Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

07-10-2020 | Original Paper

Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD)

Auteurs: Mehmet Fatih Ceylan, Selma Tural Hesapcioglu, Cansu Pınar Yavas, Almila Senat, Ozcan Erel

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2021

Abstract

Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4–17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts.

vorige artikel Associations Between Child Sleep Problem Severity and Maternal Well-Being in Children with Autism Spectrum Disorder

volgende artikel Correction to: Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear Cells in Autism Spectrum Disorder (ASD)

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.CrossRef

Bar-Or, D., Lau, E., & Winkler, J. V. (2000). A novel assay for cobalt-albumin binding and its potential as a marker for a myocardial ischemia-a preliminary report. The Journal of emergency medicine, 19(4), 311–315.CrossRef

Bjørklund, G., Meguid, N. A., El-Bana, M. A., et al. (2020). Oxidative stress in autism spectrum disorder. Molecular Neurobiology, 57(5), 2314–2332.CrossRef

Bradley, P. P., Priebat, D. A., Christensen, R. D., & Rothstein, G. (1982). Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. The Journal of Investigative Dermatology, 78(3), 206–209.CrossRef

Ceylan, M. F., Sener, S., Bayraktar, A. C., & Kavutcu, M. (2012). Changes in oxidative stress and cellular immunity serum markers in attention-deficit/hyperactivity disorder. Psychiatry and Clinical Neurosciences, 66(3), 220–226.CrossRef

Ceylan, M. F., Uneri, O. S., Guney, E., et al. (2014). Increased levels of serum neopterin in attention deficit/hyperactivity disorder (ADHD). Journal of Neuroimmunology, 273(1–2), 111–114.CrossRef

Chess, S. (1971). Autism in children with congenital rubella. Journal of autism and childhood schizophrenia, 1(1), 33–47.CrossRef

Christensen, D. L., Bilder, D. A., Zahorodny, W., Pettygrove, S., Durkin, M. S., Fitzgerald, R. T., et al. (2016). Prevalence and characteristics of autism spectrum disorder among 4-Year-old children in the autism and developmental disabilities monitoring network. Journal of Developmental and Behavioral Pediatrics: JDBP, 37(1), 1–8.CrossRef

Cline, M. J. (1978). Monocytes, macrophages, and their diseases in man. The Journal of Investigative Dermatology, 71(1), 56–58.CrossRef

Delion, S., Chalon, S., Hérault, J., Guilloteau, D., Besnard, J. C., & Durand, G. (1994). Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. The Journal of Nutrition, 124(12), 2466–2476.CrossRef

Desmond, M. M., Montgomery, J. R., Melnick, J. L., Cochran, G. G., & Verniaud, W. (1969). Congenital rubella encephalitis. Effects on growth and early development. American Journal of Diseases of Children, 118(1), 30–31.CrossRef

Dogan, D., Ocal, N., Aydogan, M., Tasci, C., Arslan, Y., Tapan, S., et al. (2016). Assessment of the role of serum ischemia-modified albumin in obstructive sleep apnea in comparison with interleukin-6. Postgraduate Medicine, 128(6), 603–608.CrossRef

Ecker, C., Bookheimer, S. Y., & Murphy, D. G. (2015). Neuroimaging in autism spectrum disorder: Brain structure and function across the lifespan. The Lancet Neurology, 14(11), 1121–1134.CrossRef

Ellidag, H. Y., Bulbuller, N., Eren, E., et al. (2013). Ischemia-modified albumin: Could it be a new oxidative stress biomarker for colorectal carcinoma? Gut Liver, 7(6), 675–680.CrossRef

Goines, P. E., & Ashwood, P. (2013). Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment. Neurotoxicology and Teratology, 36, 67–81.CrossRef

Kim, Y. S., Leventhal, B. L., Koh, Y. J., Fombonne, E., Laska, E., Lim, E. C., et al. (2011). Prevalence of autism spectrum disorders in a total population sample. American Journal of Psychiatry, 168(9), 904–912.CrossRef

Kriisa, K., Haring, L., Vasar, E., et al. (2016). Antipsychotic treatment reduces indices of oxidative stress in first-episode psychosis patients. Oxidative Medicine and Cellular Longevity, 2016, 9616593.CrossRef

Matta, S. M., Hill-Yardin, E. L., & Crack, P. J. (2019). The influence of neuroinflammation in Autism Spectrum Disorder. Brain, behavior, and immunity.

Meltzer, A., & Van de Water, J. (2017). The role of the immune system in autism spectrum disorder. Neuropsychopharmacology, 42(1), 284–298.CrossRef

Mandic-Maravic, V., Pljesa-Ercegovac, M., Mitkovic-Voncina, M., et al. (2017). Impaired redox control in autism spectrum disorders: Could it be the X in GxE? Current Psychiatry Reports, 19(8), 52.CrossRef

Menezo, Y. J., Elder, K., & Dale, B. (2015). Link between increased prevalence of autism spectrum disorder syndromes and oxidative stress, DNA methylation, and imprinting: The impact of the environment. JAMA Pediatrics, 169(11), 1066–1067.CrossRef

Halliwell, B. (2006). Oxidative stress and neurodegeneration: Where are we now? Journal of Neurochemistry, 97(6), 1634–1658.CrossRef

