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Journal of Autism and Developmental Disorders

Gepubliceerd in:

11-06-2021 | Original Paper

Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder

Auteurs: William E. DeCoteau, Adam E. Fox

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2022

Abstract

Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety.

vorige artikel Symptom Severity, Internalized and Externalized Behavioral and Emotional Problems: Links with Parenting Stress in Mothers of Children Recently Diagnosed with Autism

volgende artikel Challenges and Growth: Lived Experience of Adolescents and Young Adults (AYA) with a Sibling with ASD

Acosta, J., Campolongo, M. A., Höcht, C., Depino, A. M., Golombek, D. A., & Agostino, P. V. (2018). Deficits in temporal processing in mice prenatally exposed to valproic acid. European Journal of Neuroscience, 47(6), 619–630.PubMedCrossRef

Allman, M. J. (2011). Deficits in temporal processing associated with autistic disorder. Frontiers in Integrative Neuroscience, 5, 2. https://doi.org/10.3389/fnint.2011.00002/fullCrossRefPubMedPubMedCentral

Allman, M. J., & Falter, C. M. (2015). Abnormal timing and time perception in autism spectrum disorder? A review of the evidence. In A. Vatakis & M. J. Allman (Eds.), Time distortions in mind (pp. 37–56). BRILL.

Allman, M. J., & Mareschal, D. (2016). Possible evolutionary and developmental mechanisms of mental time travel (and implications for autism). Current Opinion in Behavioral Sciences, 8, 220–225.PubMedPubMedCentralCrossRef

Allman, M. J., & Meck, W. H. (2012). Pathophysiological distortions in time perception and timed performance. Brain: A Journal of Neurology, 135(Pt 3), 656–677. https://doi.org/10.1093/brain/awr210CrossRef

Allman, M. J., DeLeon, I. G., & Wearden, J. H. (2011). Psychophysical assessment of timing in individuals with autism. American Journal on Intellectual and Developmental Disabilities, 116(2), 165–178. https://doi.org/10.1352/1944-7558-116.2.165CrossRefPubMedPubMedCentral

Allman, M. J., Teki, S., Griffiths, T. D., & Meck, W. H. (2014a). Properties of the internal clock: First- and second-order principles of subjective time. Annual Review of Psychology, 65(1), 743–771. https://doi.org/10.1146/annurev-psych-010213-115117CrossRefPubMed

Allman, M. J., Yin, B., & Meck, W. H. (2014b). Time in the psychopathological mind. In V. Arstila & D. Lloyd (Eds.), Subjective time: The philosophy, psychology, and neuroscience of temporality (pp. 637–654). American Psychological Association.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association.CrossRef

Anshu, K., Nair, A. K., Kumaresan, U. D., Kutty, B. M., Srinath, S., & Laxmi, T. R. (2017). Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder. Autism Research, 10(12), 1929–1944.PubMedCrossRef

Balci, F., Freestone, D., & Gallistel, C. R. (2009). Risk assessment in man and mouse. Proceedings of the National Academy of Sciences, 106(7), 2459–2463.CrossRef

Balci, F., Papachristos, E. B., Gallistel, C. R., Brunner, D., Gibson, J., & Shumyatsky, G. P. (2008). Interval timing in genetically modified mice: A simple paradigm. Genes, Brain and Behavior, 7(3), 373–384.CrossRef

Bambini-Junior, V., Zanatta, G., Flora Nunes, D. G., de Melo, M. G., Michels, M., Fontes-Dutra, M., et al. (2014). Resveratrol prevents social deficits in animal model of autism induced by valproic acid. Neuroscience Letters, 583, 176–181. https://doi.org/10.1016/j.neulet.2014.09.039CrossRefPubMed

Banji, D., Banji, O. J. F., Abbagoni, S., Hayath, S., Kambam, S., & Chiluka, V. L. (2011). Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals. Brain Research, 1410, 141–151. https://doi.org/10.1016/j.brainres.2011.06.063CrossRefPubMed

Bares, M., Apps, R., Avanzino, L., Breska, A., D’Angelo, E., Filip, P., et al. (2019). Consensus paper: Decoding the contributions of the cerebellum as a time machine from neurons to clinical applications. Cerebellum (london, England), 18(2), 266–286. https://doi.org/10.1007/s12311-018-0979-5CrossRef

Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind”? Cognition, 21(1), 37–46.PubMedCrossRef

Becker, E. B., & Stoodley, C. J. (2013). Autism spectrum disorder and the cerebellum. International Review of Neurobiology, 113, 1–34. https://doi.org/10.1016/B978-0-12-418700-9.00001-0CrossRefPubMed

Brumback, A. C., Ellwood, I. T., Kjaerby, C., Iafrati, J., Robinson, S., Lee, A. T., et al. (2018). Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. Molecular Psychiatry, 23(10), 2078–2089. https://doi.org/10.1038/mp.2017.213CrossRefPubMed

Buhusi, C. V., & Meck, W. H. (2005). What makes us tick? functional and neural mechanisms of interval timing. Nature Reviews. Neuroscience, 6(10), 755–765.PubMedCrossRef

Buonomano, D. V. (2014). Neural dynamics based timing in the subsecond to seconds range. Advances in Experimental Medicine and Biology, 829, 101–117. https://doi.org/10.1007/978-1-4939-1782-2_6CrossRefPubMed

Cassidy, S., Hannant, P., Tavassoli, T., Allison, C., Smith, P., & Baron-Cohen, S. (2016). Dyspraxia and autistic traits in adults with and without autism spectrum conditions. Molecular Autism, 7(1), 48.PubMedPubMedCentralCrossRef

Chadman, K. K., Fernandes, S., DiLiberto, E., & Feingold, R. (2019). Do animal models hold value in autism spectrum disorder (ASD) drug discovery? Expert Opinion on Drug Discovery, 14, 727.PubMedCrossRef

Chomiak, T., Turner, N., & Hu, B. (2013a). What we have learned about autism spectrum disorder from valproic acid. Pathology Research International, 2013, 712758–712768. https://doi.org/10.1155/2013/712758CrossRefPubMedPubMedCentral

Chomiak, T., Turner, N., & Bin, Hu. (2013b). What we have learned about autism spectrum disorder from valproic acid. Pathology Research International, 2013, 712758–712768. https://doi.org/10.1155/2013/712758CrossRefPubMedPubMedCentral

Christensen, D. L., Maenner, M. J., Bilder, D., Constantino, J. N., Daniels, J., Durkin, M. S., et al. (2019). Prevalence and characteristics of autism spectrum disorder among children aged 4 years—Early autism and developmental disabilities monitoring network, seven sites, United States, 2010, 2012, and 2014. Morbidity and Mortality Weekly Report. Surveillance Summaries, 68(2), 1–19. https://doi.org/10.15585/mmwr.ss6802a1CrossRefPubMedPubMedCentral

Church, R. M., Meck, W. H., & Gibbon, J. (1994). Application of scalar timing theory to individual trials. Journal of Experimental Psychology: Animal Behavior Processes, 20, 135–155.PubMed

Clayton-Smith, J., & Donnai, D. (1995). Fetal valproate syndrome. Journal of Medical Genetics, 32(9), 724.PubMedPubMedCentralCrossRef

Coull, J. T., Cheng, R., & Meck, W. H. (2011). Neuroanatomical and neurochemical substrates of timing. Neuropsychopharmacology, 36(1), 3–25. https://doi.org/10.1038/npp.2010.113CrossRefPubMed

Daniels, C. W., Fox, A. E., Kyonka, E. G., & Sanabria, F. (2015). Biasing temporal judgments in rats, pigeons, and humans. International Journal of Comparative Psychology. https://doi.org/10.46867/ijcp.2015.28.02.07CrossRef

Delehanty, A. D., Stronach, S., Guthrie, W., Slate, E., & Wetherby, A. M. (2018). Verbal and nonverbal outcomes of toddlers with and without autism spectrum disorder, language delay, and global developmental delay. Autism & Developmental Language Impairments, 3, 2396941518764764.CrossRef

Demetriou, E. A., Lampit, A., Quintana, D. S., Naismith, S. L., Song, Y., Pye, J. E., et al. (2018). Autism spectrum disorders: A meta-analysis of executive function. Molecular Psychiatry, 23(5), 1198.PubMedCrossRef

