Skip to main content
Top
Gepubliceerd in: Neuropraxis 1/2012

01-02-2012

DeRotterdam Scan Study: een grootschalig MRI-onderzoek naar hersenziekten

Auteurs: Drs. Mariëlle Poels, Drs. Benjamin Verhaaren, Drs. Yoo Young Hoogendam, Dr. Arfan Ikram, Drs. Daniel Bos, Dr. Meike Vernooij

Gepubliceerd in: Neuropraxis | Uitgave 1/2012

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Dementia and stroke are common disorders in the elderly that have great impact on brain functioning and the way people live their lives. Magnetic Resonance Imaging (MRI) of the brain has proven to be an important tool for etiologic research on these neurological diseases. The Rotterdam Scan Study is a large-scale prospective population-based brain imaging study that aims to investigate causes and consequences of age-related brain changes. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study. In 1995 and 1999 random subsets of the Rotterdam Study underwent MRI of the brain, whereas from 2005 onwards MRI has been implemented into the core protocol of the Rotterdam Study. In this paper, we discuss the background of this study and summarize the main findings to date. Finally, plans for future research within the Rotterdam Scan Study are described.
Literatuur
1.
go back to reference Boer, R. de, Schaap, M., Lijn, F. van der, Vrooman, H.A., Groot, M. de, Lugt, A. van der (2011). Statistical analysis of minimum cost path based structural brain connectivity.Neuroimage, 55,2, 557-565. doi: S1053-8119(10)01594-6 [pii] 10.1016/j.neuroimage.2010.12.012 Boer, R. de, Schaap, M., Lijn, F. van der, Vrooman, H.A., Groot, M. de, Lugt, A. van der (2011). Statistical analysis of minimum cost path based structural brain connectivity.Neuroimage, 55,2, 557-565. doi: S1053-8119(10)01594-6 [pii] 10.1016/j.neuroimage.2010.12.012
2.
go back to reference Boer, R. de, Vrooman, H.A., Ikram, M.A., Vernooij, M.W., Breteler, M.M., Lugt, A. van der (2010). Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods.Neuroimage, 51,3, 1047-1056. doi: S1053-8119(10)00282-X [pii] 10.1016/j.neuroimage.2010.03.012 Boer, R. de, Vrooman, H.A., Ikram, M.A., Vernooij, M.W., Breteler, M.M., Lugt, A. van der (2010). Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods.Neuroimage, 51,3, 1047-1056. doi: S1053-8119(10)00282-X [pii] 10.1016/j.neuroimage.2010.03.012
3.
go back to reference Boer, R. de, Vrooman, H.A., Lijn, F. van der, Vernooij, M.W., Ikram, M.A., Lugt, A. van der (2009). White matter lesion extension to automatic brain tissue segmentation on MRI.Neuroimage, 45,4, 1151-1161. doi: S1053-8119(09)00056-1 [pii] 10.1016/j.neuromage.2009.01.011 Boer, R. de, Vrooman, H.A., Lijn, F. van der, Vernooij, M.W., Ikram, M.A., Lugt, A. van der (2009). White matter lesion extension to automatic brain tissue segmentation on MRI.Neuroimage, 45,4, 1151-1161. doi: S1053-8119(09)00056-1 [pii] 10.1016/j.neuromage.2009.01.011
4.
go back to reference Bos, D., Ikram, M.A., Elias-Smale, S.E., Krestin, G.P., Hofman, A. & Witteman, J.C. (2011). Calcification in major vessel beds relates to vascular brain disease.Arteriosclerosis, Thrombosis, and Vascular Biology, 31,10, 2331-2337. doi: ATVBAHA.111.232728 [pii] 10.1161/ATVBAHA.111.232728 Bos, D., Ikram, M.A., Elias-Smale, S.E., Krestin, G.P., Hofman, A. & Witteman, J.C. (2011). Calcification in major vessel beds relates to vascular brain disease.Arteriosclerosis, Thrombosis, and Vascular Biology, 31,10, 2331-2337. doi: ATVBAHA.111.232728 [pii] 10.1161/ATVBAHA.111.232728
5.
go back to reference Cocosco, C.A., Zijdenbos, A.P. & Evans, A.C. (2003). A fully automatic and robust brain MRI tissue classification method.Medical Image Analysis, 7,4, 513-527. doi: S1361841503000379 [pii] Cocosco, C.A., Zijdenbos, A.P. & Evans, A.C. (2003). A fully automatic and robust brain MRI tissue classification method.Medical Image Analysis, 7,4, 513-527. doi: S1361841503000379 [pii]
6.
