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Journal of Autism and Developmental Disorders

Gepubliceerd in:

09-06-2022 | Original Paper

Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression

Auteurs: Meghan E. Carey, Juliette Rando, Stepan Melnyk, S Jill James, Nathaniel Snyder, Carolyn Salafia, Lisa A. Croen, M Daniele Fallin, Irva Hertz-Picciotto, Heather Volk, Craig Newschaffer, Kristen Lyall

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2023

Abstract

We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling’s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

vorige artikel A Preliminary Evaluation of a Brief Behavioral Parent Training for Challenging Behavior in Autism Spectrum Disorder

volgende artikel “Um” and “Uh” Usage Patterns in Children with Autism: Associations with Measures of Structural and Pragmatic Language Ability

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Atamer, Y., Koçyigit, Y., Yokus, B., Atamer, A., & Erden, A. C. (2005). Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 119(1), 60–66CrossRef

Berr, C., Balansard, B., Arnaud, J., Roussel, A. M., Alpérovitch, A., & Group, E. S. (2000). Cognitive decline is associated with systemic oxidative stress: the EVA study. Journal of the American Geriatrics Society, 48(10), 1285–1291CrossRefPubMed

Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S., & Kalayci, O. (2012). Oxidative stress and antioxidant defense. World Allergy Organization Journal, 5(1), 9–19CrossRefPubMedPubMedCentral

Bishop, S. L., Guthrie, W., Coffing, M., & Lord, C. (2011). Convergent validity of the Mullen Scales of Early Learning and the differential ability scales in children with autism spectrum disorders. American journal on intellectual and developmental disabilities, 116(5), 331–343CrossRefPubMedPubMedCentral

Boyle, C. A., Boulet, S., Schieve, L. A., Cohen, R. A., Blumberg, S. J., Yeargin-Allsopp, M., & Kogan, M. D. (2011). Trends in the prevalence of developmental disabilities in US children, 1997–2008. Pediatrics, 127(6), 1034–1042CrossRefPubMed

Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., & Reich, W. (2003). Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of autism and developmental disorders, 33(4), 427–433CrossRefPubMed

Constantino, J. N., & Gruber, C. P. (2012). The social responsiveness scale (2nd ed.).). Western Psychological Services

Dennery, P. A. (2010). Oxidative stress in development: nature or nurture? Free Radical Biology and Medicine, 49(7), 1147–1151CrossRefPubMed

DeVilbiss, E. A., Gardner, R. M., Newschaffer, C. J., & Lee, B. K. (2015). Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence. British Journal of Nutrition, 114(5), 663–672CrossRefPubMed

Goodrich, A. J., Volk, H. E., Tancredi, D. J., McConnell, R., Lurmann, F. W., Hansen, R. L., & Schmidt, R. J. (2018). Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder. Autism Research, 11(1), 69–80CrossRefPubMed

Hajjar, I., Hayek, S. S., Goldstein, F. C., Martin, G., Jones, D. P., & Quyyumi, A. (2018). Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study. Journal of Neuroinflammation, 15(1), 1–7CrossRef

Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., & Smith, K. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of general psychiatry, 68(11), 1095–1102CrossRefPubMedPubMedCentral

Hollowood, K., Melnyk, S., Pavliv, O., Evans, T., Sides, A., Schmidt, R. J., & Kruger, U. (2018). Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome. Research in autism spectrum disorders, 56, 72–82CrossRefPubMedPubMedCentral

Howsmon, D. P., Kruger, U., Melnyk, S., James, S. J., & Hahn, J. (2017). Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation.PLoS computational biology, 13(3), e1005385

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition, 80(6), 1611–1617CrossRefPubMed

James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., & Bradstreet, J. J. (2006). Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141(8), 947–956CrossRef

Jenabi, E., Karami, M., Khazaei, S., & Bashirian, S. (2019). The association between preeclampsia and autism spectrum disorders among children: a meta-analysis. Korean journal of pediatrics, 62(4), 126–130. doi:https://doi.org/10.3345/kjp.2018.07010CrossRefPubMed

Jones, D. P. (2002). [11] Redox potential of GSH/GSSG couple: assay and biological significance. Methods in enzymology, 348, 93–112CrossRefPubMed

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015). The role of oxidative stress in neurodegenerative diseases. Experimental neurobiology, 24(4), 325CrossRefPubMedPubMedCentral

quantreg: Quantile Regression. R package version 5.85. (2021). Koenker, R. [Mobile application software]

