Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism
- 21-06-2022
- Original Paper
Gepubliceerd in:
- Auteurs
-
Miranda Zuniga-Kennedy
Miranda Zuniga-Kennedy
- Department of Psychiatry, Columbia University Medical Center, 10032, New York, USA
- New York State Psychiatric Institute, 10032, New York, USA
- Center for Autism and the Developing Brain, New York-Presbyterian Hospital, 10605, White Plains, USA
-
Micah Davoren
Micah Davoren
- Department of Psychiatry, Columbia University Medical Center, 10032, New York, USA
- New York State Psychiatric Institute, 10032, New York, USA
- Center for Autism and the Developing Brain, New York-Presbyterian Hospital, 10605, White Plains, USA
-
Lauren C. Shuffrey
Lauren C. Shuffrey
- Department of Psychiatry, Columbia University Medical Center, 10032, New York, USA
- New York State Psychiatric Institute, 10032, New York, USA
-
Ruth Ann Luna
Ruth Ann Luna
- Department of Pathology and Immunology, Baylor College of Medicine, 77030, Houston, USA
- Department of Pathology, Texas Children’s Microbiome Center, Texas Children’s Hospital, 77030, Houston, USA
-
Tor Savidge
Tor Savidge
- Department of Pathology and Immunology, Baylor College of Medicine, 77030, Houston, USA
- Department of Pathology, Texas Children’s Microbiome Center, Texas Children’s Hospital, 77030, Houston, USA
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Vinay Prasad
Vinay Prasad
- Division of Pathology, Nationwide Children’s Hospital, 43205, Columbus, USA
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George M. Anderson
George M. Anderson
- Departments of Child Psychiatry and Laboratory Medicine, Yale University School of Medicine, 06510, New Haven, USA
-
Jeremy Veenstra-VanderWeele
Corresponderende auteur Jeremy Veenstra-VanderWeele
- Department of Psychiatry, Columbia University Medical Center, 10032, New York, USA
- New York State Psychiatric Institute, 10032, New York, USA
- Center for Autism and the Developing Brain, New York-Presbyterian Hospital, 10605, White Plains, USA
- 10025, New York, USA
-
Kent C. Williams
Kent C. Williams
- Department of Pediatric Gastroenterology, Nationwide Children’s Hospital, 43205, Columbus, USA
- Gepubliceerd in
- Journal of Autism and Developmental Disorders | Uitgave 9/2022
Abstract
Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3–18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.
- Titel
- Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism
- Auteurs
-
Miranda Zuniga-Kennedy
Micah Davoren
Lauren C. Shuffrey
Ruth Ann Luna
Tor Savidge
Vinay Prasad
George M. Anderson
Jeremy Veenstra-VanderWeele
Kent C. Williams
- Publicatiedatum
- 21-06-2022
- Uitgeverij
- Springer US
- Gepubliceerd in
-
Journal of Autism and Developmental Disorders / Uitgave 9/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432 - DOI
- https://doi.org/10.1007/s10803-022-05597-w
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