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09-07-2016

Race-based medical mistrust, medication beliefs and HIV treatment adherence: test of a mediation model in people living with HIV/AIDS

Auteurs: Seth C. Kalichman, Lisa Eaton, Moira O. Kalichman, Tama Grebler, Cynthia Merely, Brandi Welles

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2016

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Abstract

Race-based medical mistrust significantly predicts non-adherence to antiretroviral therapy (ART) in people living with HIV. The current study builds on previous research that shows beliefs about medication necessity (i.e., “My medicines protect me from becoming worse”) and concerns (i.e., “Having to take my medicines worries me”) mediate the association between race-based medical mistrust and medication adherence. Racial and ethnic minority men and women living with HIV and receiving ART (N = 178) in a southern US city completed computerized measures of demographic and health characteristics, telephone interviews of race-based medical mistrust and medication beliefs, and unannounced phone-based pill counts for ART adherence. Multiple mediation modeling showed that medical mistrust is related to medication necessity and concerns beliefs and ART adherence. Furthermore, medication necessity beliefs predicted ART adherence. The indirect effect of medical mistrust on adherence through medication necessity beliefs was also significant. Results confirm that medication necessity beliefs, although not concerns beliefs, mediate the association between medical mistrust and ART adherence. Medication necessity beliefs offer a viable target for interventions to improve ART adherence in the context of mistrust that patients may have for medical providers and health care systems.
Literatuur
go back to reference Altice, F. L., Mostashari, F., & Friedland, G. H. (2001). Trust and the acceptance of and adherence to antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 28, 47–58.CrossRefPubMed Altice, F. L., Mostashari, F., & Friedland, G. H. (2001). Trust and the acceptance of and adherence to antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 28, 47–58.CrossRefPubMed
go back to reference Bangsberg, D., & Deeks, S. G. (2002). Is average adherence to HIV antiretroviral therapy enough? Jounal of General Internal Medicine, 17, 812–813.CrossRef Bangsberg, D., & Deeks, S. G. (2002). Is average adherence to HIV antiretroviral therapy enough? Jounal of General Internal Medicine, 17, 812–813.CrossRef
go back to reference Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182.CrossRefPubMed Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182.CrossRefPubMed
go back to reference Bogart, L. M., Wagner, G., Galvan, F. H., & Banks, D. (2010). Conspiracy beliefs about HIV are related to antiretroviral treatment nonadherence among african american men with HIV. Journal of Acquired Immune Deficiency Syndromes, 53, 648–655.PubMedPubMedCentral Bogart, L. M., Wagner, G., Galvan, F. H., & Banks, D. (2010). Conspiracy beliefs about HIV are related to antiretroviral treatment nonadherence among african american men with HIV. Journal of Acquired Immune Deficiency Syndromes, 53, 648–655.PubMedPubMedCentral
go back to reference Carrieri, M. P., Villes, V., et al. (2007). Self-reported side-effects of anti-retroviral treatment among IDUs: A 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8). International Journal of Drug Policy, 18, 288–295.CrossRefPubMed Carrieri, M. P., Villes, V., et al. (2007). Self-reported side-effects of anti-retroviral treatment among IDUs: A 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8). International Journal of Drug Policy, 18, 288–295.CrossRefPubMed