Khan Amjad, A., Alsahli, M. A., & Rahmani, A. H. (2018). Myeloperoxidase as an active disease biomarker: Recent biochemical and pathological perspectives. Medical sciences. https://doi.org/10.3390/medsci6020033.CrossRefPubMedPubMedCentral

Nunez, E. A. (1993). Preface—fatty acids and cell signalling. Prostaglandins Leukot Essent Fatty Acids, 48(1), 1–4.CrossRef

Oberman, L. M., Ifert-Miller, F., Najib, U., Bashir, S., Gonzalez-Heydrich, J., Picker, J., et al. (2016). Abnormal mechanisms of plasticity and metaplasticity in autism spectrum disorders and fragile X syndrome. Journal of Child and Adolescent Psychopharmacology, 26(7), 617–624.CrossRef

Ohja, K., Gozal, E., Fahnestock, M., et al. (2018). Neuroimmunologic and neurotrophic interactions in autism spectrum disorders: Relationship to neuroinflammation. Neuromolecular Medicine, 20(2), 161–173.CrossRef

Pangrazzi, L., Balasco, L., & Bozzi, Y. (2020). Oxidative stress and immune system dysfunction in autism spectrum disorders. International Journal of Molecular Sciences, 21(9), 3293.CrossRef

Rossignol, D. A., & Frye, R. E. (2012). A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction, and environmental toxicant exposures. Molecular Psychiatry, 17(4), 389–401.CrossRef

Russo, A. J., Krigsman, A., Jepson, B., & Wakefield, A. (2009). Low serum myeloperoxidase in autistic children with gastrointestinal disease. Clinical and Experimental Gastroenterology, 2, 85.CrossRef

Schaefer, G. B., Mendelsohn, N. J., Practice, P., & Committee, G. (2013). Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: 2013 guideline revisions. Genetics in Medicine, 15(5), 399–407.CrossRef

Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of autism and developmental disorders.

Selek, S., Altindag, A., Saracoglu, G., & Aksoy, N. (2015). Oxidative markers of myeloperoxidase and catalase and their diagnostic performance in bipolar disorder. Journal of Affective Disorders, 181, 92–95.CrossRef

Sucuoglu, B., Oktem, F., & Gokler, B. (1996). Otistik cocukların degerlendirilmesinde kullanılan olceklere iliksin bir calısma. Psikiyatri Psikoloji Psikofarmakoloji, 4, 117–121.

Sweeten, T. L., Posey, D. J., & McDougle, C. J. (2003). High blood monocyte counts and neopterin levels in children with autistic disorder. American Journal of Psychiatry, 160(9), 1691–1693.CrossRef

Tordjman, S., Somogyi, E., Coulon, N., Kermarrec, S., Cohen, D., Bronsard, G., et al. (2014). Gene× environment interactions in autism spectrum disorders: role of epigenetic mechanisms. Frontiers in Psychiatry, 5, 53.CrossRef

Tunç, S., Atagün, M. İ., Neşelioğlu, S., Bilgin, Y. Y., Başbuğ, H. S., & Erel, Ö. (2019). Ischemia-modified albumin: A unique marker of global metabolic risk in schizophrenia and mood disorders. Psychiatry and Clinical Psychopharmacology, 29(2), 123–129.CrossRef

Tural Hesapcioglu, S., Kasak, M., Cıtak Kurt, A. N., & Ceylan, M. F. (2019). High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders. International Journal of Developmental Disabilities, 65(2), 73–81.CrossRef

Vaccarino, V., Brennan, M. L., Miller, A. H., Bremner, J. D., Ritchie, J. C., Lindau, F., et al. (2008). Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: A twin study. Biological Psychiatry, 64(6), 476–483.CrossRef

Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 57(1), 67–81.CrossRef

Volk, L., Chiu, S. L., Sharma, K., & Huganir, R. L. (2015). Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience, 38, 127–149.CrossRef

Waligora, A., Waligóra, S., Kozarska, M., Damasiewicz-Bodzek, A., Gorczyca, P., & Tyrpien-Golder, K. (2019). Autism spectrum disorder (ASD)-biomarkers of oxidative stress and methylation and transsulfuration cycle. Psychiatria polska, 53, 771–88.CrossRef

Yirmiya, R., & Goshen, I. (2011). Immune modulation of learning, memory, neural plasticity, and neurogenesis. Brain, Behavior, and Immunity, 25(2), 181–213.CrossRef

Zhang, R., Brennan, M. L., Shen, Z., MacPherson, J. C., Schmitt, D., Molenda, C. E., et al. (2002). Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. Journal of Biological Chemistry, 277(48), 46116–46122.CrossRef

Titel: Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear cells in Autism Spectrum Disorder (ASD)
Auteurs: Mehmet Fatih Ceylan
Selma Tural Hesapcioglu
Cansu Pınar Yavas
Almila Senat
Ozcan Erel
Publicatiedatum: 07-10-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04740-9

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 7/2021

Visual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study

Correction to: Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear Cells in Autism Spectrum Disorder (ASD)

From Syringe to Spoon Feeding: A Case Report of How Occupational Therapy Treatment Successfully Guided the Parents of a Child with Autism Spectrum Disorder and Prematurity in an Outpatient Clinic

Animal-Assisted Interventions for School-Aged Children with Autism Spectrum Disorder: A Meta-Analysis

A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders

Evaluating a Postsecondary Education Program for Students with Intellectual Disabilities: Leveraging the Parent Perspective