go back to reference Debette, S., Bis, J.C., Fornage, M., Schmidt, H., Ikram, M.A., Sigurdsson, S. (2010). Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.Stroke, 41(2), 210-217. doi: STROKEAHA.109.569194 [pii] 10.1161-STROKEAHA.109.569194 Debette, S., Bis, J.C., Fornage, M., Schmidt, H., Ikram, M.A., Sigurdsson, S. (2010). Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.Stroke, 41(2), 210-217. doi: STROKEAHA.109.569194 [pii] 10.1161-STROKEAHA.109.569194
7.
go back to reference Dijk, E.J. van, Breteler, M.M., Schmidt, R., Berger, K., Nilsson, L.G. & Oudkerk, M. (2004). The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study.Hypertension, 44,5, 625-630. doi: 01.HYP.0000145857.98904.20 [pii] 10.1161-01.HYP.0000145857.98904.20 Dijk, E.J. van, Breteler, M.M., Schmidt, R., Berger, K., Nilsson, L.G. & Oudkerk, M. (2004). The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study.Hypertension, 44,5, 625-630. doi: 01.HYP.0000145857.98904.20 [pii] 10.1161-01.HYP.0000145857.98904.20
8.
go back to reference Dijk, E.J.van, Prins, N.D., Vermeer, S.E., Vrooman, H.A., Hofman, A. & Koudstaal, P.J. (2005). C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study.Circulation, 112,6, 900-905. doi: CIRCULATIONAHA.104.506337 [pii] 10.1161/CIRCULATIONAHA.104.506337 Dijk, E.J.van, Prins, N.D., Vermeer, S.E., Vrooman, H.A., Hofman, A. & Koudstaal, P.J. (2005). C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study.Circulation, 112,6, 900-905. doi: CIRCULATIONAHA.104.506337 [pii] 10.1161/CIRCULATIONAHA.104.506337
9.
go back to reference Fazekas, F., Niederkorn, K., Schmidt, R., Offenbacher, H., Horner, S. & Bertha, G. (1988). White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors.Stroke, 19,10, 1285-1288.PubMedCrossRef Fazekas, F., Niederkorn, K., Schmidt, R., Offenbacher, H., Horner, S. & Bertha, G. (1988). White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors.Stroke, 19,10, 1285-1288.PubMedCrossRef
10.
go back to reference Ferri, C.P., Prince, M., Brayne, C., Brodaty, H., Fratiglioni, L. & Ganguli, M. (2005). Global prevalence of dementia: a Delphi consensus study.Lancet, 366,9503, 2112-2117. doi: S0140-6736(05)67889-0 [pii] 10.1016/S0140-6736(05)67889-0 Ferri, C.P., Prince, M., Brayne, C., Brodaty, H., Fratiglioni, L. & Ganguli, M. (2005). Global prevalence of dementia: a Delphi consensus study.Lancet, 366,9503, 2112-2117. doi: S0140-6736(05)67889-0 [pii] 10.1016/S0140-6736(05)67889-0
11.
go back to reference Fornage, M., Debette, S., Bis, J.C., Schmidt, H., Ikram, M.A., Dufouil, C. (2011). Genome-wide association studies of cerebral white matter lesion burden: The CHARGE consortium. Annals of Neurology, Epub ahead of print. Fornage, M., Debette, S., Bis, J.C., Schmidt, H., Ikram, M.A., Dufouil, C. (2011). Genome-wide association studies of cerebral white matter lesion burden: The CHARGE consortium. Annals of Neurology, Epub ahead of print.
12.
go back to reference Goos, J. & Flier, W. van der (2011). Microbloedingen bij de ziekte van Alzheimer: de onschuld voorbij?Neuropraxis, 5, 134-137.CrossRef Goos, J. & Flier, W. van der (2011). Microbloedingen bij de ziekte van Alzheimer: de onschuld voorbij?Neuropraxis, 5, 134-137.CrossRef
13.
go back to reference Greenberg, S.M., Vernooij, M.W., Cordonnier, C., Viswanathan, A., Al-Shahi Salman, R. & Warach, S. (2009). Cerebral microbleeds: a guide to detection and interpretation.Lancet Neurology, 8,2, 165-174. doi: S1474-4422(09)70013-4 [pii] 10.1016 S1474-4422(09)70013-4 Greenberg, S.M., Vernooij, M.W., Cordonnier, C., Viswanathan, A., Al-Shahi Salman, R. & Warach, S. (2009). Cerebral microbleeds: a guide to detection and interpretation.Lancet Neurology, 8,2, 165-174. doi: S1474-4422(09)70013-4 [pii] 10.1016 S1474-4422(09)70013-4
14.
