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Gepubliceerd in: Tijdschrift voor Kindergeneeskunde 5/2011

01-10-2011

Hersentumoren op kinderleeftijd

Auteurs: Dhr. drs. D. Molanus, Dhr.drs. D.G. van Vuurden, dhr. drs. S.E. Mir, dhr. prof.dr. G.J.L. Kaspers, Dhr. dr. R.J. Vermeulen, Mw. ir. C.M. Korbijn, Dhr. prof.dr. W.P. Vandertop

Gepubliceerd in: Tijdschrift voor Kindergeneeskunde | Uitgave 5/2011

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Samenvatting

Hersentumoren zijn na leukemie de meest voorkomende vormen van kinderkanker. De frequentste symptomen bij presentatie zijn hoofdpijn, misselijkheid en braken, een abnormaal looppatroon of coördinatiestoornissen, papiloedeem en epileptische insulten. Diagnostiek bestaat uit beeldvorming met MRI-scan en histologische classificatie. De meest voorkomende hersentumoren op de kinderleeftijd zijn astrocytomen – waaronder tractus opticusgliomen en diffuse ponsgliomen –, medulloblastomen, ependymomen en craniofaryngiomen. Afhankelijk van de diagnose bestaat de behandeling uit neurochirurgische resectie, (chemo)radiotherapie en/of chemotherapie. De vijfjaarsoverleving van kinderen met een hersentumor is in de afgelopen decennia verbeterd van 58 naar 74%. Helaas ontstaan in maar liefst 82% van de overlevenden late effecten van ziekte en behandeling. Ontwikkelingen op het gebied van classificatie en nieuwe behandelstrategieën moeten in de toekomst de prognose van deze kinderen verder verbeteren en late effecten verminderen.
Literatuur
1.
go back to reference Centraal Bureau voor de Statistiek. Doodsoorzaken; korte lijst (belangrijke doodsoorzaken), leeftijd, geslacht. 28-5-2009.www.cbs.nl. 1-7-2011. Centraal Bureau voor de Statistiek. Doodsoorzaken; korte lijst (belangrijke doodsoorzaken), leeftijd, geslacht. 28-5-2009.www.​cbs.​nl. 1-7-2011.
3.
go back to reference Central Brain Tumor Registry of the United States (CBTRUS). CBTRUS 2009 Statistical Report 2005–2006 (Years of Data Collected).www.cbtrus.org. 2011. Central Brain Tumor Registry of the United States (CBTRUS). CBTRUS 2009 Statistical Report 2005–2006 (Years of Data Collected).www.​cbtrus.​org. 2011.
4.
5.
go back to reference Kaatsch P, Steliarova-Foucher E, Crocetti E, et al. Time trends of cancer incidence in European children (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:1961–71.PubMedCrossRef Kaatsch P, Steliarova-Foucher E, Crocetti E, et al. Time trends of cancer incidence in European children (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:1961–71.PubMedCrossRef
7.
go back to reference Wilne S, Collier J, Kennedy C, et al. Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol. 2007;8:685–95.PubMedCrossRef Wilne S, Collier J, Kennedy C, et al. Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol. 2007;8:685–95.PubMedCrossRef
8.
go back to reference Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114: 97–109.PubMedCrossRef Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114: 97–109.PubMedCrossRef
9.
go back to reference Vezina LG. Imaging of central nervous system tumors in children: advances and limitations. J Child Neurol. 2008;23:1128–35.PubMedCrossRef Vezina LG. Imaging of central nervous system tumors in children: advances and limitations. J Child Neurol. 2008;23:1128–35.PubMedCrossRef
10.
go back to reference Brenner DJ, Hall EJ. Computed tomography – an increasing source of radiation exposure. N Engl J Med. 2007;357:2277–84.PubMedCrossRef Brenner DJ, Hall EJ. Computed tomography – an increasing source of radiation exposure. N Engl J Med. 2007;357:2277–84.PubMedCrossRef
11.
