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Quality of Life Research

Gepubliceerd in:

25-01-2023

Impact of episodic and chronic vestibular disorders on health-related quality of life and functioning—results from the DizzyReg patient registry

Auteurs: Ralf Strobl, Saly Harajli, Doreen Huppert, Andreas Zwergal, Eva Grill

Gepubliceerd in: Quality of Life Research | Uitgave 6/2023

Abstract

Purpose

Vertigo and dizziness belong to the most frequent syndromes in the primary, secondary and tertiary setting and can be divided into vertigo with episodic or chronic persistent complaints. Episodic vertigo (EVS) is characterized by recurrent attacks of vertigo or dizziness with intermittent symptom-free periods, while chronic vertigo (CVS) presents with persistent vertigo. It is still not completely understood how EVS or CVS affect health-related quality of life (HRQoL) and functioning.

Methods

Data originates from the DizzyReg patient registry, an ongoing prospective clinical patient registry situated at tertiary clinic at the university hospital, Munich. HRQoL and functioning was measured by self-report. CVS and EVS was categorized after comprehensive neuro-otological work-up in line with the diagnostic guidelines. Association of CVS and EVS was assessed with multivariable linear regression models adjusting for potential risk factors and confounders.

Results

The study included 548 patients (57% female, mean age 51.35). Patients with EVS were significantly younger (48.5 vs. 59.6 years) and were more often female (60 vs. 49%). EVS patients reported significantly better functioning (42.1 vs. 47.8) and HRQoL (63.87 vs. 58.08) than CVS patients. The effect was stable after adjusting for potential confounders.

Conclusion

This is the first study to show worse HRQoL in patients with CVS compared to EVS. The results of the study underpin the experience from clinical practice that mobility and balance control are especially important for patients with CVS.

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Alleen toegankelijk voor geautoriseerde gebruikers

Neuhauser, H. K., Radtke, A., von Brevern, M., Lezius, F., Feldmann, M., & Lempert, T. (2008). Burden of dizziness and vertigo in the community. Archives of Internal Medicine, 168(19), 2118–2124.PubMedCrossRef

Mueller, M., Schuster, E., Strobl, R., & Grill, E. (2012). Identification of aspects of functioning, disability and health relevant to patients experiencing vertigo: A qualitative study using the international classification of functioning, disability and health. Health and Quality of Life Outcomes, 10, 75.PubMedPubMedCentralCrossRef

Bronstein, A. M., Golding, J. F., Gresty, M. A., Mandala, M., Nuti, D., Shetye, A., & Silove, Y. (2010). The social impact of dizziness in London and Siena. Journal of Neurology, 257(2), 183–190.PubMedCrossRef

Grill, E., Strupp, M., Muller, M., & Jahn, K. (2014). Health services utilization of patients with vertigo in primary care: A retrospective cohort study. Journal of Neurology, 261(8), 1492–1498.PubMedCrossRef

Best, C., Eckhardt-Henn, A., Tschan, R., & Dieterich, M. (2009). Psychiatric morbidity and comorbidity in different vestibular vertigo syndromes. Results of a prospective longitudinal study over one year. Journal of Neurology, 256(1), 58–65.PubMedCrossRef

Lahmann, C., Henningsen, P., Brandt, T., Strupp, M., Jahn, K., Dieterich, M., Eckhardt-Henn, A., Feuerecker, R., Dinkel, A., & Schmid, G. (2015). Psychiatric comorbidity and psychosocial impairment among patients with vertigo and dizziness. Journal of Neurology, Neurosurgery and Psychiatry, 86(3), 302–308.PubMedCrossRef

Schlick, C., Schniepp, R., Loidl, V., Wuehr, M., Hesselbarth, K., & Jahn, K. (2016). Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study. Journal of Vestibular Research, 25(5–6), 241–251.PubMedCrossRef

Ten Voorde, M., van der Zaag-Loonen, H. J., & van Leeuwen, R. B. (2012). Dizziness impairs health-related quality of life. Quality of Life Research, 21(6), 961–966.PubMedCrossRef

Bronstein, A. M., & Dieterich, M. (2019). Long-term clinical outcome in vestibular neuritis. Current Opinion in Neurology, 32(1), 174–180.PubMedCrossRef

10.

Strupp, M., Kim, J. S., Murofushi, T., Straumann, D., Jen, J. C., Rosengren, S. M., Della Santina, C. C., & Kingma, H. (2017). Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Barany Society. Journal of Vestibular Research, 27(4), 177–189.PubMedPubMedCentralCrossRef

11.