go back to reference Groot, J.C. de, Leeuw, F.E. de, Oudkerk, M., Hofman, A., Jolles, J. & Breteler, M.M. (2001). Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study.Neurology, 56,11, 1539-1545.PubMed Groot, J.C. de, Leeuw, F.E. de, Oudkerk, M., Hofman, A., Jolles, J. & Breteler, M.M. (2001). Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study.Neurology, 56,11, 1539-1545.PubMed
15.
go back to reference Groot, J.C.de, Leeuw, F.E. de, Oudkerk, M., Gijn, J. van, Hofman, A. & Jolles, J. (2000). Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study.Annals of Neurology, 47,2, 145-151.PubMedCrossRef Groot, J.C.de, Leeuw, F.E. de, Oudkerk, M., Gijn, J. van, Hofman, A. & Jolles, J. (2000). Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study.Annals of Neurology, 47,2, 145-151.PubMedCrossRef
16.
go back to reference Heijer, T. den, Launer, L.J., Prins, N.D., Dijk, E.J. van, Vermeer, S.E. & Hofman, A. (2005). Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe.Neurology, 64,2, 263-267. doi: 64/2/263 [pii] 10.1212/01.WNL.0000149641.55751.2E Heijer, T. den, Launer, L.J., Prins, N.D., Dijk, E.J. van, Vermeer, S.E. & Hofman, A. (2005). Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe.Neurology, 64,2, 263-267. doi: 64/2/263 [pii] 10.1212/01.WNL.0000149641.55751.2E
17.
go back to reference Heijer, T. den, Lijn, F. van der, Koudstaal, P.J., Hofman, A., Lugt, A. van der & Krestin, G.P. (2010). A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline.Brain, 133(Pt 4), 1163-1172. doi: awq048 [pii] 10.1093/brain/awq048 Heijer, T. den, Lijn, F. van der, Koudstaal, P.J., Hofman, A., Lugt, A. van der & Krestin, G.P. (2010). A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline.Brain, 133(Pt 4), 1163-1172. doi: awq048 [pii] 10.1093/brain/awq048
18.
go back to reference Hofman, A., Breteler, M.M., Duijn, C.M. van, Janssen, H.L., Krestin, G.P. & Kuipers, E.J. (2009). The Rotterdam Study: 2010 objectives and design update. EuropeanJournal of Epidemiology, 24,9, 553-572. doi: 10.1007/s10654-009-9386-z Hofman, A., Breteler, M.M., Duijn, C.M. van, Janssen, H.L., Krestin, G.P. & Kuipers, E.J. (2009). The Rotterdam Study: 2010 objectives and design update. EuropeanJournal of Epidemiology, 24,9, 553-572. doi: 10.1007/s10654-009-9386-z
19.
go back to reference Hofman, A., Breteler, M.M., van Duijn, C.M., Krestin, G.P., Pols, H.A. & Stricker, B.H. (2007). The Rotterdam Study: objectives and design update. EuropeanJournal of Epidemiology, 22,11, 819-829. doi: 10.1007/s10654-007-9199-x Hofman, A., Breteler, M.M., van Duijn, C.M., Krestin, G.P., Pols, H.A. & Stricker, B.H. (2007). The Rotterdam Study: objectives and design update. EuropeanJournal of Epidemiology, 22,11, 819-829. doi: 10.1007/s10654-007-9199-x
20.
go back to reference Hofman, A., Duijn, C.M. van, Franco, O.H., Ikram, M.A., Janssen, H.L. & Klaver, C.C. (2011). The Rotterdam Study: 2012 objectives and design update. EuropeanJournal of Epidemiology, 26,8, 657-686. doi: 10.1007/s10654-011-9610-5 Hofman, A., Duijn, C.M. van, Franco, O.H., Ikram, M.A., Janssen, H.L. & Klaver, C.C. (2011). The Rotterdam Study: 2012 objectives and design update. EuropeanJournal of Epidemiology, 26,8, 657-686. doi: 10.1007/s10654-011-9610-5
21.
go back to reference Hofman, A., Grobbee, D.E., Jong, P.T. de & Ouweland, F.A. van den (1991). Determinants of disease and disability in the elderly: the Rotterdam Elderly Study.European Journal of Epidemiology, 7,4, 403-422.PubMedCrossRef Hofman, A., Grobbee, D.E., Jong, P.T. de & Ouweland, F.A. van den (1991). Determinants of disease and disability in the elderly: the Rotterdam Elderly Study.European Journal of Epidemiology, 7,4, 403-422.PubMedCrossRef
22.
go back to reference Ikram, M.A., Lugt, A. van der, Niessen, W.J., Krestin, G.P., Koudstaal, P.J. & Hofman, A. (2011). The Rotterdam Scan Study: design and update up to 2012. EuropeanJournal of Epidemiology, 26,10, 811-824. doi: 10.1007/s10654-011-9624-z Ikram, M.A., Lugt, A. van der, Niessen, W.J., Krestin, G.P., Koudstaal, P.J. & Hofman, A. (2011). The Rotterdam Scan Study: design and update up to 2012. EuropeanJournal of Epidemiology, 26,10, 811-824. doi: 10.1007/s10654-011-9624-z
23.
