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Journal of Psychopathology and Behavioral Assessment

30-11-2023

The Influence of Functional Impairment in a Network of Child and Adolescent Psychopathology Domains

Auteurs: Jala Rizeq, Christie L. Burton, Paul D. Arnold, Jennifer Crosbie

Gepubliceerd in: Journal of Psychopathology and Behavioral Assessment

Abstract

In this study, we examined the unique associations between functional impairment and different psychopathology domains across childhood and adolescence. We examined whether functional impairment’s associations with psychopathological domains can offer important insights to understanding direct and indirect pathways for the co-occurrence among mental health difficulties across childhood and adolescence. From the population-based study Spit for Science, we included 5163 participants between the ages of 6 and 18.97 years (Mean age = 9.98, SD = 2.89) with parent/self-rated quantitative measures of psychopathology. We used network estimation to examine the unique associations among ratings of functional impairment, inattention, hyperactivity, autism, obsessions and compulsions, depression, anxiety, and irritability, while accounting for age effects. Bootstrapped difference tests of edges (partial correlations between two domains in a network) and node (domains/variable within a network) influence on network connectivity were conducted. In addition to domain specific associations, functional impairment-irritability and functional impairment-depression ratings were two of the strongest connections in the network. Overall, functional impairment and depression ratings had some of the highest centrality indices, in terms of their strength and number of direct and indirect connections. Age effects varied in the network with the positive age-depressive ratings connection being the strongest. This study demonstrates the importance of examining associations among psychopathology domains together with functional impairment to delineate important direct and indirect pathways for co-occurrence. We offer data driven hypotheses for impairment-related pathways and suggest important targets for intervention that can be examined in clinical research to mitigate comorbidities.

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We ran sensitivity analysis using a sample without siblings, where we only retained data from the eldest sibling to ensure the largest age range possible and developmental representation. The sample included 3857 participants between the ages of 6 and 18.97 years (Mean age = 10.40, SD = 2.99). The overall structure of the network and centrality results were also very similar to results reported with the full sample (see Table S2 and Figure S1 supplementary material).

We estimated the network in girls and boys separately and tested its invariance. The results indicated that the networks were invariant (Network invariance test M = 0.14, p = .11) in girls and boys and thus have kept the analysis and our reporting at the level of the full sample. Further, we estimated separate networks for youth and parent report for the subsample of participants 13 years or older. The network invariance results indicated that the networks were invariant (Network invariance test M = 0.24, p = .55), and thus we keep the analysis and reporting at the level of the full sample.

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Titel: The Influence of Functional Impairment in a Network of Child and Adolescent Psychopathology Domains
Auteurs: Jala Rizeq
Christie L. Burton
Paul D. Arnold
Jennifer Crosbie
Publicatiedatum: 30-11-2023
Uitgeverij: Springer US
Gepubliceerd in: Journal of Psychopathology and Behavioral Assessment
Print ISSN: 0882-2689
Elektronisch ISSN: 1573-3505
DOI: https://doi.org/10.1007/s10862-023-10100-5

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