Sun, D. Q., Ward, B. K., Semenov, Y. R., Carey, J. P., & Della Santina, C. C. (2014). Bilateral vestibular deficiency: Quality of life and economic implications. JAMA Otolaryngology. Head & Neck Surgery, 140(6), 527–534.CrossRef

12.

Decker, J., Limburg, K., Henningsen, P., Lahmann, C., Brandt, T., & Dieterich, M. (2019). Intact vestibular function is relevant for anxiety related to vertigo. Journal of Neurology, 266(Suppl 1), 89–92.PubMedPubMedCentralCrossRef

13.

Brandt, T., Grill, E., Strupp, M., & Huppert, D. (2018). Susceptibility to fear of heights in bilateral vestibulopathy and other disorders of vertigo and balance. Frontiers in Neurology, 9, 406.PubMedPubMedCentralCrossRef

14.

Brandt, T., & Dieterich, M. (2020). “Excess anxiety” and “less anxiety”: Both depend on vestibular function. Current Opinion in Neurology, 33(1), 136–141.PubMedCrossRef

15.

Carrillo Munoz, R., Ballve Moreno, J. L., Villar Balboa, I., Rando Matos, Y., Cunillera Puertolas, O., Almeda Ortega, J., Rodero Perez, E., Monteverde Curto, X., Rubio Ripolles, C., Moreno Farres, N., Matos Mendez, A., Gomez Nova, J. C., Bardina Santos, M., Villarreal Minano, J. J., Pacheco Erazo, D. L., Hernandez Sanchez, A. M., Grupo de estudio del vertigo en atencion primaria F. (2019). Disability perceived by primary care patients with posterior canal benign paroxysmal positional vertigo. BMC Family Practice, 20(1), 156.PubMedPubMedCentralCrossRef

16.

Yardley, L., Dibb, B., & Osborne, G. (2003). Factors associated with quality of life in Meniere’s disease. Clinical Otolaryngology & Allied Sciences, 28(5), 436–441.CrossRef

17.

Obermann, M., Bock, E., Sabev, N., Lehmann, N., Weber, R., Gerwig, M., Frings, M., Arweiler-Harbeck, D., Lang, S., & Diener, H. C. (2015). Long-term outcome of vertigo and dizziness associated disorders following treatment in specialized tertiary care: The Dizziness and Vertigo Registry (DiVeR) Study. Journal of Neurology, 262(9), 2083–2091.PubMedCrossRef

18.

von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gotzsche, P. C., Vandenbroucke, J. P., & Initiative, S. (2007). The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Epidemiology, 18(6), 800–804.CrossRef

19.

Grill, E., Muller, T., Becker-Bense, S., Gurkov, R., Heinen, F., Huppert, D., Zwergal, A., & Strobl, R. (2017). DizzyReg: The prospective patient registry of the German center for vertigo and balance disorders. Journal of Neurology, 264(Suppl 1), 34–36.PubMedCrossRef

20.

Bisdorff, A., Von Brevern, M., Lempert, T., & Newman-Toker, D. E. (2009). Classification of vestibular symptoms: Towards an international classification of vestibular disorders. Journal of Vestibular Research, 19(1–2), 1–13.PubMedCrossRef

21.

Lempert, T., Olesen, J., Furman, J., Waterston, J., Seemungal, B., Carey, J., Bisdorff, A., Versino, M., Evers, S., & Newman-Toker, D. (2012). Vestibular migraine: Diagnostic criteria. Journal of Vestibular Research, 22(4), 167–172.PubMedCrossRef

22.

Lopez-Escamez, J. A., Carey, J., Chung, W. H., Goebel, J. A., Magnusson, M., Mandala, M., Newman-Toker, D. E., Strupp, M., Suzuki, M., Trabalzini, F., Bisdorff, A., Classification Committee of the Barany S, Japan Society for Equilibrium R, European Academy of O Neurotology, Equilibrium Committee of the American Academy of, O.H. Neck S, Korean Balance S. (2015). Diagnostic criteria for Meniere’s disease. Journal of Vestibular Research, 25(1), 1–7.PubMedCrossRef

23.

Strupp, M., Lopez-Escamez, J. A., Kim, J. S., Straumann, D., Jen, J. C., Carey, J., Bisdorff, A., & Brandt, T. (2016). Vestibular paroxysmia: Diagnostic criteria. Journal of Vestibular Research, 26(5–6), 409–415.PubMed

24.

Strupp, M., & Magnusson, M. (2015). Acute unilateral vestibulopathy. Neurologic Clinics, 33(3), 669–685.PubMedCrossRef

25.