go back to reference Ikram, M.A., Oijen, M. van, Jong, F.J. de, Kors, J.A., Koudstaal, P.J. & Hofman, A. (2008). Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease.Stroke, 39,5, 1421-1426. doi: STROKEAHA.107.501106 [pii] 10.1161/ STROKEAHA.107.501106 Ikram, M.A., Oijen, M. van, Jong, F.J. de, Kors, J.A., Koudstaal, P.J. & Hofman, A. (2008). Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease.Stroke, 39,5, 1421-1426. doi: STROKEAHA.107.501106 [pii] 10.1161/ STROKEAHA.107.501106
24.
go back to reference Ikram, M.A., Seshadri, S., Bis, J.C., Fornage, M., DeStefano, A.L. & Aulchenko, Y.S. (2009). Genomewide association studies of stroke.New England Journal of Medicine, 360,17, 1718-1728. doi: NEJMoa0900094 [pii] 10.1056/NEJMoa0900094 Ikram, M.A., Seshadri, S., Bis, J.C., Fornage, M., DeStefano, A.L. & Aulchenko, Y.S. (2009). Genomewide association studies of stroke.New England Journal of Medicine, 360,17, 1718-1728. doi: NEJMoa0900094 [pii] 10.1056/NEJMoa0900094
25.
go back to reference Ikram, M.A., Vernooij, M.W., Hofman, A., Niessen, W J., Lugt, A. van der & Breteler, M.M. (2008). Kidney function is related to cerebral small vessel disease.Stroke, 39,1, 55-61. doi: STROKEAHA.107.493494 [pii] 10.1161/STROKEAHA.107.493494 Ikram, M.A., Vernooij, M.W., Hofman, A., Niessen, W J., Lugt, A. van der & Breteler, M.M. (2008). Kidney function is related to cerebral small vessel disease.Stroke, 39,1, 55-61. doi: STROKEAHA.107.493494 [pii] 10.1161/STROKEAHA.107.493494
26.
go back to reference Ikram, M.A., Vrooman, H.A., Vernooij, M.W., Heijer, T. den, Hofman, A. & Niessen, W.J. (2010). Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiology of Aging, 31,3, 378-386. doi: S0197-4580(08)00133-4 [pii] 10.1016/j.neurobiolaging.2008.04.008 Ikram, M.A., Vrooman, H.A., Vernooij, M.W., Heijer, T. den, Hofman, A. & Niessen, W.J. (2010). Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiology of Aging, 31,3, 378-386. doi: S0197-4580(08)00133-4 [pii] 10.1016/j.neurobiolaging.2008.04.008
27.
go back to reference Ikram, M.A., Vrooman, H.A., Vernooij, M.W., Lijn, F. van der, Hofman, A. & Lugt, A. van der (2008). Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiology of Aging, 29,6, 882-890. doi: S0197-4580(06)00467-2 [pii] 10.1016/j.neurobiolaging.2006.12.012 Ikram, M.A., Vrooman, H.A., Vernooij, M.W., Lijn, F. van der, Hofman, A. & Lugt, A. van der (2008). Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiology of Aging, 29,6, 882-890. doi: S0197-4580(06)00467-2 [pii] 10.1016/j.neurobiolaging.2006.12.012
28.
go back to reference Ikram, M.K., Jong, F.J. de, Dijk, E.J. van, Prins, N.D., Hofman, A. & Breteler, M.M. (2006). Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study.Brain, 129(Pt 1), 182-188. doi: awh688 [pii] 10.1093/brain/awh688 Ikram, M.K., Jong, F.J. de, Dijk, E.J. van, Prins, N.D., Hofman, A. & Breteler, M.M. (2006). Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study.Brain, 129(Pt 1), 182-188. doi: awh688 [pii] 10.1093/brain/awh688
29.
go back to reference Kandel, E.R., Schwartz, J.H. & Jessell, T.M. (2000).Principles of Neural Science (4th ed.): McGraw-Hill. Kandel, E.R., Schwartz, J.H. & Jessell, T.M. (2000).Principles of Neural Science (4th ed.): McGraw-Hill.
