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Gepubliceerd in: Kind en adolescent 4/2009

01-12-2009 | Artikelen

Genen in ontwikkeling

Auteur: Marian M. J. Bakermans-Kranenburg

Gepubliceerd in: Kind en adolescent | Uitgave 4/2009

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Samenvatting

De invloed van opvoeding op kinderen is in de afgelopen decennia soms flink ter discussie gesteld; de invloed van genen zou in verhouding veel groter zijn. Recente genetische studies wijzen op het samenspel van genen en omgeving (gen-omgevinginteractie ofwel g×e) en proberen gedeelde en ongedeelde omgevingsinvloeden te specificeren). In onze eigen studies naar gehechtheid en externaliserend probleemgedrag vonden we geen hoofdeffecten voor genetische factoren, maar wel consistente g×e-effecten. Aan de hand van die resultaten wordt het verschil besproken tussen risicogenen en verschil in ontvankelijkheid als context voor de interpretatie van g×e-effecten (bij zowel kinderen als ouders). Genen die invloed hebben op het dopaminesysteem spelen wellicht een rol bij het verklaren van verschillen in ontvankelijkheid voor invloeden uit de omgeving. Zorgvuldige meting van zowel genen als omgeving, en deskundige interventie als beïnvloeding van de (opvoedings)omgeving zijn essentieel voor goed onderzoek naar de rol van genen en omgeving in de ontwikkeling.
Literatuur
go back to reference Alink, L. R. A., Van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Mesman, J., Juffer, F., & Koot, H. M. (2008). Cortisol and externalizing behavior in children and adolescents: Mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Developmental Psychobiology, 50, 427-450. Alink, L. R. A., Van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Mesman, J., Juffer, F., & Koot, H. M. (2008). Cortisol and externalizing behavior in children and adolescents: Mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Developmental Psychobiology, 50, 427-450.
go back to reference Bakermans-Kranenburg, M. J. & Van IJzendoorn, M. H. (2006). Gene-environment interaction of the dopamine d4 receptor (drd4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Developmental Psychobiology, 48, 406-409. Bakermans-Kranenburg, M. J. & Van IJzendoorn, M. H. (2006). Gene-environment interaction of the dopamine d4 receptor (drd4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Developmental Psychobiology, 48, 406-409.
go back to reference Bakermans-Kranenburg, M. J. & Van IJzendoorn, M. H. (2007). Genetic vulnerability or differential susceptibility in child development: The case of attachment. Journal of Child Psychology and Psychiatry, 48, 1160-1173. Bakermans-Kranenburg, M. J. & Van IJzendoorn, M. H. (2007). Genetic vulnerability or differential susceptibility in child development: The case of attachment. Journal of Child Psychology and Psychiatry, 48, 1160-1173.
go back to reference Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2004). No association of the dopamine d4 receptor (drd4) and -521 c/t promoter polymorphisms with infant attachment disorganization. Attachment and Human Development, 6, 211-218. Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2004). No association of the dopamine d4 receptor (drd4) and -521 c/t promoter polymorphisms with infant attachment disorganization. Attachment and Human Development, 6, 211-218.
go back to reference Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Bokhorst, C. L., & Schuengel, C. (2004). The importance of shared environment in infant-father attachment: A behavioral genetic study of the Attachment Q-Sort. Journal of Family Psychology, 18, 545-549. Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Bokhorst, C. L., & Schuengel, C. (2004). The importance of shared environment in infant-father attachment: A behavioral genetic study of the Attachment Q-Sort. Journal of Family Psychology, 18, 545-549.
go back to reference Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Mesman, J., Alink, L. R. A., & Juffer, F. (2008). Effects of an attachment-based intervention on daily cortisol moderated by drd4: A randomized control trial on 1-3-year-olds screened for externalizing behavior. Development and Psychopathology, 20, 805-820. Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Mesman, J., Alink, L. R. A., & Juffer, F. (2008). Effects of an attachment-based intervention on daily cortisol moderated by drd4: A randomized control trial on 1-3-year-olds screened for externalizing behavior. Development and Psychopathology, 20, 805-820.