Di Martino, A., Kelly, C., Grzadzinski, R., Zuo, X. N., Mennes, M., Mairena, M. A., et al. (2011). Aberrant striatal functional connectivity in children with autism. Biological Psychiatry, 69(9), 847–856. https://doi.org/10.1016/j.biopsych.2010.10.029CrossRefPubMed

Dziuk, M. A., Larson, J. G., Apostu, A., Mahone, E. M., Denckla, M. B., & Mostofsky, S. H. (2007). Dyspraxia in autism: Association with motor, social, and communicative deficits. Developmental Medicine & Child Neurology, 49(10), 734–739.CrossRef

Edalatmanesh, M. A., Nikfarjam, H., Vafaee, F., & Moghadas, M. (2013). Increased hippocampal cell density and enhanced spatial memory in the valproic acid rat model of autism. Brain Research, 1526, 15–25.PubMedCrossRef

Ellenbroek, B. A., August, C., & Youn, J. (2016). Does prenatal valproate interact with a genetic reduction in the serotonin transporter? A rat study on anxiety and cognition. Frontiers in Neuroscience, 10, 424.PubMedPubMedCentralCrossRef

Emmons, E. B., De Corte, B. J., Kim, Y., Parker, K. L., Matell, M. S., & Narayanan, N. S. (2017). Rodent medial frontal control of temporal processing in the dorsomedial striatum. The Journal of Neuroscience, 37(36), 8718–8733. https://doi.org/10.1523/JNEUROSCI.1376-17.2017CrossRefPubMedPubMedCentral

Ergaz, Z., Weinstein-Fudim, L., & Ornoy, A. (2016). Genetic and non-genetic animal models for autism spectrum disorders (ASD). Reproductive Toxicology, 64, 116–140.PubMedCrossRef

Falter, C. M., Noreika, V., Wearden, J. H., & Bailey, A. J. (2012). More consistent, yet less sensitive: Interval timing in autism spectrum disorders. Quarterly Journal of Experimental Psychology, 65(11), 2093–2107. https://doi.org/10.1080/17470218.2012.690770CrossRef

Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., et al. (2012). Consensus paper: Pathological role of the cerebellum in autism. Cerebellum (london, England), 11(3), 777–807. https://doi.org/10.1007/s12311-012-0355-9CrossRef

Favre, M. R., Barkat, T. R., Lamendola, D., Khazen, G., Markram, H., & Markram, K. (2013). General developmental health in the VPA-rat model of autism. Frontiers in Behavioral Neuroscience, 7, 88. https://doi.org/10.3389/fnbeh.2013.00088/fullCrossRefPubMedPubMedCentral

Fontes-Dutra, M., Nunes, G. D., Santos-Terra, J., Souza-Nunes, W., Bauer-Negrini, G., Hirsch, M. M., et al. (2019). Abnormal empathy-like pro-social behaviour in the valproic acid model of autism spectrum disorder. Behavioural Brain Research, 364, 11–18.PubMedCrossRef

Fox, A. E., & Kyonka, E. G. E. (2013). Pigeon responding in fixed-interval and response-initiated fixed-interval schedules of reinforcement. Journal of the Experimental Analysis of Behavior, 100(2), 187–197. https://doi.org/10.1002/jeab.38CrossRefPubMed

Fox, A. E., & Kyonka, E. G. (2015). Timing in response-initiated fixed intervals. Journal of the Experimental Analysis of Behavior, 103(2), 375–392. https://doi.org/10.1002/jeab.120CrossRefPubMed

Fox, A. E., & Kyonka, E. G. E. (2016). Effects of signaling on temporal control of behavior in response-initiated fixed intervals. Journal of the Experimental Analysis of Behavior, 106, 210–224.PubMedCrossRef

Fox, A. E., Prue, K. E., & Kyonka, E. G. (2016). What is timed in a fixed-interval temporal bisection procedure? Learning & Behavior, 44(4), 366–377.CrossRef

Fox, A. E., Caramia, S. R., Haskell, M. M., Ramey, A. L., & Singha, D. (2017). Stimulus control in two rodent models of attention-deficit/hyperactivity disorder. Behavioural Processes, 135, 16–24.PubMedCrossRef

Fox, A. E., Visser, E. J., & Nicholson, A. M. (2019). Interventions aimed at changing impulsive choice in rats: Effects of immediate and relatively long delay to reward training. Behavioural Processes, 158, 126–136.PubMedCrossRef