go back to reference Schaller BJ, Cornelius JF, Sandu N, Buchfelder M. Molecular imaging of brain tumors personal experience and review of the literature. Curr Mol Med. 2008;8:711–26.PubMedCrossRef Schaller BJ, Cornelius JF, Sandu N, Buchfelder M. Molecular imaging of brain tumors personal experience and review of the literature. Curr Mol Med. 2008;8:711–26.PubMedCrossRef
12.
go back to reference Rickert CH, Paulus W. Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst. 2001;17:503–11.PubMedCrossRef Rickert CH, Paulus W. Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst. 2001;17:503–11.PubMedCrossRef
13.
14.
go back to reference Qaddoumi I, Sultan I, Gajjar A. Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database. Cancer. 2009;115:5761–70.PubMedCrossRef Qaddoumi I, Sultan I, Gajjar A. Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database. Cancer. 2009;115:5761–70.PubMedCrossRef
15.
go back to reference Shamji MF, Benoit BG. Syndromic and sporadic pediatric optic pathway gliomas: review of clinical and histopathological differences and treatment implications. Neurosurg Focus. 2007;23:E3.PubMedCrossRef Shamji MF, Benoit BG. Syndromic and sporadic pediatric optic pathway gliomas: review of clinical and histopathological differences and treatment implications. Neurosurg Focus. 2007;23:E3.PubMedCrossRef
16.
go back to reference Binning MJ, Liu JK, Kestle JRW, et al. Optic pathway gliomas: a review. Neurosurg Focus. 2007;23:E2.PubMedCrossRef Binning MJ, Liu JK, Kestle JRW, et al. Optic pathway gliomas: a review. Neurosurg Focus. 2007;23:E2.PubMedCrossRef
17.
go back to reference Listernick R, Darling C, Greenwald M, et al. Optic pathway tumors in children: the effect of neurofibromatosis type 1 on clinical manifestations and natural history. J Pediatr. 1995;127:718–22.PubMedCrossRef Listernick R, Darling C, Greenwald M, et al. Optic pathway tumors in children: the effect of neurofibromatosis type 1 on clinical manifestations and natural history. J Pediatr. 1995;127:718–22.PubMedCrossRef
18.
go back to reference Broniscer A, Gajjar A. Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. Oncologist. 2004;9:197–206.PubMedCrossRef Broniscer A, Gajjar A. Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. Oncologist. 2004;9:197–206.PubMedCrossRef
19.
go back to reference Finlay JL, Zacharoulis S. The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historical – and futuristic – perspective. J Neurooncol. 2005;75:253–66.PubMedCrossRef Finlay JL, Zacharoulis S. The treatment of high grade gliomas and diffuse intrinsic pontine tumors of childhood and adolescence: a historical – and futuristic – perspective. J Neurooncol. 2005;75:253–66.PubMedCrossRef
20.
go back to reference Bucci MK, Maity A, Janss AJ, et al. Near complete surgical resection predicts a favorable outcome in pediatric patients with nonbrainstem, malignant gliomas: results from a single center in the magnetic resonance imaging era. Cancer. 2004;101:817–24.PubMedCrossRef Bucci MK, Maity A, Janss AJ, et al. Near complete surgical resection predicts a favorable outcome in pediatric patients with nonbrainstem, malignant gliomas: results from a single center in the magnetic resonance imaging era. Cancer. 2004;101:817–24.PubMedCrossRef
21.
go back to reference Choux M. Brainstem tumors. In: Choux M, ed. Pediatric neurosurgery. New York: Churchill Livingstone, 2000. p. 471–91. Choux M. Brainstem tumors. In: Choux M, ed. Pediatric neurosurgery. New York: Churchill Livingstone, 2000. p. 471–91.
