Effects of changes in number of medications and drug burden index exposure on transitions between frailty states and death: the concord health and ageing in men project cohort study. J Am Geriatr Soc. 2016;64:89–95. CrossRef
12.
go back to reference Farmer C, Fenu E, O’Flynn N, Guthrie B. Clinical assessment and management of multimorbidity: summary of NICE guidance. BMJ. 2016;354:i4843. Farmer C, Fenu E, O’Flynn N, Guthrie B. Clinical assessment and management of multimorbidity: summary of NICE guidance. BMJ. 2016;354:i4843.
13.
go back to reference Clarke C, Withal M. The effects of medication on activity and rehabilitation of older people- opportunities and risks. Rehabilitation Process and Outcome. 2017;6:1–7. CrossRef Clarke C, Withal M. The effects of medication on activity and rehabilitation of older people- opportunities and risks. Rehabilitation Process and Outcome. 2017;6:1–7. CrossRef
14.
go back to reference Reeve E, Gnjidic D, Long J, Himer S. A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice. Br J Clin Pharmacol. 2015;80:1254–68. CrossRef Reeve E, Gnjidic D, Long J, Himer S. A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice. Br J Clin Pharmacol. 2015;80:1254–68. CrossRef
15.
go back to reference Patterson S, Cadogan C, Kerse N, Cardwell C, Bradley M, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014;CD008165. Patterson S, Cadogan C, Kerse N, Cardwell C, Bradley M, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014;CD008165.
16.
go back to reference Hepler C, Strand L. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47:533–43. PubMed Hepler C, Strand L. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47:533–43. PubMed
17.
go back to reference Gallagher P, Barry P, O’Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32:113–21. CrossRef Gallagher P, Barry P, O’Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32:113–21. CrossRef
18.
go back to reference Spinewine A, Schmader KE, Barber N, Hughes C, Lapane K, Swine C, Hanlon J. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007;370:173–84. CrossRef Spinewine A, Schmader KE, Barber N, Hughes C, Lapane K, Swine C, Hanlon J. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007;370:173–84. CrossRef
20.
go back to reference Tommelein E, Mehuys E, Petrovic M, Somers A, Colin P, Boussery K. Potentially inappropriate prescribing in community-dwelling older people across Europe: a systematic literature review. Eur J Clin Pharmacol. 2015;71:1415–27. CrossRef Tommelein E, Mehuys E, Petrovic M, Somers A, Colin P, Boussery K. Potentially inappropriate prescribing in community-dwelling older people across Europe: a systematic literature review. Eur J Clin Pharmacol. 2015;71:1415–27. CrossRef
21.
go back to reference Al Hamid A, Ghaleb M, Aljadhey H, Aslanpour Z. A systematic review of hospitalization resulting from medicine-related problems in adult patients. Br J Clin Pharmacol. 2014;78:202–17. CrossRef Al Hamid A, Ghaleb M, Aljadhey H, Aslanpour Z. A systematic review of hospitalization resulting from medicine-related problems in adult patients. Br J Clin Pharmacol. 2014;78:202–17. CrossRef
22.
go back to reference Nivya K, Sri Sai Kiran V, Ragoo N, Jayaprakash B, Sonal Sekhar M. Systemic review on drug related hospital admissions – A PubMed based search. Saudi Pharm J. 2015;23:1–8. Nivya K, Sri Sai Kiran V, Ragoo N, Jayaprakash B, Sonal Sekhar M. Systemic review on drug related hospital admissions – A PubMed based search. Saudi Pharm J. 2015;23:1–8.
23.
go back to reference Van den Bemt P, Egberts A, Lenderink A, Verzijl J, Simons K, Van der Pol W, Leufkens H. Risk factors for the development of adverse drug events in hospitalized patients. Pharm World Sci. 2000;22:62–6. CrossRef Van den Bemt P, Egberts A, Lenderink A, Verzijl J, Simons K, Van der Pol W, Leufkens H. Risk factors for the development of adverse drug events in hospitalized patients. Pharm World Sci. 2000;22:62–6. CrossRef
24.
go back to reference Hajjar E, Hanlon J, Artz M, Lindblad C, Pieper C, Sloane R, Ruby C, Schmader K. Adverse drug reaction risk factors in older outpatients. Am J Geriatr Pharmacother. 2003;1:82–9. CrossRef Hajjar E, Hanlon J, Artz M, Lindblad C, Pieper C, Sloane R, Ruby C, Schmader K. Adverse drug reaction risk factors in older outpatients. Am J Geriatr Pharmacother. 2003;1:82–9. CrossRef
25.
go back to reference Field T, Gurwitz J, Avorn J, McCormick D, Jain S, Eckler M, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med. 2001;161:1629–34. CrossRef Field T, Gurwitz J, Avorn J, McCormick D, Jain S, Eckler M, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med. 2001;161:1629–34. CrossRef
26.
go back to reference Field T, Gurwitz J, Harrold L, Rothschild J, Debellis K, Seger A, et al. Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc. 2004;52:1349–54. CrossRef Field T, Gurwitz J, Harrold L, Rothschild J, Debellis K, Seger A, et al. Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc. 2004;52:1349–54. CrossRef
27.