30.
go back to reference Kapeller, P., Schmidt, R. & Fazekas, F. (2004). Qualitative MRI: evidence of usual aging in the brain.Topics in Magnetic Resonance Imaging, 15,6, 343-347. doi: 00002142-200412000-00002 [pii] Kapeller, P., Schmidt, R. & Fazekas, F. (2004). Qualitative MRI: evidence of usual aging in the brain.Topics in Magnetic Resonance Imaging, 15,6, 343-347. doi: 00002142-200412000-00002 [pii]
31.
go back to reference Launer, L.J. & Hofman, A. (2000). Frequency and impact of neurologic diseases in the elderly of Europe: A collaborative study of population-based cohorts.Neurology, 54,11, Suppl 5, S1-8. Launer, L.J. & Hofman, A. (2000). Frequency and impact of neurologic diseases in the elderly of Europe: A collaborative study of population-based cohorts.Neurology, 54,11, Suppl 5, S1-8.
32.
go back to reference Launer, L.J. (2003). Epidemiology of white-matter lesions.International Psychogeriatrics, 15, Suppl 1, 99-103. doi: S1041610203009037 [pii] 10.1017/S1041610203009037 Launer, L.J. (2003). Epidemiology of white-matter lesions.International Psychogeriatrics, 15, Suppl 1, 99-103. doi: S1041610203009037 [pii] 10.1017/S1041610203009037
33.
go back to reference Launer, L.J. (2004). Epidemiology of white matter lesions.Topics in Magnetic Resonance Imaging, 15,6, 365-367. doi: 00002142-200412000-00005 [pii] Launer, L.J. (2004). Epidemiology of white matter lesions.Topics in Magnetic Resonance Imaging, 15,6, 365-367. doi: 00002142-200412000-00005 [pii]
34.
go back to reference Launer, L.J., Oudkerk, M., Nilsson, L.G., Alperovitch, A., Berger, K. & Breteler, M.M. (2000). CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives.Neuroepidemiology, 19,3, 113-120. doi: 26246 [pii] Launer, L.J., Oudkerk, M., Nilsson, L.G., Alperovitch, A., Berger, K. & Breteler, M.M. (2000). CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives.Neuroepidemiology, 19,3, 113-120. doi: 26246 [pii]
35.
go back to reference Leeuw, F.E. de, Groot, J.C. de, Oudkerk, M., Witteman, J.C., Hofman, A., Gijn, J. van (1999). A follow-up study of blood pressure and cerebral white matter lesions.Annals of Neurology, 46,6, 827-833.PubMedCrossRef Leeuw, F.E. de, Groot, J.C. de, Oudkerk, M., Witteman, J.C., Hofman, A., Gijn, J. van (1999). A follow-up study of blood pressure and cerebral white matter lesions.Annals of Neurology, 46,6, 827-833.PubMedCrossRef
36.
go back to reference Leeuw, F.E. de, Groot, J.C. de, Oudkerk, M., Witteman, J.C., Hofman, A., Gijn, J. van (2002). Hypertension and cerebral white matter lesions in a prospective cohort study.Brain, 125(Pt 4), 765-772.PubMedCrossRef Leeuw, F.E. de, Groot, J.C. de, Oudkerk, M., Witteman, J.C., Hofman, A., Gijn, J. van (2002). Hypertension and cerebral white matter lesions in a prospective cohort study.Brain, 125(Pt 4), 765-772.PubMedCrossRef
37.
go back to reference Leeuw, F.E.de, Groot, J.C. de, Achten, E., Oudkerk, M., Ramos, L.M. & Heijboer, R. (2001). Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study.Journal of Neurology, Neurosurgery, and Psychiatry, 70,1, 9-14.PubMedCrossRef Leeuw, F.E.de, Groot, J.C. de, Achten, E., Oudkerk, M., Ramos, L.M. & Heijboer, R. (2001). Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study.Journal of Neurology, Neurosurgery, and Psychiatry, 70,1, 9-14.PubMedCrossRef
38.
go back to reference Lijn, F. van der, Heijer, T. den, Breteler, M.M. & Niessen, W.J. (2008). Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts.Neuroimage, 43,4, 708-720. doi: S1053-8119(08)00886-0 [pii] 10.1016/j.neuroimage.2008.07.058 Lijn, F. van der, Heijer, T. den, Breteler, M.M. & Niessen, W.J. (2008). Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts.Neuroimage, 43,4, 708-720. doi: S1053-8119(08)00886-0 [pii] 10.1016/j.neuroimage.2008.07.058
39.
go back to reference Massaro, J.M., D’Agostino, R.B., Sr., Sullivan, L.M., Beiser, A., DeCarli, C. & Au, R. (2004). Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive function.Statistics in Medicine, 23,2, 351-367. doi: 10.1002/sim.1743 Massaro, J.M., D’Agostino, R.B., Sr., Sullivan, L.M., Beiser, A., DeCarli, C. & Au, R. (2004). Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive function.Statistics in Medicine, 23,2, 351-367. doi: 10.1002/sim.1743
40.