22.
go back to reference Jansen MH, Schaafsma EJ, Vandertop WP, et al. Diagnostiek, behandeling en beloop van kinderen met diffuse en focale ponstumoren. Ned Tijdschr Oncologie. 2009;6:339–50. Jansen MH, Schaafsma EJ, Vandertop WP, et al. Diagnostiek, behandeling en beloop van kinderen met diffuse en focale ponstumoren. Ned Tijdschr Oncologie. 2009;6:339–50.
23.
go back to reference Hargrave D, Bartels U, Bouffet E. Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol. 2006;7:241–8.PubMedCrossRef Hargrave D, Bartels U, Bouffet E. Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol. 2006;7:241–8.PubMedCrossRef
24.
go back to reference Jansen MH, Vuurden DG van, Vandertop WP, Kaspers GJ. Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology. Cancer Treat Rev. 2011 Jul 15. [Epub ahead of print] Jansen MH, Vuurden DG van, Vandertop WP, Kaspers GJ. Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology. Cancer Treat Rev. 2011 Jul 15. [Epub ahead of print]
25.
go back to reference Robertson PL, Muraszko KM, Brunberg JA, et al. Pediatric midbrain tumors: a benign subgroup of brainstem gliomas. Pediatr Neurosurg. 1995;22:65–73.PubMedCrossRef Robertson PL, Muraszko KM, Brunberg JA, et al. Pediatric midbrain tumors: a benign subgroup of brainstem gliomas. Pediatr Neurosurg. 1995;22:65–73.PubMedCrossRef
26.
go back to reference Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children’s Cancer Group 921 randomized phase III study. J Clin Oncol. 1999;17:832–45.PubMed Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children’s Cancer Group 921 randomized phase III study. J Clin Oncol. 1999;17:832–45.PubMed
27.
go back to reference Merchant TE, Kun LE, Krasin MJ, et al. Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys. 2008;70:782–7.PubMedCrossRef Merchant TE, Kun LE, Krasin MJ, et al. Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys. 2008;70:782–7.PubMedCrossRef
28.
go back to reference Packer RJ, Gajjar A,Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average- risk medulloblastoma. J Clin Oncol. 2006; 24:4202–8.PubMedCrossRef Packer RJ, Gajjar A,Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average- risk medulloblastoma. J Clin Oncol. 2006; 24:4202–8.PubMedCrossRef
29.
go back to reference Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children’s Cancer Group Study. J Clin Oncol. 1999;17:2127–36.PubMed Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children’s Cancer Group Study. J Clin Oncol. 1999;17:2127–36.PubMed
30.
go back to reference von Hoff K, Hinkes B, Gerber NU, et al. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT’91. Eur J Cancer. 2009;45:1209–17.CrossRef von Hoff K, Hinkes B, Gerber NU, et al. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT’91. Eur J Cancer. 2009;45:1209–17.CrossRef
31.
go back to reference Rutkowski S, Gerber NU, von Hoff K, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy. Neuro Oncol. 2009;11:201–10.PubMedCrossRef Rutkowski S, Gerber NU, von Hoff K, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy. Neuro Oncol. 2009;11:201–10.PubMedCrossRef
32.
go back to reference MacDonald TJ, Rood BR, Santi MR, et al. Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors. Oncologist. 2003;8:174–86.PubMedCrossRef MacDonald TJ, Rood BR, Santi MR, et al. Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors. Oncologist. 2003;8:174–86.PubMedCrossRef
34.
go back to reference Smyth MD, Horn BN, Russo C, Berger MS. Intracranial ependymomas of childhood: current management strategies. Pediatr Neurosurg. 2000; 33:138–50.PubMedCrossRef Smyth MD, Horn BN, Russo C, Berger MS. Intracranial ependymomas of childhood: current management strategies. Pediatr Neurosurg. 2000; 33:138–50.PubMedCrossRef
35.
go back to reference Zacharoulis S, Ji L, Pollack IF, et al. Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors. Pediatr Blood Cancer. 2008;50:231–5.PubMedCrossRef Zacharoulis S, Ji L, Pollack IF, et al. Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors. Pediatr Blood Cancer. 2008;50:231–5.PubMedCrossRef
36.
