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Journal of Autism and Developmental Disorders

Gepubliceerd in:

09-06-2022 | Original Paper

Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression

Auteurs: Meghan E. Carey, Juliette Rando, Stepan Melnyk, S Jill James, Nathaniel Snyder, Carolyn Salafia, Lisa A. Croen, M Daniele Fallin, Irva Hertz-Picciotto, Heather Volk, Craig Newschaffer, Kristen Lyall

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2023

Abstract

We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling’s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

vorige artikel A Preliminary Evaluation of a Brief Behavioral Parent Training for Challenging Behavior in Autism Spectrum Disorder

volgende artikel “Um” and “Uh” Usage Patterns in Children with Autism: Associations with Measures of Structural and Pragmatic Language Ability

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Titel: Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression
Auteurs: Meghan E. Carey
Juliette Rando
Stepan Melnyk
S Jill James
Nathaniel Snyder
Carolyn Salafia
Lisa A. Croen
M Daniele Fallin
Irva Hertz-Picciotto
Heather Volk
Craig Newschaffer
Kristen Lyall
Publicatiedatum: 09-06-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05625-9

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