Koenker, R., & Hallock, K. F. (2001). Quantile regression. Journal of economic perspectives, 15(4), 143–156CrossRef

Lanté, F., Meunier, J., Guiramand, J., Maurice, T., Cavalier, M., de Jesus Ferreira, M. C., & Barbanel, G. (2007). Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain. Free Radical Biology and Medicine, 42(8), 1231–1245. doi:https://doi.org/10.1016/j.freeradbiomed.2007.01.027CrossRefPubMed

Lawson, J. A., FitzGerald, G. A., & Rokach, J. (1999). Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. Journal of Biological Chemistry, 274(35), 24441–24444CrossRefPubMed

London, E. B. (2014). Categorical diagnosis: a fatal flaw for autism research? Trends in neurosciences, 37(12), 683–686CrossRefPubMed

López-Tinoco, C., Roca, M., García-Valero, A., Murri, M., Tinahones, F. J., Segundo, C., & Aguilar-Diosdado, M. (2013). Oxidative stress and antioxidant status in patients with late-onset gestational diabetes mellitus. Acta Diabetologica, 50(2), 201–208. doi:https://doi.org/10.1007/s00592-011-0264-2CrossRefPubMed

Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Austism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of autism and developmental disorders, 19(2), 185–212CrossRefPubMed

Lyall, K., Croen, L., Daniels, J., Fallin, M. D., Ladd-Acosta, C., Lee, B. K., & Volk, H. (2017). The changing epidemiology of autism spectrum disorders. Annual review of public health, 38, 81–102CrossRefPubMed

Lyall, K., Pauls, D. L., Spiegelman, D., Ascherio, A., & Santangelo, S. L. (2012). Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses’ Health Study II. Autism Research, 5(1), 21–30CrossRefPubMed

Maenner, M. J., Shaw, K. A., Baio, J., EdS, Washington, A., Patrick, M., Dietz, P. M., & United States. (2020). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, 2016. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C.: 2002), 69(4), 1–12. doi:https://doi.org/10.15585/mmwr.ss6904a1

Matsubasa, T., Uchino, T., Karashima, S., Kondo, Y., Maruyama, K., Tanimura, M., & Endo, F. (2002). Oxidative stress in very low birth weight infants as measured by urinary 8-OHdG. Free Radical Biology and Medicine, 36(2), 189–193CrossRef

Melnyk, S., Fuchs, G. J., Schulz, E., Lopez, M., Kahler, S. G., Fussell, J. J., & Seidel, L. (2012). Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. Journal of autism and developmental disorders, 42(3), 367–377CrossRefPubMedPubMedCentral

Moore, T. A., Ahmad, I. M., Schmid, K. K., Berger, A. M., Ruiz, R. J., Pickler, R. H., & Zimmerman, M. C. (2019). Oxidative stress levels throughout pregnancy, at birth, and in the neonate. Biological research for nursing, 21(5), 485–494CrossRefPubMedPubMedCentral

Mullen, E. M. (1995). Mullen scales of early learning manual. American Guidance Service

Neggers, Y. (2014). The Relationship between Folic Acid and Risk of Autism Spectrum Disorders. Healthcare (Basel Switzerland), 2(4), 429–444. doi:https://doi.org/10.3390/healthcare2040429CrossRefPubMed

Newschaffer, C. J., Croen, L. A., Fallin, M. D., Hertz-Picciotto, I., Nguyen, D. V., Lee, N. L., & Shedd-Wise, K. M. (2012). Infant siblings and the investigation of autism risk factors. Journal of Neurodevelopmental Disorders, 4(1), 7. doi:https://doi.org/10.1186/1866-1955-4-7CrossRefPubMedPubMedCentral

Ozonoff, S., Young, G. S., Belding, A., Hill, M., Hill, A., Hutman, T., & Schwichtenberg, A. (2014). The broader autism phenotype in infancy: when does it emerge? Journal of the American Academy of Child & Adolescent Psychiatry, 53(4), 398–407. e392CrossRef

Olsson, M. G., Centlow, M., Rutardóttir, S., Stenfors, I., Larsson, J., Hosseini-Maaf, B. … Akerström, B. (2010). Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia. Free Radical Biology and Medicine, 48(2), 284–291CrossRefPubMed

Patti, M. A., Newschaffer, C., Eliot, M., Hamra, G. B., Chen, A., Croen, L. A., & Khoury, J. C. (2021). Gestational exposure to phthalates and social responsiveness scores in children using quantile regression: The EARLI and HOME studies. International journal of environmental research and public health, 18(3), 1254CrossRefPubMedPubMedCentral

