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26-05-2020 | Uitgave 9/2020 Open Access

Quality of Life Research 9/2020

EORTC QLU-C10D value sets for Austria, Italy, and Poland

Tijdschrift:
Quality of Life Research > Uitgave 9/2020
Auteurs:
E. M. Gamper, M. T. King, R. Norman, F. Efficace, F. Cottone, B. Holzner, G. Kemmler, the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-020-02536-z) contains supplementary material, which is available to authorized users.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Objective

To develop Austrian, Italian, and Polish general population value sets for the EORTC QLU-C10D, a cancer-specific utility instrument based on the EORTC QLQ-C30, and to descriptively compare their index scores for distinct health states.

Methods

The QLU-C10D descriptive system comprises 10 health attributes and each can take on 4 levels. A standardised and pre-tested methodology has been applied for valuations including a web-based discrete choice experiment (DCE). It was administered in 1000 general population respondents per country recruited via online panels, aiming at representativeness for core socio-demographic variables.

Results

In all three countries, the attributes with the largest impact on utility were physical functioning, pain, and role functioning. Cancer-specific dimensions with the largest impact were nausea and fatigue or bowel problems. Utility values of the worst health state (i.e. severe problems on all 10 dimension) were -0.111 (Austria), 0.025 (Italy), and 0.048 (Poland). Country-specific utilities differed for a selection of health states across the continuum. Austrian utilities were systematically lower for moderately and severely impaired health states.

Conclusion

QLU-C10D cancer-specific utilities can now be calculated in three more countries. Differences between countries indicate that careful consideration is required when using non-country-specific value sets in economic evaluations.

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