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14-02-2019 | Original Article – Design Study Article | Uitgave 4/2019 Open Access

Netherlands Heart Journal 4/2019

Extra energy for hearts with a genetic defect: ENERGY trial

Tijdschrift:
Netherlands Heart Journal > Uitgave 4/2019
Auteurs:
B. O. van Driel, A. C. van Rossum, M. Michels, R. Huurman, J. van der Velden
Belangrijke opmerkingen
A correction to this article is available online at https://​doi.​org/​10.​1007/​s12471-019-1263-0.

Abstract

Aims

Previous studies have shown that hypertrophic cardiomyopathy mutation carriers have a decreased myocardial energy efficiency, which is thought to play a key role in the pathomechanism of hypertrophic cardiomyopathy (HCM). The ENERGY trial aims to determine whether metabolic drugs correct decreased myocardial energy efficiency in HCM mutation carriers at an early disease stage.

Methods

40 genotype-positive, phenotype-negative MYH7 mutation carriers will be treated for two months with trimetazidine or placebo in a double-blind randomised study design. Directly before and after treatment, study subjects will undergo an [11C]-acetate positron emission tomography/computed tomography (PET/CT) and cardiac magnetic resonance (CMR) scan to measure myocardial energy efficiency. Myocardial efficiency will be calculated as the amount of oxygen the heart consumes to perform work.

Conclusion

The ENERGY trial will be the first proof of concept study to determine whether metabolic drugs are a potential preventive therapy for HCM. Given that trimetazidine is already being used in clinical practice, there is large potential to swiftly implement this drug in HCM therapy.

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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