Postorino, V., Fatta, L., Sanges, V., Giovagnoli, G., De Peppo, L., Vicari, S., & Mazzone, L. (2016). Intellectual disability in autism spectrum disorder: investigation of prevalence in an Italian sample of children and adolescents

Rice, D., & Barone, S. Jr. (2000). Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental health perspectives, 108(suppl 3), 511–533CrossRefPubMedPubMedCentral

Risch, N., Hoffmann, T. J., Anderson, M., Croen, L. A., Grether, J. K., & Windham, G. C. (2014). Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions. American Journal of Psychiatry, 171(11), 1206–1213CrossRefPubMed

Rommel, A. S., Milne, G. L., Barrett, E. S., Bush, N. R., Nguyen, R., Sathyanarayana, S., & Ferguson, K. K. (2020). Associations between urinary biomarkers of oxidative stress in the third trimester of pregnancy and behavioral outcomes in the child at 4 years of age. Brain Behavior and Immunity, 90, 272–278CrossRefPubMed

Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, T., Frye, R., & James, S. (2012). Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Translational psychiatry, 2(7), e134–e134CrossRefPubMedPubMedCentral

Sagiv, S. K., Kalkbrenner, A. E., & Bellinger, D. C. (2015). Of decrements and disorders: assessing impairments in neurodevelopment in prospective studies of environmental toxicant exposures. Environmental Health, 14(1), 1–4CrossRef

Sbodio, J. I., Snyder, S. H., & Paul, B. D. (2019). Regulators of the transsulfuration pathway. British journal of pharmacology, 176(4), 583–593. doi:https://doi.org/10.1111/bph.14446CrossRefPubMed

Schmidt, R. J., Hansen, R. L., Hartiala, J., Allayee, H., Schmidt, L. C., Tancredi, D. J., & Hertz-Picciotto, I. (2011). Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology (Cambridge Mass), 22(4), 476–485. doi:https://doi.org/10.1097/EDE.0b013e31821d0e30CrossRefPubMed

Shelton, J. F., Hertz-Picciotto, I., & Pessah, I. N. (2012). Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environmental health perspectives, 120(7), 944–951CrossRefPubMedPubMedCentral

Svatikova, A., Wolk, R., Wang, H. H., Otto, M. E., Bybee, K. A., Singh, R. J., & Somers, V. K. (2004). Circulating free nitrotyrosine in obstructive sleep apnea. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 287(2), R284–R287CrossRefPubMed

Thompson, L. P., & Al-Hasan, Y. (2012). Impact of oxidative stress in fetal programming. Journal of pregnancy, 2012

Toboła-Wróbel, K., Pietryga, M., Dydowicz, P., Napierała, M., Brązert, J., & Florek, E. (2020). Association of Oxidative Stress on Pregnancy. Oxidative Medicine and Cellular Longevity, 2020, 6398520. doi:https://doi.org/10.1155/2020/6398520

Valavanidis, A., Vlachogianni, T., & Fiotakis, C. (2009). 8-hydroxy-2′-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health Part C, 27(2), 120–139CrossRef

Van Naarden Braun, K., Christensen, D., Doernberg, N., Schieve, L., Rice, C., Wiggins, L., & Yeargin-Allsopp, M. (2015). Trends in the prevalence of autism spectrum disorder, cerebral palsy, hearing loss, intellectual disability, and vision impairment, metropolitan Atlanta, 1991–2010. PloS one, 10(4), e0124120CrossRefPubMedPubMedCentral

Wells, P. G., Bhatia, S., Drake, D. M., & Miller-Pinsler, L. (2016). Fetal oxidative stress mechanisms of neurodevelopmental deficits and exacerbation by ethanol and methamphetamine. Birth Defects Research Part C: Embryo Today: Reviews, 108(2), 108–130CrossRefPubMed

Wells, P. G., McCallum, G. P., Chen, C. S., Henderson, J. T., Lee, C. J., Perstin, J., & Wong, A. W. (2009). Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. Toxicological sciences, 108(1), 4–18CrossRefPubMed

Titel: Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression
Auteurs: Meghan E. Carey
Juliette Rando
Stepan Melnyk
S Jill James
Nathaniel Snyder
Carolyn Salafia
Lisa A. Croen
M Daniele Fallin
Irva Hertz-Picciotto
Heather Volk
Craig Newschaffer
Kristen Lyall
Publicatiedatum: 09-06-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05625-9

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