Kurre, A., Bastiaenen, C. H., van Gool, C. J., Gloor-Juzi, T., de Bruin, E. D., & Straumann, D. (2010). Exploratory factor analysis of the Dizziness Handicap inventory (German version). BMC Ear Nose Throat Disord, 10, 3.PubMedPubMedCentralCrossRef

26.

Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16(3), 297–334.CrossRef

27.

The EuroQol Group. (1990). EuroQol–a new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy, 16(3), 199–208.CrossRef

28.

Greiner, W., Weijnen, T., Nieuwenhuizen, M., Oppe, S., Badia, X., Busschbach, J., Buxton, M., Dolan, P., Kind, P., Krabbe, P., Ohinmaa, A., Parkin, D., Roset, M., Sintonen, H., Tsuchiya, A., & de Charro, F. (2003). A single European currency for EQ-5D health states Results from a six-country study. The European Journal of Health Economics, 4(3), 222–231.PubMedCrossRef

29.

Staab, J. P., Eckhardt-Henn, A., Horii, A., Jacob, R., Strupp, M., Brandt, T., & Bronstein, A. (2017). Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the committee for the classification of vestibular disorders of the Barany society. Journal of Vestibular Research, 27(4), 191–208.PubMedPubMedCentralCrossRef

30.

Shrier, I., & Platt, R. W. (2008). Reducing bias through directed acyclic graphs. BMC Medical Research Methodology, 8, 70.PubMedPubMedCentralCrossRef

31.

Textor, J., van der Zander, B., Gilthorpe, M. S., Liskiewicz, M., & Ellison, G. T. (2016). Robust causal inference using directed acyclic graphs: The R package “dagitty.” International Journal of Epidemiology, 45(6), 1887–1894.PubMed

32.

Fox, J., & Monette, G. (1992). Generalized collinearity diagnostics. Journal of the American Statistical Association, 87(417), 178–183.CrossRef

33.

R Core Team. (2019). A language and environment for statistical computing. R Foundation for Statistical Computing.

34.

Mohwald, K., Hadzhikolev, H., Bardins, S., Becker-Bense, S., Brandt, T., Grill, E., Jahn, K., Dieterich, M., & Zwergal, A. (2020). Health-related quality of life and functional impairment in acute vestibular disorders. European Journal of Neurology, 27(10), 2089–2098.PubMedCrossRef

35.

Yip, C. W., & Strupp, M. (2018). The Dizziness Handicap Inventory does not correlate with vestibular function tests: A prospective study. Journal of Neurology, 265(5), 1210–1218.PubMedCrossRef

36.

Lucieer, F. M. P., Van Hecke, R., van Stiphout, L., Duijn, S., Perez-Fornos, A., Guinand, N., Van Rompaey, V., Kingma, H., Joore, M., & van de Berg, R. (2020). Bilateral vestibulopathy: Beyond imbalance and oscillopsia. Journal of Neurology, 267(Suppl 1), 241–255.PubMedPubMedCentralCrossRef

37.

Schniepp, R., Boerner, J. C., Decker, J., Jahn, K., Brandt, T., & Wuehr, M. (2018). Noisy vestibular stimulation improves vestibulospinal function in patients with bilateral vestibulopathy. Journal of Neurology, 265(Suppl 1), 57–62.PubMedCrossRef

38.

Schniepp, R., Wuehr, M., Neuhaeusser, M., Kamenova, M., Dimitriadis, K., Klopstock, T., Strupp, M., Brandt, T., & Jahn, K. (2012). Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure. Movement Disorders, 27(1), 125–131.PubMedCrossRef

39.

Bronstein, A. (2005). Visual symptoms and vertigo. Frontiers in Neuroscience, 23(3), 705–713.

40.

Dobbels, B., Mertens, G., Gilles, A., Claes, A., Moyaert, J., van de Berg, R., Van de Heyning, P., Vanderveken, O., & Van Rompaey, V. (2019). Cognitive Function in acquired bilateral vestibulopathy: A cross-sectional study on cognition, hearing, and vestibular loss. Frontiers in Neuroscience, 13, 340.PubMedPubMedCentralCrossRef

41.

Schoberl, F., Pradhan, C., Grosch, M., Brendel, M., Jostes, F., Obermaier, K., Sowa, C., Jahn, K., Bartenstein, P., Brandt, T., Dieterich, M., & Zwergal, A. (2021). Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space. Science and Reports, 11(1), 2695.CrossRef

42.

