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01-04-2007 | original article

Clinical characteristics, cardiac events and coronary angiographic findings in the prospective PREVEND cohort: an observational study

Auteurs: C. A. Geluk, R. A. Tio, J. G. P. Tijssen, R. B. van Dijk, W. A. Dijk, H. L. Hillege, P. E. de Jong, W. H. van Gilst, F. Zijlstra

Gepubliceerd in: Netherlands Heart Journal | Uitgave 4/2007

Abstract

Background: The use of invasive procedures has mostly been studied in retrospective (multi)- national registries. Limited evidence exists on the association between microalbuminuria and coronary artery disease (CAD).

Methods: The incidence of major adverse cardiac events (MACE) and invasive cardiac procedures was registered between 1997 and 2003 in 8139 subjects, without prior documented CAD, in the PREVEND cohort study (the Netherlands), in which the focus is on microalbuminuria and cardiovascular risk. Qualitative coronary angiographic analysis was performed.

Results: During 5.5 years of follow-up, a first MACE occurred in 271 (3.3%) and a first coronary angiography (CAG) was performed in 264 (3.2%) subjects. Of these, 216 CAGs were available for qualitative angiographic analysis. Indications for CAG were stable angina in 129, acute coronary syndrome (ACS) in 55 and ST-elevation myocardial infarction (STEMI) in 32 subjects. Obstructive coronary artery disease was present in 61, 53 and 30 subjects, respectively. A revascularisation was performed in 50 (39%), 50 (91%) and 25 (78%) subjects, respectively. Microalbuminuria was associated with a first MACE, after adjustment for established risk factors. Microalbuminuria was present at baseline in 9% of subjects with normal coronary arteries, in 21% of subjects with one- and two-vessel CAD and in 39% of subjects with threevessel or left main CAD at CAG during follow-up (Ptrend=0.005).

Conclusion: This large cohort study shows that two-thirds of diagnostic CAGs for stable angina were not followed by a revascularisation, in contrast to CAGs for STEMI or ACS. Furthermore, this study shows that microalbuminuria is associated with CAD. (Neth Heart J 2007;15:133-41.)

vorige artikel Clinical implementation of guidelines for cardioverter defibrillator implantation: lost in translation?

volgende artikel Exercise prescription for patients with a Fontan circulation: current evidence and future directions

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Titel: Clinical characteristics, cardiac events and coronary angiographic findings in the prospective PREVEND cohort: an observational study
Auteurs: C. A. Geluk
R. A. Tio
J. G. P. Tijssen
R. B. van Dijk
W. A. Dijk
H. L. Hillege
P. E. de Jong
W. H. van Gilst
F. Zijlstra
Publicatiedatum: 01-04-2007
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Netherlands Heart Journal / Uitgave 4/2007
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI: https://doi.org/10.1007/BF03085969

Bohn Stafleu van Loghum

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