Methods
We examined data from National Health and Nutrition Examination Survey (NHANES 2005–2010). We included adult patients with chronic hepatitis C (CH-C), chronic hepatitis B (CH-B), alcohol-related liver disease (ALD), and nonalcoholic fatty liver disease (NAFLD). Patient Health Questionnaire (PHQ-9) survey was used as a depression screener. Univariate and multivariate analyses were performed to determine independent variables associated with each type of CLD and depression.
Results
The cohort included 10,231 NHANES participants. After multivariate analysis, CH-C was independently associated with age (OR = 1.05, 95% CI: 1.03–1.07), male gender (OR = 1.88, 95% CI: 1.19–2.97), African American race/ethnicity (OR = 2.50, 95% CI:1.50–4.18), smoking (OR = 6.20, 95% CI: 1.62–23.68), injection drug use (OR = 52.86, 95% CI:32.87–85.03), and depression (OR = 2.87, 95% CI: 1.78–4.62). CH-B was independently associated with being non-Caucasian (for African Americans OR = 5.09, 95% CI: 2.41–10.76, for other races OR = 4.74, 95% CI: 2.32–9.70). ALD was independently associated with younger age (OR = 0.98, 95% CI: 0.96–0.99), male gender (OR = 1.53, 95% CI: 1.19–1.95), Mexican American race/ethnicity (OR = 2.63, 95% CI: 1.87–3.69), and moderate to heavy smoking (OR = 2.08, 95% CI: 1.46–2.96). Finally, presence of insulin resistance [OR = 2.65 95% CI: 1.98–3.55], diabetes [OR = 1.54 95% CI: 1.11–2.13], and Mexican American race/ethnicity [OR = 2.03(1.35–3.06)], were predictive of NAFLD.