Swipe om te navigeren naar een ander artikel
The online version of this article (doi:10.1007/s11136-017-1610-9) contains supplementary material, which is available to authorized users.
Poor health-related quality of life (HRQOL) could lead to higher morbidity and mortality through telomere attrition or accelerated cellular aging. We conducted a cross-sectional analysis to examine the relationship between four dimensions of HRQOL and leukocyte telomere length (LTL) among a nationally representative sample of 3547 US adults (≥20 years) using the data from the 2001–2002 National Health and Nutrition Examination Survey.
We used HRQOL survey information collected on individuals’ self-rated general health, recent physical health, recent mental health, and recent activity limitation. Telomere length was assessed using quantitative polymerase chain reaction. Multiple linear regressions were used to estimate the relationship between each dimension of HRQOL and log-transformed values of LTL with adjustment for sample weights and design effects.
HRQOL-race interactions were significant, and the results were stratified by race. After controlling for demographic factors, disease conditions, and lifestyle variables, worse general health was significantly associated with shorter LTL for Blacks (coefficient, β: −0.022, 95% Confidence Interval, 95% CI: −0.03 to −0.01), but not for Whites or Mexican Americans. Unwell physical health was associated with shorter telomere length for Whites (β: −0.005, 95% CI: −0.01 to −0.001) only. Unwell mental health showed no significant association with LTL in any race.
Although longitudinal studies are needed to prove causality, our findings suggest that HRQOL could be associated with LTL shortening. We also found a possible racial difference in this association and recommend additional multiethnic studies to confirm this and to understand the reasons and consequences of this difference.
Supplementary material 1 (DOCX 62 kb)11136_2017_1610_MOESM1_ESM.docx
Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL) (1993). Qual Life Res, 2, 153–159.
Lopez Revuelta, K., Garcia Lopez, F. J., de Alvaro Moreno, F., et al. (2004). Perceived mental health at the start of dialysis as a predictor of morbidity and mortality in patients with end-stage renal disease (CALVIDIA Study). Nephrology Dialysis Transplantation, 19(9), 2347–2353. CrossRef
Tibblin, G., Svardsudd, K., Welin, L., et al. (1993). Quality of life as an outcome variable and a risk factor for total mortality and cardiovascular disease: a study of men born in 1913. Journal of Hypertension. Supplement, 11(4), S81–S86.
Willeit, P., Willeit, J., Brandstatter, A., et al. (2010). Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk. Arteriosclerosis Thrombosis and Vascular Biology, 30(8), 1649–1656. CrossRef
Carroll, J. E., Diez-Roux, A. V., Adler, N. E., et al. (2013). Socioeconomic factors and leukocyte telomere length in a multi-ethnic sample: findings from the multi-ethnic study of atherosclerosis (MESA). Brain Behavior and Immunity, 28, 108–114. CrossRef
Harris, S. E., Martin-Ruiz, C., von Zglinicki, T., et al. (2012). Telomere length and aging biomarkers in 70-year-olds: The Lothian Birth Cohort 1936. Neurobiology of Aging, 33(7), 30. CrossRef
Cohen, S., Janicki-Deverts, D., Turner, R. B., et al. (2013). Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection. Brain Behavior and Immunity, 34, 31–38. CrossRef
Prather, A. A., Gurfein, B., Moran, P., et al. (2015). Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women. Brain Behavior and Immunity, 47, 155–162. CrossRef
Adler, N., Pantell, M. S., O’Donovan, A., et al. (2013). Educational attainment and late life telomere length in the health, aging and body composition study. Brain Behavior and Immunity, 27(1), 15–21. CrossRef
Diaz, V. A., Mainous, A. G., Player, M. S., et al. (2010). Telomere length and adiposity in a racially diverse sample. Int J Obes, 34(2), 261–265. CrossRef
National Health and Nutrition Examination Survey analytic and reporting guidelines. 2004. National Center for Health Statistics Retrieved December 31, 2015, from http://www.cdc.gov/nchs/data/nhanes/nhanes_general_guidelines_june_04.pdf
Hagerty, M., Cummins, R., Ferriss, A., et al. (2001). Quality of life indexes for national policy: review and agenda for research. Social Indicators Research, 55(1), 1–96. CrossRef
Centers for Disease Control and Prevention. Health-related quality of life surveillance—United States, 1993–2002. In: Surveillance Summaries, October 28, 2005. MMWR 2005:54(No. SS-4).
National Health and Nutrition Examination Survey, 2001–2002 Data Documentation, Codebook, and Frequencies, Telomere Mean and Standard Deviation (Surplus) (TELO_B). (2014). National Health and Nutrition Examination Survey.
WHO (1995) Physical status: The use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854. Geneva: World Health Organization, 1995.
Perneger, T. V. (1998). What’s wrong with Bonferroni adjustments. Bmj, 316(7139), 1236–1238. PubMed
von Zglinicki, T., & Martin-Ruiz, C. M. (2005). Telomeres as biomarkers for ageing and age-related diseases. Current Molecular Medicine, 5(2), 197–203. CrossRef
O’Donovan, A., Pantell, M. S., Puterman, E., et al. (2011). Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS ONE, 6(5), 13.
von Zglinicki, T., Saretzki, G., Docke, W., et al. (1995). Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Experimental Cell Research, 220(1), 186–193. CrossRef
von Zglinicki, T. (2002). Oxidative stress shortens telomeres. Trends in Biochemical Sciences, 27(7), 339–344. CrossRef
Sargent-Cox, K. A., Anstey, K. J., & Luszcz, M. A. (2010). The choice of self-rated health measures matter when predicting mortality: Evidence from 10 years follow-up of the Australian longitudinal study of ageing. BMC Geriatrics, 10(1), 1–12. CrossRef
Angermeyer, M. C., & Dietrich, S. (2006). Public beliefs about and attitudes towards people with mental illness: A review of population studies. Acta Psychiatrica Scand., 113(3), 163–179. CrossRef
- Race-specific associations between health-related quality of life and cellular aging among adults in the United States: evidence from the National Health and Nutrition Examination Survey
Rumana J. Khan
Samson Y. Gebreab
Pia R. Crespo
Sharon K. Davis
- Springer International Publishing