Friedman, S. D., Shaw, D. W., Artru, A. A., Dawson, G., Petropoulos, H., & Dager, S. R. (2006). Gray and white matter brain chemistry in young children with autism. Archives of General Psychiatry, 63(7), 786–794.PubMedCrossRef

Fukuchi, M., Nii, T., Ishimaru, N., Minamino, A., Hara, D., Takasaki, I., et al. (2009). Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions. Neuroscience Research, 65(1), 35–43. https://doi.org/10.1016/j.neures.2009.05.002CrossRefPubMed

Gadad, B. S., Hewitson, L., Young, K. A., & German, D. C. (2013). Neuropathology and animal models of autism: Genetic and environmental factors. Autism Research and Treatment. https://doi.org/10.1155/2013/731935CrossRefPubMedPubMedCentral

Gao, J., Wu, H., Cao, Y., Liang, S., Sun, C., Wang, P., et al. (2016). Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. The Journal of Nutritional Biochemistry, 35, 87–95.PubMedCrossRef

Gogolla, N., Leblanc, J. J., Quast, K. B., Sudhof, T. C., Fagiolini, M., & Hensch, T. K. (2009). Common circuit defect of excitatory-inhibitory balance in mouse models of autism. Journal of Neurodevelopmental Disorders, 1(2), 172–181. https://doi.org/10.1007/s11689-009-9023-xCrossRefPubMedPubMedCentral

Guilhardi, P., & Church, R. M. (2005). Dynamics of temporal discrimination. Learning and Behavior, 33, 399–416.PubMedCrossRef

Habib, A., Harris, L., Pollick, F., & Melville, C. (2019). A meta-analysis of working memory in individuals with autism spectrum disorders. PLoS ONE, 14(4), e0216198.PubMedPubMedCentralCrossRef

Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Herborg Hansen, F., Saunders, C., et al. (2013). De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Molecular Psychiatry, 18(12), 1315–1323. https://doi.org/10.1038/mp.2013.102CrossRefPubMedPubMedCentral

Haznedar, M. M., Buchsbaum, M. S., Hazlett, E. A., LiCalzi, E. M., Cartwright, C., & Hollander, E. (2006). Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. The American Journal of Psychiatry, 163(7), 1252–1263.PubMedCrossRef

Heilbronner, S. R., & Meck, W. H. (2014). Dissociations between interval timing and intertemporal choice following administration of fluoxetine, cocaine, or methamphetamine. Behavioural Processes, 101, 123–134. https://doi.org/10.1016/j.beproc.2013.09.013CrossRefPubMed

Hertz-Picciotto, I., Schmidt, R. J., & Krakowiak, P. (2018). Understanding environmental contributions to autism: Causal concepts and the state of science. Autism Research, 11(4), 554–586.PubMedCrossRef

Isaksson, S., Salomäki, S., Tuominen, J., Arstila, V., Falter-Wagner, C. M., & Noreika, V. (2018). Is there a generalized timing impairment in autism spectrum disorders across time scales and paradigms? Journal of Psychiatric Research, 99, 111–121.PubMedCrossRef

Juybari, K. B., Sepehri, G., Meymandi, M. S., Shahrbabaki, S. S. V., Moslemizadeh, A., Saeedi, N., et al. (2020). Sex dependent alterations of resveratrol on social behaviors and nociceptive reactivity in VPA-induced autistic-like model in rats. Neurotoxicology and Teratology, 81, 106905.PubMedCrossRef

Kaiser, D. H. (2008). The proportion of fixed interval trials to probe trials affects acquisition of the peak procedure fixed interval timing task. Behavioural Processes, 77(1), 100–108.PubMedCrossRef

Kemper, T. L., & Bauman, M. (1998). Neuropathology of infantile autism. Journal of Neuropathology and Experimental Neurology, 57(7), 645–652. https://doi.org/10.1097/00005072-199807000-00001CrossRefPubMed

Kerr, D. M., Downey, L., Conboy, M., Finn, D. P., & Roche, M. (2013). Alterations in the endocannabinoid system in the rat valproic acid model of autism. Behavioural Brain Research, 249, 124–132. https://doi.org/10.1016/j.bbr.2013.04.043CrossRefPubMed

