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Journal of Autism and Developmental Disorders

Gepubliceerd in:

28-11-2022 | Original Paper

Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome

Auteurs: Walter E. Kaufmann, Melissa Raspa, Carla M. Bann, Julia M. Gable, Holly K. Harris, Dejan B. Budimirovic, Reymundo Lozano, FORWARD Consortium

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2024

Abstract

Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natural history study, to identify behavioral subtypes by latent class analysis. Input included co-occurring behavioral conditions, sleep and sensory problems, autistic behavior scales (SCQ, SRS-2), and the Aberrant Behavior Checklist revised for FXS (ABC_FX). A 5-class solution yielded the most clinically meaningful, pharmacotherapy independent behavioral groups with distinctive SCQ, SRS-2, and ABC_FX profiles, and adequate non-overlap (≥ 71%): “Mild” (31%), “Moderate without Social Impairment” (32%), “Moderate with Social Impairment” (7%), “Moderate with Disruptive Behavior” (20%), and “Severe” (9%). Our findings support FXS subtyping, for improving clinical management and therapeutic development.

vorige artikel Additive or Interactive Associations of Food Allergies with Glutathione S-Transferase Genes in Relation to ASD and ASD Severity in Jamaican Children

volgende artikel Emotion Dysregulation Mediates the Relationship Between Sensory Processing and Behavior Problems in Young Children with Autism Spectrum Disorder: A Preliminary Study

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Titel: Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome
Auteurs: Walter E. Kaufmann
Melissa Raspa
Carla M. Bann
Julia M. Gable
Holly K. Harris
Dejan B. Budimirovic
Reymundo Lozano
FORWARD Consortium
Publicatiedatum: 28-11-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2024
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05821-7

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