Gepubliceerd in:

01-02-2013

The use of hybrid statistical models to chart the heterogeneity of internalizing problem behavior in child- and adolescent psychiatric patients

Auteurs: Mark Patrick Roeling, Gwen C. Dieleman, Jan van der Ende, Frank C. Verhulst, Danielle Posthuma, Danielle Posthuma, Tinca J.C. Polderman, Gitta H. Lubke

Gepubliceerd in: Tijdschrift voor Kindergeneeskunde | bijlage 1/2013

Extract

Good phenotyping becomes increasingly important for genetic studies, as differences on a phenotypic level might be caused by differences in genetic architecture. Unobserved heterogeneity has to be inferred from the data with latent variable models such as latent class analysis (LCA) or factor analysis (FA). The drawback of using these models separately is that it is unclear whether the symptomatology defines a continuous or categorical structure. …

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