Kim, J. W., Seung, H., Kwon, K. J., Ko, M. J., Lee, E. J., Oh, H. A., et al. (2014). Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism. PLoS ONE, 9(8), e104927. https://doi.org/10.1371/journal.pone.0104927CrossRefPubMedPubMedCentral

Kim, K. C., Choi, C. S., Kim, J., Han, S., Cheong, J. H., Ryu, J. H., & Shin, C. Y. (2016). MeCP2 modulates sex differences in the postsynaptic development of the valproate animal model of autism. Molecular Neurobiology, 53(1), 40–56.PubMedCrossRef

Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Park, J. H., Kim, H. J., et al. (2013). Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder. Journal of Neurochemistry, 124(6), 832–843.PubMedCrossRef

Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Yang, S., Cheong, J. H., et al. (2011). The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats. Toxicology Letters, 201(2), 137–142. https://doi.org/10.1016/j.toxlet.2010.12.018CrossRefPubMed

Knopf, A. (2018). Autism rates increase slightly: CDC. The Brown University Child and Adolescent Behavior Letter, 34(6), 4–5.CrossRef

Kuo, H. Y., & Liu, F. C. (2017). Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder. FASEB Journal, 31(10), 4458–4471. https://doi.org/10.1096/fj.201700054RCrossRefPubMed

Lambrechts, A., Falter-Wagner, C. M., & van Wassenhove, V. (2018). Diminished neural resources allocation to time processing in autism spectrum disorders. NeuroImage: Clinical, 17, 124–136.CrossRef

Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C. M., et al. (2012). Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography. Cortex: A Journal Devoted to the Study of the Nervous System and Behavior, 48(2), 183–193. https://doi.org/10.1016/j.cortex.2011.05.018CrossRef

Lauber, E., Filice, F., & Schwaller, B. (2016). Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related circuits in the cortex and striatum of mice. Frontiers in Molecular Neuroscience, 9, 150. https://doi.org/10.3389/fnmol.2016.00150CrossRefPubMedPubMedCentral

Lawson, W. (2001). Understanding and working with the spectrum of autism: An insider’s view. Jessica Kingsley Publishers.

Leigh, J. P., & Du, J. (2015). Brief report: Forecasting the economic burden of autism in 2015 and 2025 in the united states. Journal of Autism and Developmental Disorders, 45(12), 4135–4139.PubMedCrossRef

Lewis, G. J., Shakeshaft, N. G., & Plomin, R. (2018). Face identity recognition and the social difficulties component of the autism-like phenotype: Evidence for phenotypic and genetic links. Journal of Autism and Developmental Disorders, 48(8), 2758–2765.PubMedPubMedCentralCrossRef

Mabunga, D. F. N., Gonzales, E. L. T., Kim, J., Kim, K. C., & Shin, C. Y. (2015). Exploring the validity of valproic acid animal model of autism. Experimental Neurobiology, 24(4), 285–300.PubMedPubMedCentralCrossRef

MacDonald, M., Lord, C., & Ulrich, D. A. (2014). Motor skills and calibrated autism severity in young children with autism spectrum disorder. Adapted Physical Activity Quarterly, 31(2), 95–105.PubMedCrossRef

Macdonald, C. J., Cheng, R., & Meck, W. H. (2012). Acquisition of “start” and “stop” response thresholds in peak-interval timing is differentially sensitive to protein synthesis inhibition in the dorsal and ventral striatum. Frontiers in Integrative Neuroscience, 6, 10.PubMedPubMedCentralCrossRef

Main, S. L., & Kulesza, R. J. (2017). Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia. Neuroscience, 340, 34–47.PubMedCrossRef

Malapani, C., Dubois, B., Rancurel, G., & Gibbon, J. (1998). Cerebellar dysfunctions of temporal processing in the seconds range in humans. NeuroReport, 9(17), 3907–3912.PubMedCrossRef

Marinho, V., Oliveira, T., Rocha, K., Ribeiro, J., Magalhaes, F., Bento, T., et al. (2018). The dopaminergic system dynamic in the time perception: A review of the evidence. The International Journal of Neuroscience, 128(3), 262–282. https://doi.org/10.1080/00207454.2017.1385614CrossRefPubMed

