Swipe om te navigeren naar een ander artikel
Major depressive disorder (MDD) negatively impacts different aspects of an individual’s life leading to grave impairments in quality of life (QOL). We performed a detailed analysis of the interaction between depressive symptom severity, functioning, and QOL in outpatients with MDD in order to better understand QOL impairments in MDD.
This cross-sectional study was conducted with 319 consecutive outpatients seeking treatment for DSM-IV-diagnosed MDD at an urban hospital-based outpatient clinic from 2005 to 2008 as part of the Cedars-Sinai Psychiatric Treatment Outcome Registry, a prospective cohort study of clinical, functioning, and patient-reported QOL outcomes in psychiatric disorders using a measurement-based care model. This model utilizes the following measures: (a) Depressive symptom severity: Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR); (b) Functioning measures: Global Assessment of Functioning (GAF), Sheehan Disability Scale (SDS), Work and Social Adjustment Scale, and the Endicott Work Productivity Scale; and (c) Quality of Life measure: Quality of Life, Enjoyment, and Satisfaction Questionnaire—Short Form (Q-LES-Q).
QOL is significantly impaired in MDD, with a mean Q-LES-Q score for this study population of 39.8 % (SD = 16.9), whereas the community norm average is 78.3 %. Regression modeling suggested that depressive symptom severity, functioning/disability, and age all significantly contributed to QOL. QIDS-SR (measuring depressive symptom severity), GAF, and SDS (measuring functioning/disability) scores accounted for 48.1, 17.4, and 13.3 % (semi-partial correlation values) of the variance in Q-LES-Q, respectively.
Our results show that impairment of QOL increases in a monotonic fashion with depressive symptom severity; however, depression symptom severity only accounted for 48.1 % of the QOL variance in our patient population. Furthermore, QOL is uniquely associated with measures of Functioning. We believe these results demonstrate the need to utilize not only Symptom Severity scales, but also Functioning and Quality of Life measures in MDD assessment, treatment, and research.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Constitution of the World Health Organization. (1946). American Journal of Public Health and the Nation’s Health, 36(11): 1315–1323.
Doraiswamy, P., Khan, Z. M., Donahue, J., & Richard, N. E. (2002). The spectrum of quality-of-life impairments in recurrent geriatric depression. Journal of Gerontology: Medical Sciences.,57A, M134–M137. CrossRef
Rush, A. J., & Trivedi, M. H. (1995). Treating depression to remission. Psychiatric Annals,25, 704–709.
Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl 20), 22–33; quiz 34–57.
Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., et al. (2003). The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): A psychometric evaluation in patients with chronic major depression. Biological Psychiatry,54(5), 585. CrossRef
American Psychiatric Association. (1994). Global Assessment of Functioning in diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Publishing Inc.
Sheehan, D. V. (1983). The anxiety disease. New York, NY: Scribner’s.
Endicott, J., Nee, J., Harrison, W., & Blumenthal, R. (1993). Quality of life enjoyment and satisfaction questionnaire: A new measure. Psychopharmacology Bulletin,29, 321–326. PubMed
Schechter, D., Endicott, J., Nee, J. (2007). Quality of life of ‘normal’ controls: Association with lifetime history of mental illness. Psychiatry Research, 30 152(1):45–54.
Beck, A. T., & Steer, R. A. (1990). Beck Anxiety Inventory manual. San Antonio, TX: Psychological Corporation.
Fleck, M., Simon, G., & Herrman, H. (2005). Major Depression and its correlates in primary care settings in six countries. British Journal of Psychiatry,186(1), 41–47. CrossRef
Daly, E. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Gaynes, B. N., Warden, D., et al. (2010). Health-related quality of life in depression: A STAR*D report. Annals of Clinical Psychiatry,22(1), 43–55. PubMed
Gureje, O., Kola, L., Afolabi, E., & Olley, B. O. (2008). Determinants of quality of life of elderly Nigerians: Results from the Ibadan study of ageing. African Journal of Medicine and Medical Sciences,37(3), 239–247. PubMed
Moore, M., Hofer, S., McGee, H., & Ring, L. (2005). Can the concept of depression and quality of life be integrated using a time perspective? Health and Quality of Life Outcomes,5, 3–11.
Ritsner, M. (2007). The distress/protection vulnerability model of quality of life impairment syndrome. In M. Ritsner & A. G. Awad (Eds.). Quality of life impairment in schizophrenia, mood, and anxiety disorders (pp. 3–19). The Netherlands: Springer.
- A descriptive analysis of quality of life using patient-reported measures in major depressive disorder in a naturalistic outpatient setting
Waguih William IsHak
Jared Matt Greenberg
Mark Hyman Rapaport
- Springer Netherlands