Fig. 1
The ratio between external work and myocardial oxygen consumption to obtain myocardial external efficiency was determined in 28 asymptomatic mutation carriers (14 MYBPC3 and 14 MYH7), 10 manifest HCM patients and 14 healthy controls using [11C]-acetate positron emission tomography (PET) and cardiovascular magnetic resonance imaging (CMR). a CMR-derived cardiac 4‑chamber view and parametric images of [11C]-acetate PET derived k2 with corresponding polar maps. As can be seen clearly, oxygen metabolism was higher in asymptomatic mutation carriers compared to controls [7]. b Myocardial efficiency is not further reduced in advanced HCM patients compared with mutation carriers [8]