go back to reference Casagrande, S. S., Gary, T. L., LaVeist, T. A., Gaskin, D. J., & Cooper, L. A. (2007). Perceived discrimination and adherence to medical care in a racially integrated community. Journal of General Internal Medicine, 22, 389–395.CrossRefPubMedPubMedCentral Casagrande, S. S., Gary, T. L., LaVeist, T. A., Gaskin, D. J., & Cooper, L. A. (2007). Perceived discrimination and adherence to medical care in a racially integrated community. Journal of General Internal Medicine, 22, 389–395.CrossRefPubMedPubMedCentral
go back to reference Dale, S. K., Bogart, L. M., Wagner, G. J., Galvan, F. H., & Klein, D. J. (2014). Medical mistrust is related to lower longitudinal medication adherence among African-American males with HIV. Journal of Health Psychology, 21, 1311–1321.CrossRefPubMed Dale, S. K., Bogart, L. M., Wagner, G. J., Galvan, F. H., & Klein, D. J. (2014). Medical mistrust is related to lower longitudinal medication adherence among African-American males with HIV. Journal of Health Psychology, 21, 1311–1321.CrossRefPubMed
go back to reference Earl, T. R., Beach, M. C., Lombe, M., Korthuis, P. T., Sharp, V. L., Cohn, J. A., & Saha, S. (2013). Race, relationships and trust in providers among black patients with HIV/AIDS. Social Work Research, 37, 219–226.CrossRefPubMedPubMedCentral Earl, T. R., Beach, M. C., Lombe, M., Korthuis, P. T., Sharp, V. L., Cohn, J. A., & Saha, S. (2013). Race, relationships and trust in providers among black patients with HIV/AIDS. Social Work Research, 37, 219–226.CrossRefPubMedPubMedCentral
go back to reference Fredericksen, R., Feldman, B. J., Brown, T., Schmidt, S., Crane, P. K., Harrington, R. D., & Crane, H. M. (2014). Unannounced telephone-based pill counts: A valid and feasible method for monitoring adherence. AIDS and Behavior, 18, 2265–2273.CrossRefPubMedPubMedCentral Fredericksen, R., Feldman, B. J., Brown, T., Schmidt, S., Crane, P. K., Harrington, R. D., & Crane, H. M. (2014). Unannounced telephone-based pill counts: A valid and feasible method for monitoring adherence. AIDS and Behavior, 18, 2265–2273.CrossRefPubMedPubMedCentral
go back to reference Gaston, G. B., & Alleyne-Green, B. (2013). The impact of African Americans’ beliefs about HIV medical care on treatment adherence: A systematic review and recommendations for interventions. AIDS and Behavior, 17, 31–40.CrossRefPubMed Gaston, G. B., & Alleyne-Green, B. (2013). The impact of African Americans’ beliefs about HIV medical care on treatment adherence: A systematic review and recommendations for interventions. AIDS and Behavior, 17, 31–40.CrossRefPubMed
go back to reference Gonzalez, J. S., Penedo, F. J., Llabre, M. M., Duran, R. E., Antoni, M. H., Schneiderman, N., & Horne, R. (2007). Physical symptoms, beliefs about medications, negative mood, and long-term HIV medication adherence. Annals of Behavioral Medicine, 34, 46–55.CrossRefPubMed Gonzalez, J. S., Penedo, F. J., Llabre, M. M., Duran, R. E., Antoni, M. H., Schneiderman, N., & Horne, R. (2007). Physical symptoms, beliefs about medications, negative mood, and long-term HIV medication adherence. Annals of Behavioral Medicine, 34, 46–55.CrossRefPubMed
go back to reference Haberer, J. E., Robbins, G. K., Ybarra, M., Monk, A., Ragland, K., Weiser, S. D., & Bangsberg, D. R. (2011). Real-time electronic adherence monitoring is feasible, comparable to unannounced pill counts, and acceptable. AIDS and Behavior, 16, 375–382.CrossRef Haberer, J. E., Robbins, G. K., Ybarra, M., Monk, A., Ragland, K., Weiser, S. D., & Bangsberg, D. R. (2011). Real-time electronic adherence monitoring is feasible, comparable to unannounced pill counts, and acceptable. AIDS and Behavior, 16, 375–382.CrossRef
go back to reference Horne, R. (1999). Patients’ beliefs about treatment: The hidden determinant of treatment outcome? Joural of Psychosomatic Research, 47, 491–495.CrossRef Horne, R. (1999). Patients’ beliefs about treatment: The hidden determinant of treatment outcome? Joural of Psychosomatic Research, 47, 491–495.CrossRef
