Gepubliceerd in:

01-02-2013

Low functionality of plasma-derived MBL upon substitution in MBL-deficient patients possibly explained by interaction with C1-inh

Auteurs: Mischa Keizer, Nannette Brouwer, Angela Kamp, Gerard van Mierlo, Diana Wouters, Taco Kuijpers

Gepubliceerd in: Tijdschrift voor Kindergeneeskunde | bijlage 1/2013

Extract

The risk of infection and inflammation is increased in immunocompromised patients and this also holds true for pediatric oncology patients. Due to (chemo-)therapy-induced neutropaenia, these patients are more dependent on the non-cellular complement system as a defense against pathogens. Deficiency of the complement component MBL is associated with an increased risk of infections in these patients. Previous work has shown that administration of plasma-derived MBL (pdMBL) to these patients leads to normal MBL plasma levels. However, despite high MBL levels, complement activation was not completely restored. …

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