go back to reference Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Differential susceptibility to intervention: dopamine d4 receptor polymorphism (drd4 vntr) moderates effects on toddlers’ externalizing behavior in a randomized control trial. Developmental Psychology, 44, 293-300. Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Differential susceptibility to intervention: dopamine d4 receptor polymorphism (drd4 vntr) moderates effects on toddlers’ externalizing behavior in a randomized control trial. Developmental Psychology, 44, 293-300.
go back to reference Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304. Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304.
go back to reference Bokhorst, C. L., Bakermans-Kranenburg, M. J., Fearon, P., Van IJzendoorn, M. H., Fonagy, P., & Schuengel, C. (2003). The importance of shared environment in mother-infant attachment security: A behavioral genetic study. Child Development, 74, 1769-1782. Bokhorst, C. L., Bakermans-Kranenburg, M. J., Fearon, P., Van IJzendoorn, M. H., Fonagy, P., & Schuengel, C. (2003). The importance of shared environment in mother-infant attachment security: A behavioral genetic study. Child Development, 74, 1769-1782.
go back to reference Breimer, D. D. (2007). De maat der dingen. (Diesoratie.) Leiden: Universiteit Leiden. Breimer, D. D. (2007). De maat der dingen. (Diesoratie.) Leiden: Universiteit Leiden.
go back to reference Bruder, C. E. G., Piotrowski, A., Gijsbers, A. A. C. J., Andersson, R., Erickson, S., Diaz de Stahl, T., e.a. (2008). Phenotypically concordant and discordant monozygotic twins display different dna copy-number-variation profiles. American Journal of Human Genetics, 82, 763-771. Bruder, C. E. G., Piotrowski, A., Gijsbers, A. A. C. J., Andersson, R., Erickson, S., Diaz de Stahl, T., e.a. (2008). Phenotypically concordant and discordant monozygotic twins display different dna copy-number-variation profiles. American Journal of Human Genetics, 82, 763-771.
go back to reference Caspers, K., Yucuis, R., Troutman B., Arndt, S., & Langbehn, D. (2007). A sibling adoption study of adult attachment: The influence of shared environment on attachment states of mind. Attachment and Human Development, 9, 375-391. Caspers, K., Yucuis, R., Troutman B., Arndt, S., & Langbehn, D. (2007). A sibling adoption study of adult attachment: The influence of shared environment on attachment states of mind. Attachment and Human Development, 9, 375-391.
go back to reference Champagne, D. L., Bagot, R. C., Van Hasselt, F., Ramakers, G., Meaney, M. J., De Kloet, E.R., e.a. (2008). Maternal care and hippocampal plasticity: Evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. Journal of Neuroscience, 28, 6037- 6045. Champagne, D. L., Bagot, R. C., Van Hasselt, F., Ramakers, G., Meaney, M. J., De Kloet, E.R., e.a. (2008). Maternal care and hippocampal plasticity: Evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. Journal of Neuroscience, 28, 6037- 6045.
go back to reference Curtis, J. W., & Nelson, C. A. (2003). Toward building a better brain: Neurobehavioral outcomes, mechanisms, and processes of environmental enrichment. In S. Luthar (Ed.), Resilience and vulnerability: Adaptation in the context of childhood adversities (pp. 463-488). Londen: Cambridge University Press. Curtis, J. W., & Nelson, C. A. (2003). Toward building a better brain: Neurobehavioral outcomes, mechanisms, and processes of environmental enrichment. In S. Luthar (Ed.), Resilience and vulnerability: Adaptation in the context of childhood adversities (pp. 463-488). Londen: Cambridge University Press.
go back to reference Eaves, L., Heath, A., Martin, N., Maes, H., Neale, M., Kendler, K., Kirk, K., & Corey, L. (1999). Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Research, 2, 62-80. Eaves, L., Heath, A., Martin, N., Maes, H., Neale, M., Kendler, K., Kirk, K., & Corey, L. (1999). Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Research, 2, 62-80.
go back to reference Fearon, R. M. P., Van IJzendoorn, M. H., Fonagy, P., Bakermans-Kranenburg, M. J., Schuengel, C., & Bokhorst, C. L. (2006). In search of shared and non-shared environmental factors in security of attachment: A behavior-genetic study of the association between sensitivity and attachment security. Developmental Psychology, 42, 1026-1040. Fearon, R. M. P., Van IJzendoorn, M. H., Fonagy, P., Bakermans-Kranenburg, M. J., Schuengel, C., & Bokhorst, C. L. (2006). In search of shared and non-shared environmental factors in security of attachment: A behavior-genetic study of the association between sensitivity and attachment security. Developmental Psychology, 42, 1026-1040.
