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One Method, Many Methodological Choices: A Structured Review of Discrete-Choice Experiments for Health State Valuation

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Abstract

Background

Discrete-choice experiments (DCEs) are used in the development of preference-based measure (PBM) value sets. There is considerable variation in the methodological approaches used to elicit preferences.

Objective

Our objective was to carry out a structured review of DCE methods used for health state valuation.

Methods

PubMed was searched until 31 May 2018 for published literature using DCEs for health state valuation. Search terms to describe DCEs, the process of valuation and preference-based instruments were developed. English language papers with any study population were included if they used DCEs to develop or directly inform the production of value sets for generic or condition-specific PBMs. Assessment of paper quality was guided by the recently developed Checklist for Reporting Valuation Studies. Data were extracted under six categories: general study information, choice task and study design, type of designed experiment, modelling and analysis methods, results and discussion.

Results

The literature search identified 1132 published papers, and 63 papers were included in the review. Paper quality was generally high. The study design and choice task formats varied considerably, and a wide range of modelling methods were employed to estimate value sets.

Conclusions

This review of DCE methods used for developing value sets suggests some recurring limitations, areas of consensus and areas where further research is required. Methodological diversity means that the values should be seen as experimental, and users should understand the features of the value sets produced before applying them in decision making.

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Acknowledgements

The authors thank Liz Chinchen for her support with the literature searching, and Elly Stolk for comments on an earlier version of the review. This work was presented at the EuroQol Group Plenary (Krakow 2015) and the International Society of Pharmacoeconomics and Outcomes Research (Washington 2016) meetings.

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Authors and Affiliations

  1. Centre for Health Economics Research and Evaluation, University of Technology, 1-59 Quay St, Haymarket, Sydney, NSW, 2000, Australia

    Brendan Mulhern, Deborah J. Street & Rosalie Viney

  2. School of Public Health, Curtin University, Kent Street, Bentley, Perth, WA, 6102, Australia

    Richard Norman

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Contributions

BM carried out the literature search, extracted the data, led the data synthesis and interpretation and developed the first draft of the manuscript. RN, RV and DJS supported the data-extraction process and interpretation of the results and were involved in the development of the manuscript.

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Correspondence to Brendan Mulhern.

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Funding

This review was partly funded by the Australian National Health and Medical Research Council. Mr Mulhern was funded by a University of Technology Sydney President’s Scholarship.

Conflicts of interest

BM, RN, DJS and RV have no conflicts of interest.

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No datasets were generated or analysed during this study.

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Mulhern, B., Norman, R., Street, D.J. et al. One Method, Many Methodological Choices: A Structured Review of Discrete-Choice Experiments for Health State Valuation. PharmacoEconomics 37, 29–43 (2019). https://doi.org/10.1007/s40273-018-0714-6

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