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10-06-2021 | Brief Report

The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI)

Auteurs: Katharine K. Brieger, Kelly M. Bakulski, Celeste L. Pearce, Ana Baylin, John F. Dou, Jason I. Feinberg, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, M. Daniele Fallin, Rebecca J. Schmidt

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2022

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Abstract

We examined maternal prenatal vitamin use or supplemental folic acid intake during month one of pregnancy for association with autism spectrum disorder (ASD) in the Early Autism Risk Longitudinal Investigation, an enriched-risk pregnancy cohort. Total folic acid intake was calculated from monthly prenatal vitamins, multivitamins, and other supplement reports. Clinical assessments through age 3 years classified children as ASD (n = 38) or non-ASD (n = 153). In pregnancy month one, prenatal vitamin use (59.7%) was not significantly associated with odds of ASD (OR = 0.70, 95%CI 0.32, 1.53). Sample size was limited and residual confounding was possible. Given the estimated effect sizes in this and previous work, prenatal vitamin intake during early pregnancy could be a clinically useful preventative measure for ASD.
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Metagegevens
Titel
The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI)
Auteurs
Katharine K. Brieger
Kelly M. Bakulski
Celeste L. Pearce
Ana Baylin
John F. Dou
Jason I. Feinberg
Lisa A. Croen
Irva Hertz-Picciotto
Craig J. Newschaffer
M. Daniele Fallin
Rebecca J. Schmidt
Publicatiedatum
10-06-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-05110-9

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