go back to reference Horne, R., Cooper, V., Gellaitry, G., Date, H. L., & Fisher, M. (2007). Patients’ perceptions of highly active antiretroviral therapy in relation to treatment uptake and adherence: The utility of the necessity-concerns framework. Journal of Acquired Immune Deficiency Syndromes, 45, 334–341.PubMed Horne, R., Cooper, V., Gellaitry, G., Date, H. L., & Fisher, M. (2007). Patients’ perceptions of highly active antiretroviral therapy in relation to treatment uptake and adherence: The utility of the necessity-concerns framework. Journal of Acquired Immune Deficiency Syndromes, 45, 334–341.PubMed
go back to reference Jonsdottir, H., Friis, S., Horne, R., Pettersen, K. I., Reikvam, A., & Andreassen, O. A. (2009). Beliefs about medications: Measurement and relationship to adherence in patients with severe mental disorders. Acta Psychiatrica Scandavia, 119, 78–84.CrossRef Jonsdottir, H., Friis, S., Horne, R., Pettersen, K. I., Reikvam, A., & Andreassen, O. A. (2009). Beliefs about medications: Measurement and relationship to adherence in patients with severe mental disorders. Acta Psychiatrica Scandavia, 119, 78–84.CrossRef
go back to reference Kalichman, S., Amaral, C. M., Cherry, C., Flanagan, J. A., Pope, H., Eaton, L., & Schinazi, R. (2008). Monitoring Antiretroviral adherence by unannounced pill counts conducted by telephone: Reliability and criterion-related validity. HIV Clinical Trials, 9, 298–308.CrossRefPubMedPubMedCentral Kalichman, S., Amaral, C. M., Cherry, C., Flanagan, J. A., Pope, H., Eaton, L., & Schinazi, R. (2008). Monitoring Antiretroviral adherence by unannounced pill counts conducted by telephone: Reliability and criterion-related validity. HIV Clinical Trials, 9, 298–308.CrossRefPubMedPubMedCentral
go back to reference Kalichman, S. C., Amaral, C., Swetsze, C., Eaton, L., Kalichman, M. O., Cherry, C., & Schinazi, R. F. (2010). Monthly unannounced pill counts for monitoring HIV treatment adherence: Tests for self-monitoring and reactivity effects. HIV Clinical Trials, 11, 325–331.CrossRefPubMed Kalichman, S. C., Amaral, C., Swetsze, C., Eaton, L., Kalichman, M. O., Cherry, C., & Schinazi, R. F. (2010). Monthly unannounced pill counts for monitoring HIV treatment adherence: Tests for self-monitoring and reactivity effects. HIV Clinical Trials, 11, 325–331.CrossRefPubMed
go back to reference Kalichman, S., Eaton, L., Kalichman, M., & Cherry, C. (2015). Medication beliefs mediate the association between medical mistrst and antiretroviral adherence among African-Americans living with HIV. Journal of Health Psychology. doi:10.1177/1359105315600239. Kalichman, S., Eaton, L., Kalichman, M., & Cherry, C. (2015). Medication beliefs mediate the association between medical mistrst and antiretroviral adherence among African-Americans living with HIV. Journal of Health Psychology. doi:10.​1177/​1359105315600239​.
go back to reference Kalichman, S. C., Kalichman, M. O., Cherry, C., Swetzes, C., Amaral, C. M., White, D., & Eaton, L. (2011). Brief behavioral self-regulation counseling for HIV treatment adherence delivered by cell phone: An initial test of concept trial. AIDS Patient Care STDs, 25, 303–310.CrossRefPubMedPubMedCentral Kalichman, S. C., Kalichman, M. O., Cherry, C., Swetzes, C., Amaral, C. M., White, D., & Eaton, L. (2011). Brief behavioral self-regulation counseling for HIV treatment adherence delivered by cell phone: An initial test of concept trial. AIDS Patient Care STDs, 25, 303–310.CrossRefPubMedPubMedCentral
go back to reference Kalichman, S., Rompa, D., & Cage, M. (2000). Distinguishing between overlapping somatic symptoms of depression and HIV disease in people living with HIV–AIDS. Journal of Nervous and Mental Disicions, 188, 662–670.CrossRef Kalichman, S., Rompa, D., & Cage, M. (2000). Distinguishing between overlapping somatic symptoms of depression and HIV disease in people living with HIV–AIDS. Journal of Nervous and Mental Disicions, 188, 662–670.CrossRef
