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Gepubliceerd in:

01-04-2010

Hypoalgesia associated with elevated resting blood pressure: evidence for endogenous opioid involvement

Auteurs: Stephen Bruehl, John W. Burns, Ok Y. Chung, Edward Magid, Melissa Chont, Wesley Gilliam, Justin Matsuura, Kristin Somar, James K. Goodlad, Kevin Stone, Heather Cairl

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2010

Abstract

This study used a placebo-controlled, between-subjects opioid blockade design to evaluate endogenous opioid involvement in the hypoalgesia associated with elevated resting blood pressure (BP) in 163 healthy individuals. Participants were randomly assigned to Drug condition (placebo, naltrexone) and Task Order (computerized maze task with harassment followed by an ischemic pain task or vice versa). Resting BP was assessed, followed by drug administration, and then the pain and maze tasks. A significant Drug × Systolic BP (SBP) interaction was observed on McGill Pain Questionnaire-Affective pain ratings (P < .01), indicating that BP-related hypoalgesia observed under placebo was absent under opioid blockade. A significant Gender × Drug × SBP × Task Order interaction was observed for VAS pain intensity (P < .02). Examination of simple effects comprising this interaction suggested that BP-related hypoalgesia occurred only in male participants who experienced the pain task in the absence of emotional arousal, and indicated that this hypoalgesia occurred under placebo but not under opioid-blockade. Results suggest that under some circumstance, BP-related hypoalgesia may have an endogenous opioid-mediated component in healthy individuals, particularly men.

vorige artikel An examination of psychosocial correlates of exercise tolerance in cardiac rehabilitation participants

volgende artikel Acknowledgment of Reviewers (January 1, 2009–December 31, 2009)

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Titel: Hypoalgesia associated with elevated resting blood pressure: evidence for endogenous opioid involvement
Auteurs: Stephen Bruehl
John W. Burns
Ok Y. Chung
Edward Magid
Melissa Chont
Wesley Gilliam
Justin Matsuura
Kristin Somar
James K. Goodlad
Kevin Stone
Heather Cairl
Publicatiedatum: 01-04-2010
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 2/2010
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-009-9241-4

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