go back to reference Mesker, D.J., Poels, M M., Ikram, M A., Vernooij, M.W., Hofman, A. & Vrooman, H. A. (2011). Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study.Archives of Neurology, 68,5, 656-659. doi: 68/5/656 [pii] 10.1001/archneurol.2011.93 Mesker, D.J., Poels, M M., Ikram, M A., Vernooij, M.W., Hofman, A. & Vrooman, H. A. (2011). Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study.Archives of Neurology, 68,5, 656-659. doi: 68/5/656 [pii] 10.1001/archneurol.2011.93
41.
go back to reference Poels, M.M., Ikram, M.A., Lugt, A. van der, Hofman, A., Krestin, G.P., Breteler, M.M. (2011). Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study.Stroke, 42,3, 656-661. doi: STROKEAHA.110.607184 [pii] 10.1161/STROKEAHA.110.607184 Poels, M.M., Ikram, M.A., Lugt, A. van der, Hofman, A., Krestin, G.P., Breteler, M.M. (2011). Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study.Stroke, 42,3, 656-661. doi: STROKEAHA.110.607184 [pii] 10.1161/STROKEAHA.110.607184
42.
go back to reference Poels, M.M., Ikram, M.A., Vernooij, M.W., Krestin, G.P., Hofman, A. & Niessen, W.J. (2008). Total cerebral blood flow in relation to cognitive function: the Rotterdam Scan Study.Journal of Cerebral Blood Flow & Metabolism, 28,10, 1652-1655. doi: jcbfm200862 [pii] 10.1038/jcbfm.2008.62 Poels, M.M., Ikram, M.A., Vernooij, M.W., Krestin, G.P., Hofman, A. & Niessen, W.J. (2008). Total cerebral blood flow in relation to cognitive function: the Rotterdam Scan Study.Journal of Cerebral Blood Flow & Metabolism, 28,10, 1652-1655. doi: jcbfm200862 [pii] 10.1038/jcbfm.2008.62
43.
go back to reference Poels, M.M., Vernooij, M. W., Ikram, M.A., Hofman, A., Krestin, G.P. & Lugt, A. van der (2010). Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study.Stroke, 41,10 Suppl, S103-106. doi: 41/10_suppl_1/S103 [pii] 10.1161/STROKEAHA.110.595181 Poels, M.M., Vernooij, M. W., Ikram, M.A., Hofman, A., Krestin, G.P. & Lugt, A. van der (2010). Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study.Stroke, 41,10 Suppl, S103-106. doi: 41/10_suppl_1/S103 [pii] 10.1161/STROKEAHA.110.595181
44.
go back to reference Poels, M.M.F., Ikram, M.A., & Vernooij, M.W. Improved MRI detection of cerebral microbleeds more accurately identifies persons with vasculopathy.American Journal of Neuroradiology. Poels, M.M.F., Ikram, M.A., & Vernooij, M.W. Improved MRI detection of cerebral microbleeds more accurately identifies persons with vasculopathy.American Journal of Neuroradiology.
45.
go back to reference Poels, M.M.F., Ikram, M.A., Lugt, A. van der, Hofman, A., Niessen, W.J., Krestin, G.P. Cerebral microbleeds are associated with worse cognitive function.Neurology. Poels, M.M.F., Ikram, M.A., Lugt, A. van der, Hofman, A., Niessen, W.J., Krestin, G.P. Cerebral microbleeds are associated with worse cognitive function.Neurology.
46.
go back to reference Prins, N.D., Dijk, E.J. van, Heijer, T. den, Vermeer, S.E., Jolles, J. & Koudstaal, P.J. (2005). Cerebral small-vessel disease and decline in information processing speed, executive function and memory.Brain, 128,Pt 9, 2034-2041. doi: awh553 [pii] 10.1093/brain/awh553 Prins, N.D., Dijk, E.J. van, Heijer, T. den, Vermeer, S.E., Jolles, J. & Koudstaal, P.J. (2005). Cerebral small-vessel disease and decline in information processing speed, executive function and memory.Brain, 128,Pt 9, 2034-2041. doi: awh553 [pii] 10.1093/brain/awh553
47.
go back to reference Schmidt, R., Fazekas, F., Kapeller, P., Schmidt, H. & Hartung, H.P. (1999). MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study.Neurology, 53,1, 132-139.PubMed Schmidt, R., Fazekas, F., Kapeller, P., Schmidt, H. & Hartung, H.P. (1999). MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study.Neurology, 53,1, 132-139.PubMed
48.