go back to reference Agaoglu FY, Ayan I, Dizdar Y, et al. Ependymal tumors in childhood. Pediatr Blood Cancer. 2005;45:298–303.PubMedCrossRef Agaoglu FY, Ayan I, Dizdar Y, et al. Ependymal tumors in childhood. Pediatr Blood Cancer. 2005;45:298–303.PubMedCrossRef
37.
go back to reference Nejat F, El Khashab M, Rutka JT. Initial management of childhood brain tumors: neurosurgical considerations. J Child Neurol. 2008;23:1136–48.PubMedCrossRef Nejat F, El Khashab M, Rutka JT. Initial management of childhood brain tumors: neurosurgical considerations. J Child Neurol. 2008;23:1136–48.PubMedCrossRef
38.
go back to reference Sughrue ME, et al. Craniopharyngioma. In: Gupta N, Banerjee A, Haas-Kogan D, eds. Pediatric CNS tumors. Berlin: Springer, 2010. p. 135–58.CrossRef Sughrue ME, et al. Craniopharyngioma. In: Gupta N, Banerjee A, Haas-Kogan D, eds. Pediatric CNS tumors. Berlin: Springer, 2010. p. 135–58.CrossRef
39.
go back to reference Bunin GR, Surawicz TS, Witman PA, et al. The descriptive epidemiology of craniopharyngioma. J Neurosurg. 1998;89:547–51.PubMedCrossRef Bunin GR, Surawicz TS, Witman PA, et al. The descriptive epidemiology of craniopharyngioma. J Neurosurg. 1998;89:547–51.PubMedCrossRef
40.
go back to reference Peris-Bonet R, Martinez-Garcia C, Lacour B, et al. Childhood central nervous system tumours – incidence and survival in Europe (1978–1997): report from Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:2064–80.PubMedCrossRef Peris-Bonet R, Martinez-Garcia C, Lacour B, et al. Childhood central nervous system tumours – incidence and survival in Europe (1978–1997): report from Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:2064–80.PubMedCrossRef
41.
go back to reference Muller HL. Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm Res. 2008;69:193–202.PubMedCrossRef Muller HL. Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm Res. 2008;69:193–202.PubMedCrossRef
42.
go back to reference Ohmori K, Collins J, Fukushima T. Craniopharyngiomas in children. Pediatr Neurosurg. 2007;43:265–78.PubMedCrossRef Ohmori K, Collins J, Fukushima T. Craniopharyngiomas in children. Pediatr Neurosurg. 2007;43:265–78.PubMedCrossRef
43.
go back to reference Suh JH, Gupta N. Role of radiation therapy and radiosurgery in the management of craniopharyngiomas. Neurosurg Clin N Am. 2006;17:143–8.PubMedCrossRef Suh JH, Gupta N. Role of radiation therapy and radiosurgery in the management of craniopharyngiomas. Neurosurg Clin N Am. 2006;17:143–8.PubMedCrossRef
44.
go back to reference Crawford JR, Santi MR, Vezina G, et al. CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis. Neurology. 2007;68:1668–73.PubMedCrossRef Crawford JR, Santi MR, Vezina G, et al. CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis. Neurology. 2007;68:1668–73.PubMedCrossRef
45.
go back to reference Al-Hussaini M, Sultan I, Abuirmileh N, et al. Pineal gland tumors: experience from the SEER database. J Neurooncol. 2009;94:351–8.PubMedCrossRef Al-Hussaini M, Sultan I, Abuirmileh N, et al. Pineal gland tumors: experience from the SEER database. J Neurooncol. 2009;94:351–8.PubMedCrossRef
46.
go back to reference Baumgartner JE, Sorenson JM. Meningioma in the pediatric population. J Neurooncol. 1996;29:223–8.PubMedCrossRef Baumgartner JE, Sorenson JM. Meningioma in the pediatric population. J Neurooncol. 1996;29:223–8.PubMedCrossRef
47.
