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07-02-2019 | Uitgave 6/2019

Quality of Life Research 6/2019

The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C

Tijdschrift:
Quality of Life Research > Uitgave 6/2019
Auteurs:
Diego Alves Vieira, Luciana Rodrigues da Cunha, Cliviany Borges da Silva, Maria Thereza Bastos Almeida, Adriana Dias Gomes, César Lúcio Lopes de Faria Jr., Rosângela Teixeira, Fernando Silva Neves, Gifone Aguiar Rocha, Fabrício Freire de Melo, Dulciene Maria de Magalhães Queiroz, Luciana Diniz Silva
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-019-02129-5) contains supplementary material, which is available to authorized users.

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Abstract

Purpose

Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, − 819C/T, and − 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients.

Methods

132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations.

Results

Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36—physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.

Conclusion

This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.

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Extra materiaal
Supplementary material 1 (DOC 402 KB)
11136_2019_2129_MOESM1_ESM.doc
Literatuur
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