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This study systematically examined the efficacy and safety of psychopharmacological and non-psychopharmacological treatments for anxiety in youth with autism spectrum disorders (ASD). Four psychopharmacological, nine cognitive behavioral therapy (CBT), and two alternative treatment studies met inclusion criteria. Psychopharmacological studies were descriptive or open label, sometimes did not specify the anxiety phenotype, and reported behavioral activation. Citalopram and buspirone yielded some improvement, whereas fluvoxamine did not. Non-psychopharmacological studies were mainly randomized controlled trials (RCTs) with CBT demonstrating moderate efficacy for anxiety disorders in youth with high functioning ASD. Deep pressure and neurofeedback provided some benefit. All studies were short-term and included small sample sizes. Large scale and long term RCTs examining psychopharmacological and non-psychopharmacological treatments are sorely needed.
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American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: American Psychiatric Association.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
Birmaher, B., Brent, D. A., Chiappetta, L., Bridge, J., Monga, S., & Baugher, M. (1999). Psychometric properties of the screen for child anxiety related emotional disorders (SCARED): A replication study. Journal of the American Academy of Child and Adolescent Psychiatry, 38(10), 1230–1236. PubMedCrossRef
Centers for Disease Control and Prevention. (2012). Prevalence of autism spectrum disorders—Autism and developmental disabilities monitoring network, 14 sites, United States, 2008. MMWR Surveill Summ, 61(3), 1–19.
Evans, D. W., Canavera, K., Kleinpeter, F. L., Maccubbin, E., & Taga, K. (2005). The fears, phobias and anxieties of children with autism spectrum disorders and down syndrome: Comparisons with developmentally and chronologically age matched children. Child Psychiatry and Human Development, 36(1), 3–26. PubMedCrossRef
Farrugia, S., & Hudson, J. (2006). Anxiety in adolescents with Asperger syndrome: Negative thoughts, behavioral problems, and life interference. Focus on Autism and Other Developmental Disabilities, 21(1), 25–35. CrossRef
Gillott, A., Furniss, F., & Walter, A. (2001). Anxiety in high-functioning children with autism. Autism: The International Journal of Research and Practice, 5(3), 277–286. CrossRef
Guy, W. (1976). Clinical global impression scale. The ECDEU Assessment Manual for Psychopharmacology-Revised. Volume DHEW Publ no ADM, 76(338), 218–222.
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., et al. (2008). Rating quality of evidence and strength of recommendations: GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. British Medical Journal, 336(7650), 924. PubMedCentralPubMedCrossRef
Hsia, Y., Wong, A. Y., Murphy, D. G., Simonoff, E., Buitelaar, J. K., & Wong, I. C. (2014). Psychopharmacological prescriptions for people with autism spectrum disorder (ASD): A multinational study. Psychopharmacology, 231(6), 999–1009.
Jarusiewicz, B. (2002). Efficacy of neurofeedback for children in the autistic spectrum: A pilot study. Journal of Neurotherapy, 6(4), 39–49. CrossRef
Kim, J. A., Szatmari, P., Bryson, S. E., Streiner, D. L., & Wilson, F. J. (2000). The prevalence of anxiety and mood problems among children with autism and Asperger syndrome. Autism, 4(2), 117–132. CrossRef
King, B. H., Hollander, E., Sikich, L., McCracken, J. T., Scahill, L., Bregman, J. D., et al. (2009). Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: Citalopram ineffective in children with autism. Archives of General Psychiatry, 66(6), 583. PubMedCentralPubMedCrossRef
Lecavalier, L., Wood, J. J., Halladay, A. K., Jones, N. E., Aman, M. G., Cook, E. H., et al. (2013). Measuring anxiety as a treatment endpoint in youth with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(5), 1128–1143.
Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (2002). Autism diagnostic observation schedule. Los Angeles: Western Psychological Services.