48.
go back to reference Ng WH, Mukhida K, Rutka JT. Image guidance and neuromonitoring in neurosurgery. Childs Nerv Syst. 2010;26:491–502.PubMedCrossRef Ng WH, Mukhida K, Rutka JT. Image guidance and neuromonitoring in neurosurgery. Childs Nerv Syst. 2010;26:491–502.PubMedCrossRef
49.
go back to reference Kirsch DG, Tarbell NJ. Conformal radiation therapy for childhood CNS tumors. Oncologist. 2004;9:442–50.PubMedCrossRef Kirsch DG, Tarbell NJ. Conformal radiation therapy for childhood CNS tumors. Oncologist. 2004;9:442–50.PubMedCrossRef
50.
go back to reference Yock TI, Tarbell NJ. Technology insight: Proton beam radiotherapy for treatment in pediatric brain tumors. Nat Clin Pract Oncol. 2004;1:97–103.PubMedCrossRef Yock TI, Tarbell NJ. Technology insight: Proton beam radiotherapy for treatment in pediatric brain tumors. Nat Clin Pract Oncol. 2004;1:97–103.PubMedCrossRef
51.
go back to reference Gottardo NG, Gajjar A. Chemotherapy for malignant brain tumors of childhood. J Child Neurol. 2008;23:1149–59.PubMedCrossRef Gottardo NG, Gajjar A. Chemotherapy for malignant brain tumors of childhood. J Child Neurol. 2008;23:1149–59.PubMedCrossRef
52.
go back to reference Zacharoulis S, Levy A, Chi SN, et al. Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. Pediatr Blood Cancer. 2007;49:34–40.PubMedCrossRef Zacharoulis S, Levy A, Chi SN, et al. Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. Pediatr Blood Cancer. 2007;49:34–40.PubMedCrossRef
54.
go back to reference Armstrong GT, Liu Q, Yasui Y, et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009;101:946–58.PubMedCrossRef Armstrong GT, Liu Q, Yasui Y, et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009;101:946–58.PubMedCrossRef
55.
go back to reference Bhat SR, Goodwin TL, Burwinkle TM, et al. Profile of daily life in children with brain tumors: an assessment of health-related quality of life. J Clin Oncol. 2005;23:5493–500.PubMedCrossRef Bhat SR, Goodwin TL, Burwinkle TM, et al. Profile of daily life in children with brain tumors: an assessment of health-related quality of life. J Clin Oncol. 2005;23:5493–500.PubMedCrossRef
56.
go back to reference Reimers TS, Ehrenfels S, Mortensen EL, et al. Cognitive deficits in long-term survivors of childhood brain tumors: Identification of predictive factors. Med Pediatr Oncol. 2003;40:26–34.PubMedCrossRef Reimers TS, Ehrenfels S, Mortensen EL, et al. Cognitive deficits in long-term survivors of childhood brain tumors: Identification of predictive factors. Med Pediatr Oncol. 2003;40:26–34.PubMedCrossRef
57.
go back to reference Mulhern RK, Reddick WE, Palmer SL, et al. Neurocognitive deficits in medulloblastoma survivors and white matter loss. Ann Neurol. 1999;46:834–41.PubMedCrossRef Mulhern RK, Reddick WE, Palmer SL, et al. Neurocognitive deficits in medulloblastoma survivors and white matter loss. Ann Neurol. 1999;46:834–41.PubMedCrossRef
58.
go back to reference Packer RJ, Sutton LN, Atkins TE, et al. A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg. 1989;70:707–13.PubMedCrossRef Packer RJ, Sutton LN, Atkins TE, et al. A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg. 1989;70:707–13.PubMedCrossRef
59.