Markram, K., Rinaldi, T., La Mendola, D., Sandi, C., & Markram, H. (2008). Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology, 33(4), 901–912. https://doi.org/10.1038/sj.npp.1301453CrossRefPubMed

Martin, J. S., Poirier, M., & Bowler, D. M. (2010). Brief report: Impaired temporal reproduction performance in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders, 40(5), 640–646. https://doi.org/10.1007/s10803-009-0904-3CrossRefPubMed

Meck, W. H. (2006a). Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. Brain Research, 1109(1), 93–107.PubMedCrossRef

Meck, W. H. (2006b). Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition. Brain Research, 1108(1), 168–175.PubMedCrossRef

Moore, S. J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D. J., Montgomery, T., & Dean, J. (2000). A clinical study of 57 children with fetal anticonvulsant syndromes. Journal of Medical Genetics, 37(7), 489–497.PubMedPubMedCentralCrossRef

Motanis, H., Seay, M. J., & Buonomano, D. V. (2018). Short-term synaptic plasticity as a mechanism for sensory timing. Trends in Neurosciences, 41(10), 701–711.PubMedPubMedCentralCrossRef

Muller, C. L., Anacker, A. M. J., & Veenstra-Vanderweele, J. (2015). The serotonin system in autism spectrum disorder: From biomarker to animal models. Neuroscience, 321, 24–41. https://doi.org/10.1016/j.neuroscience.2015.11.010CrossRefPubMed

Mychasiuk, R., Richards, S., Nakahashi, A., Kolb, B., & Gibb, R. (2012). Effects of rat prenatal exposure to valproic acid on behaviour and neuro-anatomy. Developmental Neuroscience, 34(2–3), 268–276. https://doi.org/10.1159/000341786CrossRefPubMed

Narayanan, N. S., Land, B. B., Solder, J. E., Deisseroth, K., & DiLeone, R. J. (2012). Prefrontal D1 dopamine signaling is required for temporal control. Proceedings of the National Academy of Sciences of the United States of America, 109(50), 20726–20731. https://doi.org/10.1073/pnas.1211258109CrossRefPubMedPubMedCentral

Nelson, S. B., & Valakh, V. (2015). Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders. Neuron, 87(4), 684–698. https://doi.org/10.1016/j.neuron.2015.07.033CrossRefPubMedPubMedCentral

Olexova, L., Stefanik, P., & Krskova, L. (2016). Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats—An animal model of autism. Neuroscience Letters, 629, 9–14.PubMedCrossRef

Petter, E. A., Lusk, N. A., Hesslow, G., & Meck, W. H. (2016). Interactive roles of the cerebellum and striatum in sub-second and supra-second timing: Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing. Neuroscience and Biobehavioral Reviews, 71, 739–755.PubMedCrossRef

R Core Team. (2019). R: A language and environment for statistical computing. R Core Team.

Ranger, P., & Ellenbroek, B. A. (2016). Perinatal influences of valproate on brain and behaviour: An animal model for autism. Current Topics in Behavioral Neurosciences, 29, 363–386. https://doi.org/10.1007/7854_2015_404CrossRefPubMed

Reynard, J. (2011). The impact of environmental enrichment on neurogenesis in an animal model of autism Available from Dissertations & Theses Europe Full Text: Science & Technology. Retrieved from https://search.proquest.com/docview/1238010355

Rogge, N., & Janssen, J. (2019). The economic costs of autism spectrum disorder: A literature review. Journal of Autism and Developmental Disorders, 49, 2873.PubMedCrossRef

Rubenstein, J. L., & Merzenich, M. M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes, Brain, and Behavior, 2(5), 255–267.PubMedPubMedCentralCrossRef

Sathyanesan, A., Zhou, J., Scafidi, J., Heck, D. H., Sillitoe, R. V., & Gallo, V. (2019). Emerging connections between cerebellar development, behaviour and complex brain disorders. Nature Reviews. Neuroscience, 20(5), 298–313. https://doi.org/10.1038/s41583-019-0152-2CrossRefPubMedPubMedCentral

Schneider, T., & Przewlocki, R. (2005). Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism. Neuropsychopharmacology, 30(1), 80–89. https://doi.org/10.1038/sj.npp.1300518CrossRefPubMed