go back to reference Lima, V. D., Bangsberg, D. R., Harrigan, P. R., Deeks, S. G., Yip, B., Hogg, R. S., & Montaner, J. S. (2010). Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level. Journal of Acquired Immune Deficiency Syndromes, 55, 460–465.CrossRefPubMedPubMedCentral Lima, V. D., Bangsberg, D. R., Harrigan, P. R., Deeks, S. G., Yip, B., Hogg, R. S., & Montaner, J. S. (2010). Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level. Journal of Acquired Immune Deficiency Syndromes, 55, 460–465.CrossRefPubMedPubMedCentral
go back to reference Maulsby, C., Millett, G., Lindsey, K., Kelley, R., Johnson, K., Montoya, D., & Holtgrave, D. (2014). HIV among Black men who have sex with men (MSM) in the United States: A review of the literature. AIDS and Behavior, 18, 10–25.CrossRefPubMed Maulsby, C., Millett, G., Lindsey, K., Kelley, R., Johnson, K., Montoya, D., & Holtgrave, D. (2014). HIV among Black men who have sex with men (MSM) in the United States: A review of the literature. AIDS and Behavior, 18, 10–25.CrossRefPubMed
go back to reference McFall, A. M., Dowdy, D. W., Zelaya, C. E., Murphy, K., Wilson, T. E., Young, M. A., & Althoff, K. N. (2013). Understanding the disparity: Predictors of virologic failure in women using highly active antiretroviral therapy vary by race and/or ethnicity. Journal of Acquired Immune Deficiency Syndromes, 64, 289–298.CrossRefPubMed McFall, A. M., Dowdy, D. W., Zelaya, C. E., Murphy, K., Wilson, T. E., Young, M. A., & Althoff, K. N. (2013). Understanding the disparity: Predictors of virologic failure in women using highly active antiretroviral therapy vary by race and/or ethnicity. Journal of Acquired Immune Deficiency Syndromes, 64, 289–298.CrossRefPubMed
go back to reference Morrison-Beedy, D., Carey, M. P., & Tu, X. (2006). Accuracy of audio computer-assisted self-interviewing (ACASI) and self-administered questionnaires for the assessment of sexual behavior. AIDS and Behavior, 10, 541–552.CrossRefPubMedPubMedCentral Morrison-Beedy, D., Carey, M. P., & Tu, X. (2006). Accuracy of audio computer-assisted self-interviewing (ACASI) and self-administered questionnaires for the assessment of sexual behavior. AIDS and Behavior, 10, 541–552.CrossRefPubMedPubMedCentral
go back to reference Nozaki, I., Kuriyama, M., Manyepa, P., Zyambo, M. K., Kakimoto, K., & Barnighausen, T. (2013). False beliefs about ART effectiveness, side effects and the consequences of non-retention and non-adherence among ART patients in Livingstone, Zambia. AIDS and Behavior, 17, 122–126.CrossRefPubMed Nozaki, I., Kuriyama, M., Manyepa, P., Zyambo, M. K., Kakimoto, K., & Barnighausen, T. (2013). False beliefs about ART effectiveness, side effects and the consequences of non-retention and non-adherence among ART patients in Livingstone, Zambia. AIDS and Behavior, 17, 122–126.CrossRefPubMed
go back to reference Parienti, J. J., Barrail-Tran, A., Duval, X., Nembot, G., Descamps, D., Vigan, M., & Goujard, C. (2013). Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy in the ANRS 134-COPHAR 3 trial. Antimicrobial Agents and Chemotherapy, 57, 2265–2271.CrossRefPubMedPubMedCentral Parienti, J. J., Barrail-Tran, A., Duval, X., Nembot, G., Descamps, D., Vigan, M., & Goujard, C. (2013). Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy in the ANRS 134-COPHAR 3 trial. Antimicrobial Agents and Chemotherapy, 57, 2265–2271.CrossRefPubMedPubMedCentral
go back to reference Pellowski, J. A., Kalichman, S. C., & Finitsis, D. J. (2015). Reliability and validity of a single-item rating scale to monitor medication adherence for people living with HIV and lower health literacy. HIV Clinical Trials, 16, 1–9.CrossRefPubMed Pellowski, J. A., Kalichman, S. C., & Finitsis, D. J. (2015). Reliability and validity of a single-item rating scale to monitor medication adherence for people living with HIV and lower health literacy. HIV Clinical Trials, 16, 1–9.CrossRefPubMed