MacNeil, B. M., Lopes, V. A., & Minnes, P. M. (2009). Anxiety in children and adolescents with autism spectrum disorders. Research in Autism Spectrum Disorders, 3(1), 1–21. CrossRef
March, J. S., Conners, C., Arnold, G., Epstein, J., Parker, J., Hinshaw, S., et al. (1999). The multidimensional anxiety scale for children (MASC): Confirmatory factor analysis in a pediatric ADHD sample. Journal of Attention Disorders, 3(2), 85–89. CrossRef
Martin, A., Scahill, L., & Kratochvil, C. (2010). Pediatric psychopharmacology (2nd ed.). Oxford: Oxford University Press. CrossRef
McNally, R. H., Lincoln, A. J., Brown, M. Z., & Chavira, D. A. (2013). The coping cat program for children with anxiety and autism spectrum disorder: A pilot randomized controlled trial. Journal of Autism and Developmental Disorders, 43(1), 57–67. CrossRef
Merikangas, K. R., He, J., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., et al. (2010). Lifetime prevalence of mental disorders in US adolescents: Results from the national comorbidity survey replication-adolescent supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry, 49(10), 980–989. PubMedCentralPubMedCrossRef
Moree, B. N., & Davis, T. E, I. I. I. (2010). Cognitive-behavioral therapy for anxiety in children diagnosed with autism spectrum disorders: Modification trends. Research in Autism Spectrum Disorders, 4(3), 346–354. CrossRef
Reaven, J. A., Blakeley-Smith, A., Nichols, S., Dasari, M., Flanigan, E., & Hepburn, S. (2009). Cognitive-behavioral group treatment for anxiety symptoms in children with high-functioning autism spectrum disorders a pilot study. Focus on Autism and Other Developmental Disabilities, 24(1), 27–37. CrossRef
Rudy, B. M., Lewin, A. B., & Storch, E. A. (2013). Managing anxiety comorbidity in youth with autism spectrum disorders. Neuropsychiatry, 3(4), 411–421. CrossRef
RUPP Anxiety Study Group. (2002). The pediatric anxiety rating scale (PARS): Development and psychometric properties. Journal of the American Academy of Child and Adolescent Psychiatry, 41(9), 1061–1069. CrossRef
Silverman, W., & Albano, A. (1996). Anxiety disorders interview schedule for children for DSM-IV: (Child and parent versions). San Antonio, TX: Psychological Corporation/Graywind.
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921. PubMedCrossRef
Sofronoff, K., Attwood, T., & Hinton, S. (2005). A randomised controlled trial of a CBT intervention for anxiety in children with asperger syndrome. Journal of Child Psychology and Psychiatry and Allied Disciplines, 46(11), 1152–1160. CrossRef
Storch, E. A., Arnold, E. B., Lewin, A. B., Nadeau, J. M., Jones, A. M., De Nadai, A. S., et al. (2013). The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: A randomized, controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 52(2), 132–142. PubMedCrossRef
Sukhodolsky, D. G., Scahill, L., Gadow, K. D., Arnold, L. E., Aman, M. G., McDougle, C. J., et al. (2008). Parent-rated anxiety symptoms in children with pervasive developmental disorders: Frequency and association with core autism symptoms and cognitive functioning. Journal of Abnormal Child Psychology, 36(1), 117. PubMedCrossRef
US Preventive Services Task Force Procedure Manual. AHRQ Publication No. 08-05118-EF, July 2008. http://www.uspreventiveservicestaskforce.org/uspstf08/methods/procmanual.htm.
White, S. W., Ollendick, T., Albano, A. M., Oswald, D., Johnson, C., Southam-Gerow, M., et al. (2013). Randomized controlled trial: Multimodal anxiety and social skill intervention for adolescents with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(2), 382–394. PubMedCentralPubMedCrossRef
- A Systematic Review of Treatments for Anxiety in Youth with Autism Spectrum Disorders
Roma A. Vasa
Laura M. Carroll
Alixandra A. Nozzolillo
Micah O. Mazurek
Amanda E. Bennett
Logan K. Wink
Maria Pilar Bernal
- Springer US