go back to reference Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., e.a. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences, 102, 10604-10609. Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., e.a. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences, 102, 10604-10609.
go back to reference Gunning, J. H., Banning, W., Ten Bokkel Huinink, A., Hoogveld, J., Kohnstamm, Ph., Van Rooy, A. H. M. J., e.a. (1938). Ons kind. Gids voor jonge ouders. Amsterdam: Wereldbibliotheek. Gunning, J. H., Banning, W., Ten Bokkel Huinink, A., Hoogveld, J., Kohnstamm, Ph., Van Rooy, A. H. M. J., e.a. (1938). Ons kind. Gids voor jonge ouders. Amsterdam: Wereldbibliotheek.
go back to reference Harris, J. R. (1999). Het misverstand opvoeding. Over de invloed van ouders op kinderen. Amsterdam: Contact. Harris, J. R. (1999). Het misverstand opvoeding. Over de invloed van ouders op kinderen. Amsterdam: Contact.
go back to reference Henig, R. M. (2000). The monk in the garden. The lost and found genius of Gregor Mendel, the father of genetics. New York: Mariner Books. Henig, R. M. (2000). The monk in the garden. The lost and found genius of Gregor Mendel, the father of genetics. New York: Mariner Books.
go back to reference Heselmans, M. (2007). Revolutie in dna sequencing brengt duizend-dollargenoom nabij. NRC Handelsblad, 13 oktober 2007. Heselmans, M. (2007). Revolutie in dna sequencing brengt duizend-dollargenoom nabij. NRC Handelsblad, 13 oktober 2007.
go back to reference Juffer, F., Bakermans-Kranenburg, M. J. & Van IJzendoorn, M. H. (2008). Promoting positive parenting: An attachment-based intervention. Mahwah, nj: Lawrence Erlbaum. Juffer, F., Bakermans-Kranenburg, M. J. & Van IJzendoorn, M. H. (2008). Promoting positive parenting: An attachment-based intervention. Mahwah, nj: Lawrence Erlbaum.
go back to reference Klein, T. A., Neumann, J., Reuter, M., Hennig, J., Von Cramon, D. Y., & Ullsperger, M. (2007). Genetically determined learning from errors. Science, 318, 1642-1645. Klein, T. A., Neumann, J., Reuter, M., Hennig, J., Von Cramon, D. Y., & Ullsperger, M. (2007). Genetically determined learning from errors. Science, 318, 1642-1645.
go back to reference Lakatos, K., Nemoda, Z., Toth, I., Ronai, Z., Ney, K., Sasvari-Szekely, M., e.a. (2002). Further evidence for the role of the dopamine d4 receptor (drd4) gene in attachment disorganization: Interaction of the exon iii 48-bp repeat and the 521 c/t promoter polymorphisms. Molecular Psychiatry, 7, 27-31. Lakatos, K., Nemoda, Z., Toth, I., Ronai, Z., Ney, K., Sasvari-Szekely, M., e.a. (2002). Further evidence for the role of the dopamine d4 receptor (drd4) gene in attachment disorganization: Interaction of the exon iii 48-bp repeat and the 521 c/t promoter polymorphisms. Molecular Psychiatry, 7, 27-31.
go back to reference Lakatos, K., Toth, I., Nemoda, Z., Ney, K., Sasvari-Szekely, M., & Gervai, J. (2000). Dopamine d4 receptor (drd4) gene polymorphism is associated with attachment disorganization in infants. Molecular Psychiatry, 5, 633-637. Lakatos, K., Toth, I., Nemoda, Z., Ney, K., Sasvari-Szekely, M., & Gervai, J. (2000). Dopamine d4 receptor (drd4) gene polymorphism is associated with attachment disorganization in infants. Molecular Psychiatry, 5, 633-637.
go back to reference McGuffin, P., Riley, B., & Plomin, R. (2001). Toward behavioral genomics. Science, 291, 1232-1249. McGuffin, P., Riley, B., & Plomin, R. (2001). Toward behavioral genomics. Science, 291, 1232-1249.
go back to reference Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161-1192. Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161-1192.
go back to reference Meaney, M. J., & Szyf, M. (2005). Maternal care as a model for experience-dependent chromatin plasticity? Trends in Neurosciences, 28, 456-463. Meaney, M. J., & Szyf, M. (2005). Maternal care as a model for experience-dependent chromatin plasticity? Trends in Neurosciences, 28, 456-463.
go back to reference Munafo, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008). Association of the dopamine D4 receptor (drd4) gene and approach-related personality traits: Meta-analysis and new data. Biological Psychiatry, 63, 197-206. Munafo, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008). Association of the dopamine D4 receptor (drd4) gene and approach-related personality traits: Meta-analysis and new data. Biological Psychiatry, 63, 197-206.