go back to reference Pellowski, J. A., Kalichman, S. C., Matthews, K. A., & Adler, N. (2013). A pandemic of the poor: Social disadvantage and the U.S. HIV epidemic. American Psychologist, 68, 197–209.CrossRefPubMedPubMedCentral Pellowski, J. A., Kalichman, S. C., Matthews, K. A., & Adler, N. (2013). A pandemic of the poor: Social disadvantage and the U.S. HIV epidemic. American Psychologist, 68, 197–209.CrossRefPubMedPubMedCentral
go back to reference Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. [Research Support, N.I.H., Extramural]. Behavior Research Methods, 40, 879–891.CrossRefPubMed Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. [Research Support, N.I.H., Extramural]. Behavior Research Methods, 40, 879–891.CrossRefPubMed
go back to reference Reynolds, N. R., Testa, M. A., Su, M., Chesney, M. A., Neidig, J. L., Frank, I., & Robbins, G. K. (2008). Telephone support to improve antiretroviral medication adherence: A multisite, randomized controlled trial. Journal of Acquired Immune Deficiency Syndromes, 47, 62–68.CrossRefPubMed Reynolds, N. R., Testa, M. A., Su, M., Chesney, M. A., Neidig, J. L., Frank, I., & Robbins, G. K. (2008). Telephone support to improve antiretroviral medication adherence: A multisite, randomized controlled trial. Journal of Acquired Immune Deficiency Syndromes, 47, 62–68.CrossRefPubMed
go back to reference Saha, S., Jacobs, E. A., Moore, R. D., & Beach, M. C. (2010). Trust in physicians and racial disparities in HIV care. AIDS Patient Care STDs, 24, 415–420.CrossRefPubMedPubMedCentral Saha, S., Jacobs, E. A., Moore, R. D., & Beach, M. C. (2010). Trust in physicians and racial disparities in HIV care. AIDS Patient Care STDs, 24, 415–420.CrossRefPubMedPubMedCentral
go back to reference Shelton, R. C., Winkel, G., Davis, S. N., Roberts, N., Valdimarsdottir, H., Hall, S. J., & Thompson, H. S. (2010). Validation of the group-based medical mistrust scale among urban black men. Journal of General Internal Medicine, 25, 549–555.CrossRefPubMedPubMedCentral Shelton, R. C., Winkel, G., Davis, S. N., Roberts, N., Valdimarsdottir, H., Hall, S. J., & Thompson, H. S. (2010). Validation of the group-based medical mistrust scale among urban black men. Journal of General Internal Medicine, 25, 549–555.CrossRefPubMedPubMedCentral
go back to reference Siddiqi, A. E., Hu, X., & Hall, H. I. (2015). Mortality among blacks or African Americans with HIV infection: United States, 2008–2012. Morbidity and Mortality Weekly Report, 64, 81–86.PubMed Siddiqi, A. E., Hu, X., & Hall, H. I. (2015). Mortality among blacks or African Americans with HIV infection: United States, 2008–2012. Morbidity and Mortality Weekly Report, 64, 81–86.PubMed
go back to reference Simoni, J. M., Huh, D., Wilson, I. B., Shen, J., Goggin, K., Reynolds, N. R., & Liu, H. (2012). Racial/ethnic disparities in ART adherence in the United States: Findings from the MACH14 study. Journal of Acquired Immune Deficiency Syndromes, 60, 466–472.CrossRefPubMedPubMedCentral Simoni, J. M., Huh, D., Wilson, I. B., Shen, J., Goggin, K., Reynolds, N. R., & Liu, H. (2012). Racial/ethnic disparities in ART adherence in the United States: Findings from the MACH14 study. Journal of Acquired Immune Deficiency Syndromes, 60, 466–472.CrossRefPubMedPubMedCentral
Metagegevens
Titel
Race-based medical mistrust, medication beliefs and HIV treatment adherence: test of a mediation model in people living with HIV/AIDS
Auteurs
Seth C. Kalichman
Lisa Eaton
Moira O. Kalichman
Tama Grebler
Cynthia Merely
Brandi Welles
Publicatiedatum
09-07-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 6/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-016-9767-1