Schneider, T., Roman, A., Basta-Kaim, A., Kubera, M., Budziszewska, B., Schneider, K., & Przewłocki, R. (2008). Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. Psychoneuroendocrinology, 33(6), 728–740.PubMedCrossRef

Schneider, T., Turczak, J., & Przewlocki, R. (2006). Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: Issues for a therapeutic approach in autism. Neuropsychopharmacology, 31(1), 36–46. https://doi.org/10.1038/sj.npp.1300767CrossRefPubMed

Schuck, R. K., Flores, R. E., & Fung, L. K. (2019). Brief report: Sex/gender differences in symptomology and camouflaging in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders, 49(6), 2597–2604.PubMedPubMedCentralCrossRef

Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47(8), 921–929.CrossRef

Soares, S., Atallah, B. V., & Paton, J. J. (2016). Midbrain dopamine neurons control judgment of time. Science (new York, n.y.), 354(6317), 1273–1277.CrossRef

Stoodley, C. J. (2016). The cerebellum and neurodevelopmental disorders. Cerebellum (london, England), 15(1), 34–37. https://doi.org/10.1007/s12311-015-0715-3CrossRef

Tosun, T., Gür, E., & Balcı, F. (2016). Mice plan decision strategies based on previously learned time intervals, locations, and probabilities. Proceedings of the National Academy of Sciences, 113(3), 787–792. https://doi.org/10.1073/pnas.1518316113CrossRef

Underwood, J. F., Kendall, K. M., Berrett, J., Anney, R., Van Den Bree, M., & Hall, J. (2018). ASD diagnosis in adults: Phenotype and genotype findings from a clinically-derived cohort. bioRxiv, 215, 647.

Vogel, D., Falter-Wagner, C. M., Schoofs, T., Krämer, K., Kupke, C., & Vogeley, K. (2019). Interrupted time experience in autism spectrum disorder: Empirical evidence from content analysis. Journal of Autism and Developmental Disorders, 49(1), 22–33.PubMedCrossRef

Wang, R., Tan, J., Guo, J., Zheng, Y., Han, Q., So, K. F., et al. (2018). Aberrant development and synaptic transmission of cerebellar cortex in a VPA induced mouse autism model. Frontiers in Cellular Neuroscience, 12, 500. https://doi.org/10.3389/fncel.2018.00500CrossRefPubMedPubMedCentral

Warrier, V., & Baron-Cohen, S. (2018). Genetic contribution to ‘theory of mind’in adolescence. Scientific Reports, 8(1), 3465.PubMedPubMedCentralCrossRef

Williams, G., King, J., Cunningham, M., Stephan, M., Kerr, B., & Hersh, J. H. (2001). Fetal valproate syndrome and autism: Additional evidence of an association. Developmental Medicine and Child Neurology, 43(3), 202–206.PubMedCrossRef

Wilson, C. E., Murphy, C. M., McAlonan, G., Robertson, D. M., Spain, D., Hayward, H., et al. (2016). Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Autism, 20(7), 808–819.PubMedPubMedCentralCrossRef

Wiśniowiecka-Kowalnik, B., & Nowakowska, B. A. (2019). Genetics and epigenetics of autism spectrum disorder—Current evidence in the field. Journal of Applied Genetics, 60(1), 37–47.PubMedPubMedCentralCrossRef

Wittmann, M., Carter, O., Hasler, F., Cahn, B. R., Grimberg, U., Spring, P., et al. (2007). Effects of psilocybin on time perception and temporal control of behaviour in humans. Journal of Psychopharmacology (Oxford, England), 21(1), 50–64. https://doi.org/10.1177/0269881106065859CrossRef

Wu, H. F., Chen, Y. J., Chu, M. C., Hsu, Y. T., Lu, T. Y., Chen, I. T., et al. (2018). Deep brain stimulation modified autism-like deficits via the serotonin system in a valproic acid-induced rat model. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19092840CrossRefPubMedPubMedCentral

Young, M. E. (2017). Discounting: A practical guide to multilevel analysis of indifference data. Journal of the Experimental Analysis of Behavior, 108(1), 97–112.PubMedCrossRef

Titel: Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder
Auteurs: William E. DeCoteau
Adam E. Fox
Publicatiedatum: 11-06-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05129-y

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