go back to reference Oates, N. A., Van Vliet, J., Duffy, D. L., Kroes, H. Y., Martin, N. G., Boomsma, D. I., Campbell, M., Coulthard, M. G., Whitelaw, E., & Chong S. (2008). Increased dna methylation at the axin1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. American Journal of Human Genetics, 79, 155-162. Oates, N. A., Van Vliet, J., Duffy, D. L., Kroes, H. Y., Martin, N. G., Boomsma, D. I., Campbell, M., Coulthard, M. G., Whitelaw, E., & Chong S. (2008). Increased dna methylation at the axin1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. American Journal of Human Genetics, 79, 155-162.
go back to reference Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioral genetics (4th ed.). New York: Worth. Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioral genetics (4th ed.). New York: Worth.
go back to reference Rowe, D. C. (1994). The limits of family influence: Genes, experience, and behavior. New York, Guilford. Rowe, D. C. (1994). The limits of family influence: Genes, experience, and behavior. New York, Guilford.
go back to reference Tripp, G., & Wickens, J. R. (2008). Dopamine transfer deficit: A neurobiological theory of altered reinforcement mechanisms in adhd. Journal of Child Psychology and Psychiatry, 49, 691-704. Tripp, G., & Wickens, J. R. (2008). Dopamine transfer deficit: A neurobiological theory of altered reinforcement mechanisms in adhd. Journal of Child Psychology and Psychiatry, 49, 691-704.
go back to reference Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 13, 131-146. Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 13, 131-146.
go back to reference Van IJzendoorn, M. H. (1983). Van wijsgerige naar theoretische pedagogiek. Over de taken van de theoretische pedagogiek bij onderzoek naar vroegkinderlijke ontwikkeling. Deventer: Van Loghum Slaterus. Van IJzendoorn, M. H. (1983). Van wijsgerige naar theoretische pedagogiek. Over de taken van de theoretische pedagogiek bij onderzoek naar vroegkinderlijke ontwikkeling. Deventer: Van Loghum Slaterus.
go back to reference Van IJzendoorn, M. H. (1984). Answers without questions: a note on response style in questionnaires. Perceptual and Motor Skills, 59, 827-831. Van IJzendoorn, M. H. (1984). Answers without questions: a note on response style in questionnaires. Perceptual and Motor Skills, 59, 827-831.
go back to reference Van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2006). drd4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization. Attachment and Human Development, 8, 291-307. Van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2006). drd4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization. Attachment and Human Development, 8, 291-307.
go back to reference Van IJzendoorn, M. H., Schuengel, C., & Bakermans-Kranenburg, M. J. (1999). Disorganized attachment in early childhood: Meta-analysis of precursors, concomitants, and sequelae. Development and Psychopathology, 11, 225-249. Van IJzendoorn, M. H., Schuengel, C., & Bakermans-Kranenburg, M. J. (1999). Disorganized attachment in early childhood: Meta-analysis of precursors, concomitants, and sequelae. Development and Psychopathology, 11, 225-249.
go back to reference Van Zeijl, J., Mesman, J., Van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Juffer, F., Stolk, e.a. (2006). Attachment-based intervention for enhancing sensitive discipline in mothers of 1- to 3-year-old children at risk for externalizing behavior problems: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 74, 994-1005. Van Zeijl, J., Mesman, J., Van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Juffer, F., Stolk, e.a. (2006). Attachment-based intervention for enhancing sensitive discipline in mothers of 1- to 3-year-old children at risk for externalizing behavior problems: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 74, 994-1005.
go back to reference Waterink, J. (1958). Theorie der opvoeding. Kampen: Kok. Waterink, J. (1958). Theorie der opvoeding. Kampen: Kok.
Metagegevens
Titel
Genen in ontwikkeling
Auteur
Marian M. J. Bakermans-Kranenburg
Publicatiedatum
01-12-2009
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Kind en adolescent / Uitgave 4/2009
Print ISSN: 0167-2436
Elektronisch ISSN: 1876-5998
DOI
https://doi.org/10.1007/BF03087958

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