go back to reference Schmidt, R., Fazekas, F., Offenbacher, H., Lytwyn, H., Blematl, B. & Niederkorn, K. (1991). Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals.Archives of Neurology, 48,4, 417-420.PubMedCrossRef Schmidt, R., Fazekas, F., Offenbacher, H., Lytwyn, H., Blematl, B. & Niederkorn, K. (1991). Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals.Archives of Neurology, 48,4, 417-420.PubMedCrossRef
49.
go back to reference Verhaaren, B.F., Boer, R. de, Vernooij, M.W., Rivadeneira, F., Uitterlinden, A.G. & Hofman, A. (2011). Replication study of chr17q25 with cerebral white matter lesion volume.Stroke, 42,11, 3297-3299. doi: STROKEAHA.111.623090 [pii] 10.1161/STROKEAHA.111.623090 Verhaaren, B.F., Boer, R. de, Vernooij, M.W., Rivadeneira, F., Uitterlinden, A.G. & Hofman, A. (2011). Replication study of chr17q25 with cerebral white matter lesion volume.Stroke, 42,11, 3297-3299. doi: STROKEAHA.111.623090 [pii] 10.1161/STROKEAHA.111.623090
50.
go back to reference Vermeer, S.E., Dijk, E.J. van, Koudstaal, P.J., Oudkerk, M., Hofman, A. & Clarke, R. (2002). Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study.Annals of Neurology, 51, 3, 285-289. doi: 10.1002/ana.10111 [pii] Vermeer, S.E., Dijk, E.J. van, Koudstaal, P.J., Oudkerk, M., Hofman, A. & Clarke, R. (2002). Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study.Annals of Neurology, 51, 3, 285-289. doi: 10.1002/ana.10111 [pii]
51.
go back to reference Vermeer, S.E., Heijer, T. den, Koudstaal, P.J., Oudkerk, M., Hofman, A., Breteler, M.M. (2003). Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.Stroke, 34, 2, 392-396.PubMedCrossRef Vermeer, S.E., Heijer, T. den, Koudstaal, P.J., Oudkerk, M., Hofman, A., Breteler, M.M. (2003). Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.Stroke, 34, 2, 392-396.PubMedCrossRef
52.
go back to reference Vermeer, S.E., Hollander, M., Dijk, E.J. van, Hofman, A., Koudstaal, P.J. & Breteler, M.M. (2003). Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study.Stroke, 34,5, 1126-1129. doi: 10.1161/01.STR.0000068408.82115.D2 01.STR.0000068408.82115.D2 Vermeer, S.E., Hollander, M., Dijk, E.J. van, Hofman, A., Koudstaal, P.J. & Breteler, M.M. (2003). Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study.Stroke, 34,5, 1126-1129. doi: 10.1161/01.STR.0000068408.82115.D2 01.STR.0000068408.82115.D2
53.
go back to reference Vermeer, S.E., Koudstaal, P.J., Oudkerk, M., Hofman, A. & Breteler, M. M. (2002). Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.Stroke, 33 ,1, 21-25.PubMedCrossRef Vermeer, S.E., Koudstaal, P.J., Oudkerk, M., Hofman, A. & Breteler, M. M. (2002). Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.Stroke, 33 ,1, 21-25.PubMedCrossRef
54.
go back to reference Vermeer, S.E., Prins, N.D., Heijer, T. den, Hofman, A., Koudstaal, P.J. & Breteler, M.M. (2003). Silent brain infarcts and the risk of dementia and cognitive decline.New England Journal of Medicine, 348,13, 1215-1222. doi: 10.1056/NEJMoa022066 348/13/1215[pii] Vermeer, S.E., Prins, N.D., Heijer, T. den, Hofman, A., Koudstaal, P.J. & Breteler, M.M. (2003). Silent brain infarcts and the risk of dementia and cognitive decline.New England Journal of Medicine, 348,13, 1215-1222. doi: 10.1056/NEJMoa022066 348/13/1215[pii]
55.
go back to reference Vernooij, M. W., de Groot, M., van der Lugt, A., Ikram, M. A., Krestin, G. P., Hofman, A. (2008). White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging.Neuroimage, 43(3), 470-477. doi: S1053-8119(08)00887-2 [pii] 10.1016/j.neuroimage.2008.07.052 Vernooij, M. W., de Groot, M., van der Lugt, A., Ikram, M. A., Krestin, G. P., Hofman, A. (2008). White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging.Neuroimage, 43(3), 470-477. doi: S1053-8119(08)00887-2 [pii] 10.1016/j.neuroimage.2008.07.052
56.
go back to reference Vernooij, M.W., Haag, M.D., Lugt, A., van der Hofman, A., Krestin, G.P. & Stricker, B. H. (2009). Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study.Archibves of Neurology, 66,6, 714-720. doi: 2009.42 [pii] 10.1001/archneurol.2009.42 Vernooij, M.W., Haag, M.D., Lugt, A., van der Hofman, A., Krestin, G.P. & Stricker, B. H. (2009). Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study.Archibves of Neurology, 66,6, 714-720. doi: 2009.42 [pii] 10.1001/archneurol.2009.42
57.