go back to reference Beebe DW, Ris MD, Armstrong FD, et al. Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130). J Clin Oncol. 2005;23:5198–204.PubMedCrossRef Beebe DW, Ris MD, Armstrong FD, et al. Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130). J Clin Oncol. 2005;23:5198–204.PubMedCrossRef
60.
go back to reference Turner CD, Rey-Casserly C, Liptak CC, Chordas C. Late effects of therapy for pediatric brain tumor survivors. J Child Neurol. 2009;24:1455–63.PubMedCrossRef Turner CD, Rey-Casserly C, Liptak CC, Chordas C. Late effects of therapy for pediatric brain tumor survivors. J Child Neurol. 2009;24:1455–63.PubMedCrossRef
61.
go back to reference Gurney JG, Kadan-Lottick NS, Packer RJ, et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer. 2003;97:663–73.PubMedCrossRef Gurney JG, Kadan-Lottick NS, Packer RJ, et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer. 2003;97:663–73.PubMedCrossRef
62.
go back to reference Pollack IF, Finkelstein SD,Woods J, et al. Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med. 2002;346:420–7.PubMedCrossRef Pollack IF, Finkelstein SD,Woods J, et al. Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med. 2002;346:420–7.PubMedCrossRef
63.
go back to reference Raffel C, Frederick L, O’Fallon JR, et al. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin Cancer Res. 1999;5:4085–90.PubMed Raffel C, Frederick L, O’Fallon JR, et al. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin Cancer Res. 1999;5:4085–90.PubMed
64.
go back to reference Ridley L, Rahman R, Brundler MA, et al. Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. Neuro Oncol. 2008;10:675–89.PubMedCrossRef Ridley L, Rahman R, Brundler MA, et al. Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. Neuro Oncol. 2008;10:675–89.PubMedCrossRef
65.
go back to reference Crawford JR, MacDonald TJ, Packer RJ. Medulloblastoma in childhood: new biological advances. Lancet Neurol. 2007;6:1073–85.PubMedCrossRef Crawford JR, MacDonald TJ, Packer RJ. Medulloblastoma in childhood: new biological advances. Lancet Neurol. 2007;6:1073–85.PubMedCrossRef
66.
go back to reference Faury D, Nantel A, Dunn SE, et al. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J Clin Oncol. 2007;25:1196–208.PubMedCrossRef Faury D, Nantel A, Dunn SE, et al. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J Clin Oncol. 2007;25:1196–208.PubMedCrossRef
67.
go back to reference Gilbertson RJ, Ellison DW. The origins of medulloblastoma subtypes. Annu Rev Pathol. 2008;3: 341–65.PubMedCrossRef Gilbertson RJ, Ellison DW. The origins of medulloblastoma subtypes. Annu Rev Pathol. 2008;3: 341–65.PubMedCrossRef
68.
go back to reference Kool M, Koster J, Bunt J, et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One. 2008;3:e3088.PubMedCrossRef Kool M, Koster J, Bunt J, et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One. 2008;3:e3088.PubMedCrossRef
69.
go back to reference Mir SE, De Witt Hamer PC, Krawczyk PM, et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell. 2010;18:244–57.PubMedCrossRef Mir SE, De Witt Hamer PC, Krawczyk PM, et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell. 2010;18:244–57.PubMedCrossRef
Metagegevens
Titel
Hersentumoren op kinderleeftijd
Auteurs
Dhr. drs. D. Molanus
Dhr.drs. D.G. van Vuurden
dhr. drs. S.E. Mir
dhr. prof.dr. G.J.L. Kaspers
Dhr. dr. R.J. Vermeulen
Mw. ir. C.M. Korbijn
Dhr. prof.dr. W.P. Vandertop
Publicatiedatum
01-10-2011
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Tijdschrift voor Kindergeneeskunde / Uitgave 5/2011
Print ISSN: 0376-7442
Elektronisch ISSN: 1875-6840
DOI
https://doi.org/10.1007/s12456-011-0029-4

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