go back to reference Lund B, Carnahan R, Egge J, Chrischilles E, Kaboli P. Inappropriate prescribing predicts adverse drug events in older adults. Ann Pharmacother. 2010;44:957–63. CrossRef Lund B, Carnahan R, Egge J, Chrischilles E, Kaboli P. Inappropriate prescribing predicts adverse drug events in older adults. Ann Pharmacother. 2010;44:957–63. CrossRef
28.
go back to reference Steinman M, Landefeld C, Rosenthal G, Berthenthal D, Sen S, Kaboli P. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54:1516–23. CrossRef Steinman M, Landefeld C, Rosenthal G, Berthenthal D, Sen S, Kaboli P. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54:1516–23. CrossRef
29.
go back to reference Page R, Linnebur S, Bryant L, Ruscin M. Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tools, and possible solutions. Clin Interv Aging. 2010;5:75–87. CrossRef Page R, Linnebur S, Bryant L, Ruscin M. Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tools, and possible solutions. Clin Interv Aging. 2010;5:75–87. CrossRef
30.
go back to reference Klotz U, Avant G, Hoyumpa A, Schenker S, Wilkinson G. The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest. 1975;55:347–59. CrossRef Klotz U, Avant G, Hoyumpa A, Schenker S, Wilkinson G. The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest. 1975;55:347–59. CrossRef
31.
go back to reference Wang L. Epidemiology and prevention of adverse drug reactions in the elderly. J Geriatr Cardiol. 2005;2:248–53. Wang L. Epidemiology and prevention of adverse drug reactions in the elderly. J Geriatr Cardiol. 2005;2:248–53.
32.
go back to reference Kinirons M, Crome P. Clinical pharmacokinetic considerations in the elderly. An update. Clin Pharmacokinet. 1997;33:302–12. CrossRef Kinirons M, Crome P. Clinical pharmacokinetic considerations in the elderly. An update. Clin Pharmacokinet. 1997;33:302–12. CrossRef
33.
go back to reference Kwan D, Farrell B. Polypharmacy: optimizing medication use in elderly patients. Can Geriatr J. 2014;4:21–7. Kwan D, Farrell B. Polypharmacy: optimizing medication use in elderly patients. Can Geriatr J. 2014;4:21–7.
34.
go back to reference Kolla BP, Lovely JK, Mansukhani MP, Morgenthaler TI. Zolpidem is independently associated with increased risk of inpatient falls. J Hosp Med. 2013;8(1–6):50. Kolla BP, Lovely JK, Mansukhani MP, Morgenthaler TI. Zolpidem is independently associated with increased risk of inpatient falls. J Hosp Med. 2013;8(1–6):50.
35.
go back to reference Nurminen J, Puustinen J, Lahteenmaki R, et al. Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics. BMC Geriatr. 2014;14:121. CrossRef Nurminen J, Puustinen J, Lahteenmaki R, et al. Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics. BMC Geriatr. 2014;14:121. CrossRef
36.
go back to reference Fox C, Smith T, Maidment I, et al. Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. Age Ageing. 2014;43:604–15. CrossRef Fox C, Smith T, Maidment I, et al. Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. Age Ageing. 2014;43:604–15. CrossRef
37.
go back to reference Mintzer J, Burns A. Anticholinergic side-effects of drugs in elderly people. J R Soc Med. 2000;93:457–62. CrossRef Mintzer J, Burns A. Anticholinergic side-effects of drugs in elderly people. J R Soc Med. 2000;93:457–62. CrossRef
38.
go back to reference Gnjidic D, Bell JS, Hilmer SN, Lönnroos E, Sulkava R, Hartikainen S. Drug burden index associated with function in community-dwelling older people in Finland: a cross-sectional study. Ann Med. 2012;44:458–67. CrossRef Gnjidic D, Bell JS, Hilmer SN, Lönnroos E, Sulkava R, Hartikainen S. Drug burden index associated with function in community-dwelling older people in Finland: a cross-sectional study. Ann Med. 2012;44:458–67. CrossRef
39.
go back to reference Salahudeen MS, Duffull SB, Nishtala PS. Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review. BMC Geriatr. 2015;15:31. CrossRef Salahudeen MS, Duffull SB, Nishtala PS. Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review. BMC Geriatr. 2015;15:31. CrossRef
40.
go back to reference Collamati A, Martone AM, Poscia A, et al. Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence. Aging Clin Exp Res. 2016;28:25–35. CrossRef Collamati A, Martone AM, Poscia A, et al. Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence. Aging Clin Exp Res. 2016;28:25–35. CrossRef
41.
go back to reference Rochon P, Gurwitz J. Optimising drug treatment for elderly people: the prescribing cascade. BMJ. 1997;315:1096–9. CrossRef Rochon P, Gurwitz J. Optimising drug treatment for elderly people: the prescribing cascade. BMJ. 1997;315:1096–9. CrossRef
44.
go back to reference Onder G, Van der Cammen TJ, Petrovic M, Somers A, Rajkumar C. Strategies to reduce the risk of iatrogenic illness in complex older adults. Age Ageing. 2013;42:284–91. CrossRef Onder G, Van der Cammen TJ, Petrovic M, Somers A, Rajkumar C. Strategies to reduce the risk of iatrogenic illness in complex older adults. Age Ageing. 2013;42:284–91. CrossRef
Metagegevens
Titel
Aandachtspunten bij farmacotherapie van de oudere patiënt
Auteur
Prof. dr. M. Petrovic
Copyright
2022
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-368-2783-6_10