go back to reference Vernooij, M.W., Ikram, M.A., Tanghe, H.L., Vincent, A.J., Hofman, A. & Krestin, G.P. (2007). Incidental findings on brain MRI in the general population.New England Journal of Medicine, 357(18), 1821-1828. doi: 357/18/1821 [pii] 10.1056/NEJMoao70972 Vernooij, M.W., Ikram, M.A., Tanghe, H.L., Vincent, A.J., Hofman, A. & Krestin, G.P. (2007). Incidental findings on brain MRI in the general population.New England Journal of Medicine, 357(18), 1821-1828. doi: 357/18/1821 [pii] 10.1056/NEJMoao70972
58.
go back to reference Vernooij, M.W., Ikram, M.A., Vrooman, H.A., Wielopolski, P.A., Krestin, G.P. & Hofman, A. (2009). White matter microstructural integrity and cognitive function in a general elderly population.Archives of General Psychiatry, 66,5, 545-553. doi: 66/5/545 [pii] 10.1001/archgenpsychiatry.2009.5 Vernooij, M.W., Ikram, M.A., Vrooman, H.A., Wielopolski, P.A., Krestin, G.P. & Hofman, A. (2009). White matter microstructural integrity and cognitive function in a general elderly population.Archives of General Psychiatry, 66,5, 545-553. doi: 66/5/545 [pii] 10.1001/archgenpsychiatry.2009.5
59.
go back to reference Vernooij, M.W., Ikram, M.A., Wielopolski, P.A., Krestin, G.P., Breteler, M.M. & van der Lugt, A. (2008). Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection.Radiology, 248,1, 272-277. doi: 2481071158 [pii] 10.1148/radiol.2481071158 Vernooij, M.W., Ikram, M.A., Wielopolski, P.A., Krestin, G.P., Breteler, M.M. & van der Lugt, A. (2008). Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection.Radiology, 248,1, 272-277. doi: 2481071158 [pii] 10.1148/radiol.2481071158
60.
go back to reference Vernooij, M.W., Lugt, A. van der, Ikram, M.A., Wielopolski, P.A., Niessen, W.J. & Hofman, A. (2008). Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study.Neurology, 70,14, 1208-1214. doi: 70/14/1208 [pii] 10.1212/01.wnl.000307750.41970.d9 Vernooij, M.W., Lugt, A. van der, Ikram, M.A., Wielopolski, P.A., Niessen, W.J. & Hofman, A. (2008). Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study.Neurology, 70,14, 1208-1214. doi: 70/14/1208 [pii] 10.1212/01.wnl.000307750.41970.d9
61.
go back to reference Vernooij, M.W., Lugt, A. van der, Ikram, M.A., Wielopolski, P.A., Vrooman, H.A., Hofman, A. (2008). Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study.Journal of Cerebral Blood Flow & Metabolism, 28,2, 412-419. doi: 9600526 [pii] 10.1038/sj.jcbfm.9600526 Vernooij, M.W., Lugt, A. van der, Ikram, M.A., Wielopolski, P.A., Vrooman, H.A., Hofman, A. (2008). Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study.Journal of Cerebral Blood Flow & Metabolism, 28,2, 412-419. doi: 9600526 [pii] 10.1038/sj.jcbfm.9600526
63.
go back to reference Vrooman, H.A., Cocosco, C.A., Lijn, F. van der, Stokking, R., Ikram, M.A., Vernooij, M.W. (2007). Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification.Neuroimage, 37,1, 71-81. doi: S1053-8119(07)00418-1 [pii] 10.1016/j.neuroimage.2007.05.018 Vrooman, H.A., Cocosco, C.A., Lijn, F. van der, Stokking, R., Ikram, M.A., Vernooij, M.W. (2007). Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification.Neuroimage, 37,1, 71-81. doi: S1053-8119(07)00418-1 [pii] 10.1016/j.neuroimage.2007.05.018
Metagegevens
Titel
DeRotterdam Scan Study: een grootschalig MRI-onderzoek naar hersenziekten
Auteurs
Drs. Mariëlle Poels
Drs. Benjamin Verhaaren
Drs. Yoo Young Hoogendam
Dr. Arfan Ikram
Drs. Daniel Bos
Dr. Meike Vernooij
Publicatiedatum
01-02-2012
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 1/2012
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-012-0004-6

Andere artikelen Uitgave 1/2012

Neuropraxis 1/2012 Naar de uitgave

OriginalPaper

Woorden vooraf

OriginalPaper

Signalement