Two cases of left-sided and concomitant right-sided endocarditis: potential pathways of spreading

An 80-year-old man with a history of hypertension, ischaemic cerebrovascular accident and bio-prosthetic aortic valve replacement because of symptomatic aortic stenosis two months before admission (sutureless Perceval Sorin) presented to the hospital with fever. On clinical examination the patient was not dyspnoeic; his blood pressure was 110/70 mmHg. The sternotomy scar appeared normal. On cardiac auscultation heart sounds were normal and a short grade II/VI ejection murmur was heard at the second intercostal space at the right side of the sternum. Pulmonary auscultation was normal and there was no peripheral oedema. No stigmata of endocarditis were seen. Electrocardiography showed a sinus rhythm of 92 beats/min, and a new first-degree AV block (PQ interval: 344 ms), with normal axis and QRS duration. Laboratory testing showed leucocytosis (19 × 10⁹/L), increased C-reactive protein (CRP) levels (100 mg/L), and pre-existent renal dysfunction with a creatinine level of 353 μmol/L and a calculated glomerular filtration rate of <15 mL/min. On chest X-ray, a pre-existent enlargement of the heart was seen with a normal aspect of the lungs. Blood cultures were positive for coagulase-negative staphylococcus. Transoesophageal echocardiography revealed an aortic root abscess adjacent to the anterior leaflet of the mitral valve (Fig. 1a), as well as a vegetation on the tricuspid valve (Fig. 1b) The patient was treated with intravenous rifampicin and vancomycin and an operation was performed because of clinical deterioration. During surgery, extensive abscess formation and widespread vegetation made complete reconstruction impossible. The infected bioprosthesis was replaced by a mechanical valve. The patient died from multi-organ failure the next day.

A 54-year-old man with no significant medical history and no intravenous drug use presented to our emergency department with complaints of peripheral oedema, dyspnoea, sweating and fever. On clinical examination the patient had tachypnoea. Blood pressure was 135/85 mmHg. On cardiac auscultation heart sounds were normal and he had no murmur. Pulmonary crackles were heard on both sides. Peripheral oedema was present. A splinter haemorrhage was seen under his left index fingernail. Janeway lesions were seen on the left index and middle fingers. Electrocardiography showed a sinus tachycardia of 138 beats/min, and no further abnormalities. Laboratory testing showed leucocytosis (13 × 10⁹/L), and an increased CRP level (262 mg/L). On chest X-ray, pulmonary oedema was seen. Blood cultures proved positive for Staphylococcus aureus. At transoesophageal echocardiography, vegetations were seen on the anterosuperior leaflet of the tricuspid valve and on the anterior leaflet of the mitral valve (Fig. 2a and b). The patient was admitted to the intensive care unit for artificial respiration and treated with a 6-week course of intravenous flucloxacillin (12 g/day). During the hospital stay, the patient also developed an arthritis of the sterno-clavicular joint, which was confirmed by a positron emission tomography-computed tomography scan. Because of development of this arthritis during antibiotic treatment, the antibiotic course was extended by 2 weeks of 6 g/day flucloxacillin i.v. The vegetations decreased in size and no significant valve regurgitation or intracardiac abscess developed. Antibiotic treatment was stopped and there was no relapse.