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Journal of Autism and Developmental Disorders

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21-06-2022 | Original Paper

Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism

Auteurs: Miranda Zuniga-Kennedy, Micah Davoren, Lauren C. Shuffrey, Ruth Ann Luna, Tor Savidge, Vinay Prasad, George M. Anderson, Jeremy Veenstra-VanderWeele, Kent C. Williams

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2022

Abstract

Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3–18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.

vorige artikel Prevalence of Autism Spectrum Disorders in Adult Outpatient Psychiatry

volgende artikel Figure Disembedding: The Gottschaldt’s Hidden Figure Test in Children with Typical Development and Autism

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Titel: Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism
Auteurs: Miranda Zuniga-Kennedy
Micah Davoren
Lauren C. Shuffrey
Ruth Ann Luna
Tor Savidge
Vinay Prasad
George M. Anderson
Jeremy Veenstra-VanderWeele
Kent C. Williams
Publicatiedatum: 21-06-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05597-w

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