Dobbels, B., Lucieer, F., Mertens, G., Gilles, A., Moyaert, J., van de Heyning, P., Guinand, N., Perez Fornos, A., Herssens, N., Hallemans, A., Vereeck, L., Vanderveken, O., Van Rompaey, V., & van de Berg, R. (2020). Prospective cohort study on the predictors of fall risk in 119 patients with bilateral vestibulopathy. PLoS ONE, 15(3), e0228768.PubMedPubMedCentralCrossRef

43.

Huppert, D., Straumann, D., Magnusson, M., Pyykko, I., & Brandt, T. (2018). Dizziness in Europe: From licensed fitness to drive to licence without fitness to drive. Journal of Neurology, 265(Suppl 1), 9–17.PubMedCrossRef

44.

Hays, R. D., & Fayers, P. M. (2021). Overlap of depressive symptoms with health-related quality-of-life measures. PharmacoEconomics, 39(6), 627–630.PubMedCrossRef

45.

Kaplan, R. M., & Hays, R. D. (2022). Health-related quality of life measurement in public health. Annual Review of Public Health, 43, 355–373.PubMedCrossRef

46.

Bigal, M. E., Serrano, D., Reed, M., & Lipton, R. B. (2008). Chronic migraine in the population: Burden, diagnosis, and satisfaction with treatment. Neurology, 71(8), 559–566.PubMedCrossRef

47.

Blumenfeld, A. M., Varon, S. F., Wilcox, T. K., Buse, D. C., Kawata, A. K., Manack, A., Goadsby, P. J., & Lipton, R. B. (2011). Disability, HRQoL and resource use among chronic and episodic migraineurs: Results from the International Burden of Migraine Study (IBMS). Cephalalgia, 31(3), 301–315.PubMedCrossRef

48.

Buse, D., Manack, A., Serrano, D., Reed, M., Varon, S., Turkel, C., & Lipton, R. (2012). Headache impact of chronic and episodic migraine: Results from the American Migraine prevalence and prevention study. Headache, 52(1), 3–17.PubMedCrossRef

49.

Grochtdreis, T., Dams, J., Konig, H. H., & Konnopka, A. (2019). Health-related quality of life measured with the EQ-5D-5L: Estimation of normative index values based on a representative German population sample and value set. The European Journal of Health Economics, 20(6), 933–944.PubMedCrossRef

50.

Marten, O., & Greiner, W. (2021). EQ-5D-5L reference values for the German general elderly population. Health and Quality of Life Outcomes, 19(1), 76.PubMedPubMedCentralCrossRef

51.

Hall, C. D., Herdman, S. J., Whitney, S. L., Cass, S. P., Clendaniel, R. A., Fife, T. D., Furman, J. M., Getchius, T. S., Goebel, J. A., Shepard, N. T., & Woodhouse, S. N. (2016). Vestibular rehabilitation for peripheral vestibular hypofunction: An evidence-based clinical practice guideline: From the American physical therapy association neurology section. Journal of Neurologic Physical Therapy, 40(2), 124–155.PubMedPubMedCentralCrossRef

52.

McDonnell, M. N., & Hillier, S. L. (2015). Vestibular rehabilitation for unilateral peripheral vestibular dysfunction. Cochrane Database of Systematic Reviews, 1, CD005397.PubMed

53.

van Vugt, V. A., van der Wouden, J. C., Essery, R., Yardley, L., Twisk, J. W. R., van der Horst, H. E., & Maarsingh, O. R. (2019). Internet based vestibular rehabilitation with and without physiotherapy support for adults aged 50 and older with a chronic vestibular syndrome in general practice: Three armed randomised controlled trial. BMJ, 367, l5922.PubMedPubMedCentralCrossRef

54.

Alghadir, A. H., & Anwer, S. (2018). Effects of vestibular rehabilitation in the management of a vestibular migraine: A review. Frontiers in Neurology, 9, 440.PubMedPubMedCentralCrossRef

55.

van Esch, B. F., van der Scheer-Horst, E. S., van der Zaag-Loonen, H. J., Bruintjes, T. D., & van Benthem, P. P. (2017). The effect of vestibular rehabilitation in patients with Meniere’s disease. Otolaryngology Head and Neck Surgery, 156(3), 426–434.PubMedCrossRef

56.

Zwergal, A., Strupp, M., & Brandt, T. (2019). Advances in pharmacotherapy of vestibular and ocular motor disorders. Expert Opinion on Pharmacotherapy, 20(10), 1267–1276.PubMedCrossRef

Titel: Impact of episodic and chronic vestibular disorders on health-related quality of life and functioning—results from the DizzyReg patient registry
Auteurs: Ralf Strobl
Saly Harajli
Doreen Huppert
Andreas Zwergal
Eva Grill
Publicatiedatum: 25-01-2023
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 6/2023
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-023-03345-w

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